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In-situ cross-linked hyperbranched polyether hydrogel for long-term filling in the eye and preparation method thereof

A technology of hyperbranched polyether and in-situ cross-linking, which is applied in prosthetics, tissue regeneration, medical science, etc., can solve the problems of intraocular tissue toxicity, limited visual function recovery, unfavorable clinical application, etc., and achieve good hydrophilicity And biocompatibility, meet the clinical operation requirements, solve the effect of long gelation time

Active Publication Date: 2019-11-12
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although silicone oil is a relatively inert material, long-term filling of silicone oil is prone to emulsification. The emulsified silicone oil is toxic to intraocular tissues, which increases the postoperative complications of retinal vitreous surgery to a certain extent, affects the surgical effect, and limits vision. Restoration of function
However, when traditional polymer hydrogels are used for long-term artificial vitreous filling, there are problems such as long gelation time, high gelation concentration, easy degradation, and biological toxicity, which are not conducive to clinical application. Therefore, it is urgent to find an ideal Artificial vitreous filler for long-term filling in the eye

Method used

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  • In-situ cross-linked hyperbranched polyether hydrogel for long-term filling in the eye and preparation method thereof
  • In-situ cross-linked hyperbranched polyether hydrogel for long-term filling in the eye and preparation method thereof
  • In-situ cross-linked hyperbranched polyether hydrogel for long-term filling in the eye and preparation method thereof

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Embodiment 1

[0032] The in-situ cross-linked hyperbranched polyether hydrogel that can be used for long-term filling in the eye, the preparation method thereof comprises the following steps:

[0033] (1) Preparation of hyperbranched polyether polyol

[0034] Potassium methoxide and trimethylolpropane are mixed at a molar ratio of 1:1 to form an initiator system to initiate the ring-opening polymerization of glycidol to obtain hyperbranched polyether polyol (specifically, hyperbranched polyglycidyl ether) ; Wherein, the molar ratio of trimethylolpropane and glycidyl alcohol is 1:50, the reaction temperature is 60°C, and the reaction time is 24h;

[0035] (2) Preparation of hyperbranched polyether-multi-arm polyethylene glycol

[0036] Potassium methylate and hyperbranched polyether polyol are mixed at a molar ratio of 1:2 to form an initiator system to initiate ring-opening polymerization of ethylene oxide to obtain hyperbranched polyether-multi-arm polyethylene glycol; wherein, hyperbranc...

Embodiment 2

[0041] The in-situ cross-linked hyperbranched polyether hydrogel that can be used for long-term filling in the eye, the preparation method thereof comprises the following steps:

[0042] (1) Preparation of hyperbranched polyether polyol

[0043] Potassium methoxide and trimethylolpropane are mixed at a molar ratio of 1:5 to form an initiator system to initiate the ring-opening polymerization of glycidol to obtain hyperbranched polyether polyol (specifically, hyperbranched polyglycidyl ether) ; Wherein, the molar ratio of trimethylolpropane and glycidyl alcohol is 1:50, the reaction temperature is 80°C, and the reaction time is 24h;

[0044] (2) Preparation of hyperbranched polyether-multi-arm polyethylene glycol

[0045] Potassium methylate and hyperbranched polyether polyol are mixed at a molar ratio of 1:5 to form an initiator system to initiate ring-opening polymerization of ethylene oxide to obtain hyperbranched polyether-multi-armed polyethylene glycol; wherein, hyperbra...

Embodiment 3

[0050] The in-situ cross-linked hyperbranched polyether hydrogel that can be used for long-term filling in the eye, the preparation method thereof comprises the following steps:

[0051] (1) Preparation of hyperbranched polyether polyol

[0052] Potassium methylate and pentaerythritol are mixed at a molar ratio of 1:2 to form an initiator system to initiate the ring-opening polymerization of glycidol to obtain hyperbranched polyether polyols (specifically hyperbranched polyglycidyl ether); wherein, pentaerythritol The molar ratio with glycidyl alcohol is 1:30, the reaction temperature is 50°C, and the reaction time is 48h;

[0053] (2) Preparation of hyperbranched polyether-multi-arm polyethylene glycol

[0054] Potassium methylate and hyperbranched polyether polyol are mixed at a molar ratio of 1:3 to form an initiator system to initiate ring-opening polymerization of ethylene oxide to obtain hyperbranched polyether-multi-arm polyethylene glycol; wherein, hyperbranched The ...

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Abstract

The invention provides an in-situ cross-linked hyperbranched polyether hydrogel which can be used for long-term filling in the eye and a preparation method thereof. The preparation method comprises the following steps: mixing a metal compound containing active hydrogen with a hydroxyl or amino compound , and then react with epoxy compounds to prepare hyperbranched polyether polyols; mix metal compounds containing active hydrogen with hyperbranched polyether polyols, and then react with ethylene oxide to prepare hyperbranched polyether-multi-armed polyols Ethylene glycol; hyperbranched polyether multi-arm polyethylene glycol is reacted with double bond-containing molecules and mercapto-containing molecules respectively, and the two reaction products are cross-linked in situ to prepare hyperbranched polyethers Hydrogels. The hyperbranched polyether hydrogel prepared by the invention has good stability, biocompatibility and light transmittance, and can quickly form a gel at a lower concentration.

Description

technical field [0001] The invention belongs to the technical field of intraocular fillings, and in particular relates to an in-situ cross-linked hyperbranched polyether hydrogel which can be used for long-term intraocular filling and a preparation method thereof. Background technique [0002] The vitreous is a non-renewable transparent gel in the eyeball. In the vitrectomy for vitreoretinal diseases, after the vitreous is removed, a vitreous substitute needs to be injected into the eye to support the retina, repair eye damage, rebuild visual function and prevent eyeballs from shrinking. At present, air, inert gas, heavy water, silicone oil, etc. are commonly used clinically. Except for silicone oil, all of the above are short-term applications. However, although silicone oil is a relatively inert material, long-term filling of silicone oil is prone to emulsification. The emulsified silicone oil is toxic to intraocular tissues, which increases the postoperative complicatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08G65/28C08G65/332C08G65/326A61L27/52A61L27/50A61L27/18
CPCA61L27/18A61L27/50A61L27/52A61L2430/16C08G65/2609C08G65/326C08G65/3324C08G2650/20C08G2650/30C08J3/075C08J3/246C08J2371/02C08J2471/02C08L71/02
Inventor 曹俊张漫何艳梅张学全李莉蒲雨吉何斌
Owner SICHUAN UNIV