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Biomimetic tubular material

A bionic tube, tubular technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of not being able to be used as a permanent repair material alone, insufficient long-term mechanical properties, increased postoperative recurrence rate, etc., to reduce the possibility of stenosis. Sex, avoid tissue swelling, increase the effect of biocompatibility

Inactive Publication Date: 2018-09-11
BEIJING PAISHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been proven to be the most popular implant in the field of surgical implants today, there are still some problems in the application of polypropylene mesh: first, when it is used for the repair of full-thickness abdominal wall defects, the bioprosthetic membrane must be combined with Visceral tissue isolation, if it is in direct contact with internal organs, it can cause severe abdominal adhesions, digestive tract obstruction, and may even erode the intestinal wall, causing intestinal fistula, increasing the pain of the patient and even requiring a second operation to remove the bioprosthetic membrane
[0006] Existing absorbable bioremediation membranes such as polyglycolic acid and polylactic glycolic acid cannot be used as permanent repair materials alone due to their limited mechanical properties. They can only be used as temporary repairs to help patients survive the dangerous period of disease. Non-absorbable bioremediation membrane for permanent repair
The emerging collagen-based biorepair membranes, such as extracellular matrix, are degradable and have good resistance to infection. Compared with other commonly used synthetic materials in clinical practice, they have great advantages, but they have long-term mechanical properties. Insufficient risk, which may lead to surgical failure and increased postoperative recurrence rate

Method used

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  • Biomimetic tubular material

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A new type of bionic tubular material composed of collagen and polypropylene. The base tube membrane is polypropylene mesh, and the contact tube membrane is collagen. After the two are compounded, the collagen is cross-linked again. Its preparation method is:

[0035] 1): The mesh braid made of non-degradable polypropylene fiber is cut and sewn into a tubular shape, and the two tubular braids are put together, then cleaned, sterilized, and soaked in ionic liquid, called It is a double-layer network management;

[0036] 2): Dissolving atelocollagen in water to obtain a solution for use;

[0037] 3): Inject the solution obtained in step 2) into a cylindrical mold, the thickness of which is 3mm larger than the diameter of the double-layer network pipe; put the double-layer network pipe in step 1) on the stainless steel rod, the diameter of the stainless steel rod is equal to the inner diameter of the inner network pipe , and then placed in the solution in the mold, the d...

Embodiment 2

[0043]A new type of bionic tubular material composed of collagen and polypropylene. The base tube membrane is polypropylene mesh, and the contact tube membrane is collagen and sodium hyaluronate. After the two are compounded, the collagen is cross-linked again. Its preparation method is:

[0044] 1): The mesh braid made of non-degradable polypropylene fiber is cut and sewn into a tubular shape, and the two tubular braids are put together, then cleaned, sterilized, and soaked in ionic liquid, called It is a double-layer network management;

[0045] 2): Dissolving atelocollagen and sodium hyaluronate in water respectively to obtain a solution for use;

[0046] 3): Inject the solution obtained in step 2) into a cylindrical mold, the thickness of which is 3mm larger than the diameter of the double-layer network pipe; put the double-layer network pipe in step 1) on the glass rod, and the diameter of the glass rod is equal to the inner diameter of the inner network pipe , and then...

Embodiment 3

[0052] A new type of bionic tubular material composed of collagen and polypropylene. The base tube membrane is polypropylene mesh, the contact tube membrane is collagen, and paclitaxel is added. After the two are compounded, the collagen is cross-linked again. Its preparation method is:

[0053] 1): The mesh braid made of non-degradable polypropylene fiber is cut and sewn into a tubular shape, and the two tubular braids are put together, then cleaned, sterilized, and soaked in ionic liquid, called It is a double-layer network management;

[0054] 2): Dissolve atelocollagen in water and set aside;

[0055] 3): Inject the solution obtained in step 2) into a cylindrical mold, the thickness of which is 3mm larger than the diameter of the double-layer network pipe; put the double-layer network pipe in step 1) on the stainless steel rod, the diameter of the stainless steel rod is equal to the inner diameter of the inner network pipe , and then placed in the solution in the mold, t...

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Abstract

The invention relates to a biomimetic tubular material. The material is composed of a substrate tube membrane and contact tube membranes, wherein the substrate tube membrane is placed between the twocontact tube membranes; the material is characterized in that the substrate tube membrane is prepared from a nondegradable high-molecular polymer, the contact tube membranes are prepared from a biodegradable material, the three tube membranes are compounded closely, and the surface of an anti-adhesion biomimetic repairing membrane is flat; the nondegradable high-molecular polymer is one or more ofnondegradable polyester, polyethylene, polypropylene and teflon, and a degradable high-molecular polymer is one or more of degradable hyaluronic acid, collagen, chitosan, polylactic acid, polyglycollide, polydioxanone and polyhydroxyalkanoate.

Description

technical field [0001] The invention belongs to the technical field of medical materials and is mainly used for the repair of tubular tissues of human body. Background technique [0002] Tubular materials are commonly used in surgical operations to replace diseased or damaged human tubular tissues, such as blood vessels, intestines, etc. Although it is safe and compatible to transplant autologous materials for repair, it will cause damage to human tissue after all, and some tubular tissues cannot be transplanted. Therefore, artificial bionic tubular materials have become a research hotspot. [0003] The biocompatible tubular material used in the surgery is the most critical. At present, there are two main types, one is a tube made of a high-strength but non-degradable polymer film, and the other is a tube made of a biodegradable polymer film with better biocompatibility. [0004] Although the polyester bioprosthetic membrane has good flexibility, its tensile strength is w...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/50A61L27/54A61L27/56A61L27/24A61L27/16
CPCA61L27/16A61L27/24A61L27/50A61L27/54A61L27/56A61L2300/416A61L2300/602A61L2430/22C08L23/12
Inventor 张自强杜伟刘明东杜虎李欢符斌
Owner BEIJING PAISHENG BIOTECH CO LTD