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A kind of combined excipient of traditional Chinese medicine extract and its preparation method and application

A technology for extracts and traditional Chinese medicines, which is applied in the field of joint excipients of traditional Chinese medicine extracts and their preparation, can solve the problems of easy agglomeration, poor operability, low critical relative humidity, etc., and achieves hard agglomeration and reduced hygroscopicity. , the effect of increasing the critical relative humidity

Active Publication Date: 2021-01-26
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the combined auxiliary material of the Chinese medicine extract provided by the present invention can effectively solve the problem that the dry product of the Chinese medicine extract obtained by drying the current Chinese medicine extract has strong hygroscopicity, low critical relative humidity, and is easy to stick into agglomerates, and the production can be achieved. Technical flaws with poor operability

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  • A kind of combined excipient of traditional Chinese medicine extract and its preparation method and application
  • A kind of combined excipient of traditional Chinese medicine extract and its preparation method and application
  • A kind of combined excipient of traditional Chinese medicine extract and its preparation method and application

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Embodiment 1

[0034] This embodiment discloses a preparation method of a Chinese medicine extract combined auxiliary material, comprising the following steps: mixing sodium carboxymethyl starch, crospovidone and low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, crospovidone The mass ratio of ketone and low-substituted hydroxypropyl cellulose is 3:2:5, and the joint auxiliary material of the Chinese medicine extract is prepared.

Embodiment 2

[0036] In this embodiment, six groups are set, which are respectively conventional group, experimental group 1, experimental group 2, experimental group 3, experimental group 4 and control group, and the components of each group are set as follows:

[0037] Conventional group: First, put 100kg of high-viscosity traditional Chinese medicine mixed extraction concentrate with a solid content of about 20% in a preparation tank with paddle leaves, stir and heat to 60-70°C. Continue to stir, slowly add 8kg (40% of the dry product weight of the high-viscosity traditional Chinese medicine mixed extraction concentrate) of maltodextrin to the preparation tank, mix with the high-viscosity traditional Chinese medicine mixed extraction concentrated solution, and fully stir at 60°C to 70°C for 30 minutes , according to spray-drying conditions to prepare routine group samples.

[0038]Experimental group 1: Put 100kg of high-viscosity traditional Chinese medicine mixed extraction concentrate ...

Embodiment 3

[0049] The present embodiment carries out the mensuration of critical relative humidity to the routine group that embodiment 2 prepares, experimental group 1-4 and control group:

[0050] 1. Determination of moisture absorption equilibrium time

[0051] Take a glass desiccator filled with a NaCl supersaturated solution at the bottom (in order to ensure the NaCl solution is saturated, there should be excess NaCl at the bottom of the desiccator), with 6 weighing bottles built into the desiccator, and reach a constant weight in a 25°C constant temperature drying oven. Take 1g of each sample from the routine group, experimental group 1-4 and control group, put it in a weighing bottle, weigh it accurately, open the weighing cover, put it in the upper part of the desiccator, and store it in a constant temperature drying oven at 25°C, every 24h Weigh once and calculate the moisture absorption rate at different times.

[0052] 3.1 Moisture absorption equilibrium time

[0053] Moistu...

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Abstract

The invention belongs to the technical field of medicine and health food preparation, and in particular relates to a combined auxiliary material of a traditional Chinese medicine extract and a preparation method and application thereof. The invention provides a combination auxiliary material of traditional Chinese medicine extract, which comprises: sodium carboxymethyl starch, crospovidone and low-substituted hydroxypropyl cellulose. The invention also discloses the application of the combined auxiliary material of the Chinese medicine extract in reducing the hygroscopicity of the dried product of the Chinese medicine extract and improving the formability and stability of the dried product of the Chinese medicine extract. The invention solves the technical defects that the dry product of the traditional Chinese medicine extract obtained by drying the traditional Chinese medicine extract has strong hygroscopicity, low critical relative humidity, easy to stick into agglomerates, and poor production operability.

Description

technical field [0001] The invention belongs to the technical field of medicine and health food preparation, and in particular relates to a combined auxiliary material of a traditional Chinese medicine extract and a preparation method and application thereof. Background technique [0002] Chinese patent medicines and health care products are spray-dried powders obtained by extracting, concentrating, and spray-drying Chinese medicinal materials. Generally, maltodextrin, edible corn starch, pregelatinized starch, sodium carboxymethyl starch, and Excipients such as gelatin and gum arabic solidify the Chinese medicine extract to form a spray-dried powder. Among them, maltodextrin is the most widely used. This type of method is versatile for general Chinese medicine extracts, but for viscous Chinese medicine extracts or mixed extracts containing a large amount of polysaccharides, the prepared spray-dried powder has strong hygroscopicity, low critical relative humidity, and is ea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/36A61K47/32
CPCA61K47/32A61K47/36A61K47/38
Inventor 胡芳张铭辉陈浩璇黄远英欧晓玲殷光玲袁训贤张旭光
Owner BY HEALTH CO LTD