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Method for preparing three-dimensional microfluidic chip

A microfluidic chip, three-dimensional technology, applied in the field of microfluidics, can solve problems such as rough surface, difficult to realize, and opaque materials

Inactive Publication Date: 2018-09-21
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) Only microchannels with planar structures can be made. To make a three-dimensional structure can only be realized by superimposing layers of planar structures, and it is difficult to realize a slightly complex structure;
[0006] (2) The processing steps of the substrate are complex and expensive
However, 3D printed materials are often not transparent, and the microscopic surface is relatively rough, which is not conducive to the experimental observation of the internal fluid flow.

Method used

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  • Method for preparing three-dimensional microfluidic chip
  • Method for preparing three-dimensional microfluidic chip
  • Method for preparing three-dimensional microfluidic chip

Examples

Experimental program
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Effect test

Embodiment 1

[0041] 1) Use the commercial computer-aided design software Solidworks to draw a three-dimensional model of the internal channel of the microfluidic chip with internal hollow features, and the three-dimensional model has reserved parts for subsequent resection. The model is as follows: figure 2 shown. The flow channel model is helical, which can be used for micro-mixing operations, and has higher mixing efficiency than planar structures;

[0042] 2) Use a 3D printer, load polyvinyl alcohol (PVA) consumables, import the 3D model into the 3D printer, and obtain a 3D printing model of polyvinyl alcohol (PVA) material. Turn on the oven, set to 80°C and preheat for 20 minutes. After the 3D printing is completed, dip the polyvinyl alcohol (PVA) 3D printed model in cold water at 10 degrees Celsius, and quickly put it in a preheated oven for drying. The temperature of the oven is set at 45 degrees Celsius;

[0043] 3) Prepare a mixture of polydimethylsiloxane (PDMS) and curing agen...

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Abstract

The invention discloses a method for preparing a three-dimensional microfluidic chip, and belongs to the technical field of microfluidics. Water-soluble materials are selected, and a hollow model of internal three-dimensional passageways of the microfluidic chip is processed based on a 3D printing technology; the coarse degree of the outer surface of the hollow model is reduced through dipping andrapid drying process; secondary pouring is conducted on polydimethylsiloxane, after curing is conducted, reserved edge banding of the outlet and inlet of the hollow structure is cut, and the water-soluble materials are dissolved by using hot water bathing to obtain the microfluidic chip with a three-dimensional passageway structure and a smooth inner wall surface. The method has the advantages oflow implementing difficulty, simple procedures, low cost and the like, the prepared three-dimensional microfluidic chip has a highly complicated three-dimensional structure, the coarse degree of theinner surface of the three-dimensional microfluidic chip is low, and the visibility degree is high.

Description

technical field [0001] The invention relates to a method for manufacturing a three-dimensional microfluidic chip, which belongs to the field of microfluidic technology. Background technique [0002] Microfluidics integrates the functions of biological and chemical laboratories into a chip with a size of a few centimeters, which can effectively realize the miniaturization, automation, integration and portability of various functions such as analysis, detection and reaction. Now it has become a brand-new research field intersecting multiple disciplines such as biology, chemistry, medicine, electronics, machinery and materials. [0003] The microfluidic chip is an important platform for the realization of microfluidic technology. The main feature of the microfluidic chip is that its internal microchannels, reaction chambers, capture chambers and other structural dimensions are all on the micron scale. The increase of its specific surface area makes the fluid show different phy...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/502707B01L2200/12B01L2300/0874
Inventor 刘赵淼王飓赵圣伟逄燕
Owner BEIJING UNIV OF TECH
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