Movable mobile phase control system with double gradient adjustment function and treatment method and application of control system

A technology of control system and processing method, which is applied in the direction of using material absorption and weighing, using sonic/ultrasonic/infrasonic waves to analyze fluids, and using sonic/ultrasonic/infrasonic waves for material analysis, etc. Slow development and other problems, to achieve the effect of meeting the requirements of the connection interface, easy maintenance, and high control accuracy

Pending Publication Date: 2018-10-02
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Mainly in terms of mobile phase control, the development is relatively slow. DPI uses a unit, a dual-channel syringe pump and a six-way valve injector, which cannot perform gradient changes in the mobile phase; QCM uses a one-way peristaltic pump and relies on pipeline switching to achieve sample injection. ; AFM has only a liquid sample cell, no pump system, relying on a manual syringe to advance the mobile phase
Therefore, the mobile phase control system of existing instruments and equipment lacks precise control of the liquid environment, and cannot realize gradient changes in solution composition, such as ionic strength and pH, and cannot realize the adjustment of various solution parameters.
In the field of biomaterials research, many research contents involve the dynamic change of the interface environment. For example, in the process of protein separation and purification and the administration of protein pharmaceutical preparations, the interface environment of protein molecules is dynamically changed, and the existing interface Characterization equipment cannot effectively simulate the solid-liquid interface environment in the actual system
[0004] Some existing liquid phase control systems, such as liquid phase pumps, not only have a large dead volume, but cannot meet the needs of existing interface analysis equipment for rapid and accurate mobile phase gradient changes; moreover, large shear forces are likely to cause inactivation of biological macromolecules, so it is not possible to Mobile phase control system suitable for biomacromolecule characterization equipment

Method used

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  • Movable mobile phase control system with double gradient adjustment function and treatment method and application of control system
  • Movable mobile phase control system with double gradient adjustment function and treatment method and application of control system
  • Movable mobile phase control system with double gradient adjustment function and treatment method and application of control system

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Embodiment 1

[0055] This embodiment provides a mobile phase control system with dual gradient adjustment function and its processing method, the system is as figure 1 As shown, it includes a control assembly, a syringe pump group 31 , a gradient mixer 41 and a sampling valve 51 connected in sequence.

[0056] Wherein, the control assembly includes a control device 11 and a main controller 21 connected in sequence, the control device 11 and the main controller 21 are connected by a network cable, the control assembly and the injection pump group 31 are connected by an electronic circuit, and the injection pump group 31. The gradient mixer 41 and the sampling valve 51 are sequentially connected through a liquid connecting pipe.

[0057] Described control device 11 selects computer for use, and main controller 21 is made up of core control board 211 and IO board 212, as figure 2 As shown, the core control board 211 and the IO board 212 are integrated together, wherein the core control board...

Embodiment 2

[0068] This embodiment provides a mobile phase control system with dual-gradient adjustment functions and its processing method. The structure and processing method of the system refer to Embodiment 1, the difference is that the single-channel syringe pump is a split type syringe pump, The volume of the syringe is 0.5 mL.

Embodiment 3

[0070] This embodiment provides a mobile phase control system with dual gradient adjustment functions and its processing method. The structure and processing method of the system refer to Embodiment 1, except that the volume of the syringe is 200 mL.

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Abstract

The invention provides a movable mobile phase control system with a double gradient adjustment function, and a treatment method and an application of the control system. The system comprises a controlcomponent, an injection pump group, gradient mixers and introduction valves. The mobile phase control system is suitable as a mobile phase system of an analysis and characterization instrument in a biological material study to simulate a complicated solid-liquid interface environment and is applied to the field of interface analysis, characterization and detection.

Description

technical field [0001] The invention belongs to the field of liquid phase pumps, and relates to a mobile phase control system and its processing method and application, in particular to a mobile phase control system with dual gradient adjustment function and its processing method and application. The system is suitable as a mobile phase system for analytical and characterization instruments in biomaterial research to simulate complex solid-liquid interface environments, and is used in the field of interface analysis, characterization and detection. Background technique [0002] In recent years, the interface analysis and detection technology has been developing continuously, and its main development direction is to increase the scanning rate, improve the detection accuracy and provide more types of detection chips. At present, the widely used interface analysis instruments in biomaterial research include atomic force microscope (AFM), dual polarization interference interface...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N29/02G01N5/02
CPCG01N5/02G01N29/022
Inventor 马光辉宋翠魏炜葛佳李秀男李强周炜清
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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