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Application of traditional Chinese medicine composition in preparing medicine for treating cerebral stroke

A composition and technology for ischemic stroke, applied in the field of pharmacology, can solve the problems of ischemia-reperfusion injury, cell apoptosis, limited application, etc., and achieve the effects of improving microcirculation, expanding peripheral blood vessels, and reducing blood viscosity

Inactive Publication Date: 2018-09-14
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of rt-PA is considered to be a breakthrough in the drug treatment of ischemic stroke. In the guidelines for the prevention and treatment of cardiovascular and cerebrovascular diseases in my country, intravenous injection of rt-PA at 0.9 mg / kg is recommended for the acute phase of ischemic stroke. However, the time window for rt-PA thrombolysis is only 3-5 hours, and the intravenous administration method also brings adverse reactions to patients such as respiratory and cardiac arrest [6], and, although rt-PA The use of thrombolytic drugs such as thrombolytic drugs within the time window of thrombolysis can effectively improve the condition, but with the re-patency of the occluded blood vessels, edema, aggravated inflammatory reactions, neuronal metabolic disorders and Pathological injury such as apoptosis, that is, ischemia-reperfusion injury
Therefore, in clinical thrombolytic therapy, these disadvantages further limit the application of thrombolytic drugs represented by rt-PA

Method used

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  • Application of traditional Chinese medicine composition in preparing medicine for treating cerebral stroke
  • Application of traditional Chinese medicine composition in preparing medicine for treating cerebral stroke
  • Application of traditional Chinese medicine composition in preparing medicine for treating cerebral stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation method of embodiment 1 Chinese medicine composition

[0040] Weigh an appropriate amount of Rhizoma Chuanxiong and Pueraria lobata root, mix according to the weight ratio of 1:1, add 10 times the volume of water or (and) ethanol to reflux for extraction for 1 hour, filter, take the filtrate for later use, add 3-20 times the volume of water or (and) ethanol to reflux for extraction , filtered, combined two filtrates, concentrated to make a clear paste (containing puerarin 0.83mg / g). The clear ointment is taken and added with a certain proportion of sucrose powder, dextrin and ethanol in an appropriate amount to make a preparation form suitable for oral administration.

Embodiment 2

[0041] Example 2 The medicinal composition of Chuanxiong and Pueraria lobata can obviously restore the neurological damage caused by ischemic stroke

[0042] experimental method:

[0043] Experimental grouping: 50 healthy SD rats, male, weighing 240-280g, were randomly divided into normal control group, ischemic stroke model group, normal saline group, positive drug group and drug treatment group. Normal control group: the rats were not given any treatment, only given normal saline according to body weight. Ischemic stroke group: After making the right middle cerebral artery occlusion model (Middle Cerebral Artery Occlusion, MCAO), the rats were reperfused for 2 hours and sacrificed. Normal saline group: After preparing the rat right middle cerebral artery occlusion model (Middle Cerebral Artery Occlusion, MCAO), reperfusion for 2 hours, and then giving normal saline every day according to body weight for 14 consecutive days, positive drug group: preparing rats in the right b...

Embodiment 3

[0048] Example 3 Chuanxiong and Pueraria lobata medicinal compositions can improve dyslipidemia caused by ischemic stroke

[0049] The right middle cerebral artery embolism model of rats was adopted, and nimodipine was used as a positive control drug, and the blood lipid level of rats after oral administration of Pueraria lobata and Chuanxiong medicinal compositions was investigated. The contents of serum triglyceride (TG) and total cholesterol (T-CHO) were detected with corresponding kits, and the specific operations were performed according to the instructions. The kit information is shown in Table b. see results image 3 , Figure 4 , table c, table d.

[0050] Form b Information sheet for the kit

[0051]

[0052] Table c Triglyceride (TG) concentration

[0053]

[0054] Table d Total Cholesterol (TCHO) Concentration

[0055]

[0056] The results showed that after ischemic stroke in rats, the levels of total cholesterol and triglycerides were significantly in...

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Abstract

The invention relates to application of a traditional Chinese medicine composition in preparing medicine for treating cerebral stroke, and particularly discloses a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from extracts of rhizoma chuanxiong and radix puerariae; preferentially, the weight ratio of rhizoma chuanxiong to radix puerariae is 1:1. In application of the traditional Chinese medicine composition in preparing medicine for treating cerebral stroke, preferentially, the cerebral stroke is ischemic cerebral stroke.

Description

technical field [0001] The invention belongs to the field of pharmacology, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating cerebral apoplexy. Background technique [0002] Cerebral ischemic stroke, also known as ischemic cerebral infarction, is characterized by high morbidity, disability and mortality, and is a disease that seriously endangers human life [1]. According to the latest data released by the American Heart Association (AHA), there are approximately 795,000 new or recurrent stroke cases in the United States every year. On average, one stroke occurs every 40 seconds, and one patient dies of stroke every 4 minutes. The mortality rate exceeds 60%. Ischemic stroke accounts for approximately 87% of all stroke cases [2]. Studies have shown that the occurrence of ischemic stroke is mainly due to the reduction of blood flow restriction of blood vessels and their branch vessels in spe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61P9/10A61P3/06A61P7/02
CPCA61K36/236A61K36/488A61P3/06A61P7/02A61P9/10A61K2300/00
Inventor 赵洁吴芃蔡铮陈润芝
Owner SOUTHERN MEDICAL UNIVERSITY
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