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New application of cistanche polysaccharides and pharmaceutical composition with same

A technology of cistanche polysaccharide and composition, applied in the field of medicine

Inactive Publication Date: 2018-09-14
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Tu Pengfei's research group used the HPLC-UV method to study the metabolism of echinacoside in vivo, and found that its pharmacokinetics conformed to the characteristics of a one-compartment model after intragastric administration (100mg / kg), and the peak time was 15.0min, but The peak concentration is only (612.2±320.4) ng / mL, and the absolute bioavailability is only 0.83% [27]

Method used

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  • New application of cistanche polysaccharides and pharmaceutical composition with same
  • New application of cistanche polysaccharides and pharmaceutical composition with same
  • New application of cistanche polysaccharides and pharmaceutical composition with same

Examples

Experimental program
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Effect test

preparation example 1

[0233] Preparation Example 1: Preparation of Crude Cistanche Cistanche Cistanche Phenylethanol Glycoside (PHE)

[0234] Take 3kg slices of Cistanche deserticola medicinal material, dry and pulverize into coarse powder, and use 85% ethanol (volume percentage concentration, the same below) successively, and the ratio of solid to liquid (unit is kg:L, the same below) is 1:12, 1:12 respectively. 10. Extract twice at 60°C, 2 hours each time, and combine the extracts. The dregs are used in Preparation Example 2 below.

preparation example 2

[0235] After the extract was concentrated under reduced pressure, it was separated by HPD300 macroporous adsorption resin, and eluted with water, 10% ethanol, and 50% ethanol in sequence. The elution flow rate was 1.5 column volumes / hour, and each gradient eluted 4 column volumes.

[0236] The fractions eluted with 50% ethanol were collected, concentrated under reduced pressure and then freeze-dried to obtain 50 g of crude extract of phenylethanol glycosides from Cistanche deserticola (abbreviated as PHE).

[0237] Preparation example 2: preparation of Cistanche total sugar (ZT)

[0238] After the dregs of Preparation Example 1 were evaporated to dry ethanol, they were extracted with boiling water at 100°C, and the ratio of solid to liquid was 1:12 and 1:10 respectively, and the extracts were extracted twice for 2 hours each time, and the extracts were combined.

[0239] After the extract was concentrated under reduced pressure, 95% ethanol was added under constant stirring ...

preparation example 3

[0240] Preparation Example 3: Preparation of Cistanche High Molecular Weight Polysaccharide Extract (HM)

[0241] Get the cistanche total sugar (ZT) sample 245g that preparation example 2 makes, be made into 2% aqueous solution, use molecular weight cut-off to be 100kDa hollow fiber ultrafiltration membrane ultrafiltration, can not pass through the part of 100k hollow fiber ultrafiltration membrane, concentrate freeze-drying Finally, 73 g of high molecular weight segment polysaccharide extract (molecular weight greater than 100,000, referred to as HM) was obtained.

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Abstract

The invention belongs to the field of medicines, and relates to a new application of cistanche polysaccharides and a pharmaceutical composition with the same, in particular to application of cistanchepolysaccharides for preparation of a medicament for promoting in vivo absorption of phenylethanoid glycosides. The invention also relates to a pharmaceutical composition containing cistanche polysaccharides as an active ingredient, a phenylethanoid glycoside compound and / or a plant extract containing a phenylethanoid glycoside compound. Cistanche polysaccharides can effectively promote the in vivo absorption of phenylethanoid glycosides. The pharmaceutical composition disclosed by the invention has an estrogen-like action and is effective for treating and / or preventing osteoporosis.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new application of cistanche polysaccharide and a pharmaceutical composition containing the cistanche polysaccharide. Background technique [0002] Cistanche deserticola (Cistanche deserticola) is the dry fleshy stem with scales of Cistanche deserticola (Cistanche deserticola Y.C.Ma) or C. tubulosa (Schrenk) Wight. It is mainly produced in arid and semi-arid regions of China , Such as: Inner Mongolia, Xinjiang, Gansu, Ningxia, Qinghai and other places, it is known as "desert ginseng". There are 8 species and 1 variety of Cistanche in my country, namely C.deserticola Y.C.Ma(Cd), C.tubulosa(Schrenk)Wight(Ct), C.salsa(C.A.Mey)G.Beck (Csa), C.sinensis G.Beck(Csi), C.lanzhouensis Z.Y.Zhang, C.ambigua(Bge.)G.Beck, C.fissa(C.A.Mey)G. Beck, C. ningxiaensis D.Z.Maet A.Duan and C.salsa var.albiflora P.F.Tu et Z.C.Lou [1,2] . [0003] Cistanche deserticola is sweet, salty and warm in nature and fl...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K31/716A61K31/7032A61K36/64A61P19/10A61P5/30
CPCA61K31/715A61K31/7032A61K31/716A61K36/64A61P5/30A61P19/10A61K2300/00
Inventor 高秀梅付志飞刘二伟赵鑫毛浩萍王小莹
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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