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Compound tannic acid antidote for F-2 toxin poisoning and application of compound tannic acid antidote

An antidote, F-2 technology, applied in the direction of antidote, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem that the detoxification effect enhances the activity of poisoned ovarian granulosa cells, the detoxification effect of F-2 toxin is not comprehensive, and the detoxification effect is insufficient. The effect is not significant enough to achieve the effects of improving animal production performance, improving the immune function of the body, and repairing anti-oxidative damage.

Active Publication Date: 2018-10-16
CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0003] The antidote of the F-2 toxin disclosed in the prior art is vitamin-E (V-E). Although V-E has a detoxification effect on the F-2 toxin, its detoxification effect is limited to enhancing the activity of poisoned ovarian granulosa cells and reducing the number of cells. Malondialdehyde (MDA) content, the detoxification effect of V-E on F-2 toxin is not comprehensive enough, and the detoxification effect is not significant enough

Method used

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  • Compound tannic acid antidote for F-2 toxin poisoning and application of compound tannic acid antidote
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  • Compound tannic acid antidote for F-2 toxin poisoning and application of compound tannic acid antidote

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[0019] The present invention provides a preparation method of an antidote for F-2 toxin poisoning described in the above technical proposal, comprising the following steps: mixing tannic acid, astragalus polysaccharide, glycyrrhizin, and mulberry extract, grinding and drying to obtain Antidote for F-2 toxin poisoning. The present invention has no specific limitation on the grinding method, the particle size of the ground material, the drying method and the water content of the antidote after drying.

[0020] The present invention provides the application of the antidote for F-2 toxin poisoning described in the above technical scheme in the preparation of animal medicine for F-2 toxin poisoning.

[0021] The present invention provides the application of the antidote for F-2 toxin poisoning described in the above technical solution in the preparation of drugs for inhibiting the expression of estrogen receptors in vivo; the estrogen receptors are preferably ERα or ERβ.

[0022] ...

Embodiment 1

[0025] According to the weight ratio of tannic acid: astragalus polysaccharide: glycyrrhizin: mulberry extract = 3:1:1:1, the mixture is ground into powder to obtain the antidote for F-2 toxin poisoning.

[0026] When pigs are poisoned by F-2 toxin, add 0.05-0.1% of the above-mentioned antidote to the ration by weight, stir evenly and then feed.

Embodiment 2

[0028] According to the weight ratio of tannic acid: astragalus polysaccharide: glycyrrhizin: mulberry extract = 47: 15: 15: 15, the mixture is ground into powder to obtain the antidote for F-2 toxin poisoning.

[0029] In order to verify the detoxification effect of the antidote of the present invention on F-2 toxin poisoning, the following test is carried out: 24 Du × long × large three-way hybrid young sows are divided into 4 groups, 6 repetitions in each group, and 1 head in each repetition pig. Control group (normal diet), exposure group (containing 240 μg / kg F-2 toxin in the diet), treatment group 1 (containing 240 μg / kg F-2 toxin+accounting for 0.1% tannin in the diet weight in the diet) acid), treatment group 2 (240 μg / kg F-2 toxin+accounting for 0.1% antidote of the present invention by weight in the diet), and the test time was 24 days. After the start of the experiment, observe and record the swelling of the vulva of the pigs every day, measure the length (a) and w...

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Abstract

The invention provides a compound tannic acid antidote for F-2 toxin poisoning and application of the compound tannic acid antidote, and belongs to the technical field of F-2 toxin poisoning antidotes. The antidote is prepared from the following raw materials in parts by weight: 40 to 50 parts of tannic acid, 10 to 20 parts of astragelus polysaccharide, 10 to 20 parts of glycyrrhizin and 10 to 20parts of mulberry extract. The antidote disclosed by the invention takes the tannic acid as a main component and matches the tannic acid with the astragelus polysaccharide, the glycyrrhizin and the mulberry extract, so that the expression of an estrogen receptor in vivo can be effectively inhibited and the estrogen-like toxicity of F-2 toxin is antagonized; meanwhile, antioxidant damage can also be repaired and the immune function of a body is improved, so that the F-2 toxin toxicity can be fully and effectively antagonized and further the production performance of animals is improved.

Description

technical field [0001] The invention relates to the technical field of F-2 toxin poisoning antidote, in particular to a compound tannic acid antidote for F-2 toxin poisoning. Background technique [0002] F-2 toxin, also known as Zearalenone (ZEA), is a secondary metabolite produced by Fusarium graminearum, Gibberella zea and other molds, and has certain toxicity. Widely present in some cereal crops, such as corn, sorghum and wheat, especially corn and its by-products. F-2 toxin can cause strong pollution to feed raw materials and feed itself, thus causing serious harm to animal organisms. F-2 toxin has an estrogen-like effect and will affect the reproductive function of animals, among which pigs are the most sensitive. F-2 toxin enters the body and is mainly distributed in tissues and organs with rich distribution of estrogen receptors, such as testicular stromal cells, follicles and uterus etc. When sows are poisoned, they mainly appear redness and swelling of vulva, ut...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P39/02A61K31/7024A61K31/715A61K31/704
CPCA61K31/7024A61K31/704A61K31/715A61K36/605A61P39/02A61K2300/00
Inventor 邬静易金娥文利新袁志航屠迪
Owner CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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