A kind of flavonoid compound in traditional Chinese medicine compound and its preparation method and application
A technology of flavonoids and traditional Chinese medicine, applied in the preparation of sugar derivatives, chemical instruments and methods, drug combinations, etc., can solve problems such as the physical burden of patients and the psychological impact of patients
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[0037] The preparation method of flavonoids in the described Chinese medicine compound comprises the following steps:
[0038] (1) Prepare Chinese medicine compound:
[0039] The traditional Chinese medicine compound includes bletilla striata, chuanxiong, licorice, comfrey, salvia miltiorrhiza, angelica, fangfeng, digupi and tougucao;
[0040] (2) Extraction:
[0041] After decocting a dose of traditional Chinese medicine compound in ultrapure water, harvesting the Chinese medicine water extract, concentrating under reduced pressure, extracting the concentrated solution with ethyl acetate, and obtaining an ethyl acetate extract after concentrating;
[0042] (3) Rough classification:
[0043] Add the ethyl acetate extract to ultrapure water, and use ultrasound to promote dissolution. After being adsorbed by a macroporous adsorption resin, use distilled water, 20-30% ethanol, 50-60% ethanol, 70-80% ethanol and 90% ethanol in sequence. ~ 100% ethanol to elute the sample from t...
Embodiment 1
[0058] The preparation method of apigenin-7-butene-glucoside
[0059] (1): Composition of traditional Chinese medicine compound: The composition of traditional Chinese medicine compound in this research is: Bletilla striata 12g, Chuanxiong 9g, Licorice 6g, Comfrey 15g, Salvia miltiorrhiza 12g, Angelica 10g, Fangfeng 10g, Digupi 12g, and Scutellaria 6g. It has good clinical curative effect and is an excellent formula for curing vitiligo.
[0060] (2): Extraction: Soak a dose of traditional Chinese medicine compound (92g) in 1L of ultrapure water for 2 hours, then boil it in a medicine pot for 3 hours. After decocting, 280 mL of Chinese medicinal water extract was harvested and concentrated under reduced pressure at 55°C. Extract according to concentrated solution: ethyl acetate=1:(2~5)(V:V), repeat 2~3 times, combine ethyl acetate extract, concentrate to obtain ethyl acetate extract.
[0061] (3): Coarse fractionation: take AB-8 resin about 10 times the weight of the ethyl ac...
Embodiment 2
[0083] (1): Chinese medicine compound composition: same as embodiment 1.
[0084](2): Extraction: Soak a dose of traditional Chinese medicine compound (92g) in 2L of ultrapure water for 2 hours, then boil it in a medicine pot for 3.5 hours over low heat. After decocting, 400 mL of Chinese medicinal water extract was harvested and concentrated under reduced pressure at 60°C. Extract according to concentrated solution: ethyl acetate = 1:2 (V:V), repeat 2 to 3 times, combine ethyl acetate extracts, and concentrate to obtain ethyl acetate extracts.
[0085] (3): Coarse fractionation: take AB-8 resin about 6 times the weight of the ethyl acetate extract. Put the resin into a beaker, add enough absolute ethanol to impregnate for 4 hours. Wash it repeatedly with ultrapure water until there is no alcohol smell. Wet sample loading method was used. Add ultrapure water to the extract of ethyl acetate extract, ultrasonically promote dissolution, and add the solution to the prepared re...
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