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Application of linalool compound in preparation of medicine for treating rheumatoid arthritis

A technology for treating rheumatoid arthritis, which is applied in the field of linalool compound, preparation and treatment of rheumatoid arthritis drugs, can solve problems such as large toxic and side effects of medication, and achieve the effects of medication safety, increasing cure rate, and reducing foot swelling.

Inactive Publication Date: 2018-10-26
SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantages of existing drugs for treating rheumatoid arthritis, such as large drug toxicity and side effects and strong drug compliance, and provide a drug that can produce low toxicity, high efficiency, and multiple action targets for the treatment of rheumatoid arthritis diseases. Application of compound linalool in preparation of medicine for treating rheumatoid arthritis

Method used

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  • Application of linalool compound in preparation of medicine for treating rheumatoid arthritis
  • Application of linalool compound in preparation of medicine for treating rheumatoid arthritis
  • Application of linalool compound in preparation of medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Anti-inflammatory and analgesic effects of linalool on rheumatoid arthritis

[0028] In this example, the applicant took the complete Freund's adjuvant-induced arthritis rat animal model as the research object, and carried out the following animal simulation experiments to study the therapeutic effect of linalool on foot swelling and foot pain caused by rheumatoid arthritis .

[0029] The specific experimental operation is as follows:

[0030] S1, modeling and grouping

[0031] Sixty SPF grade male SD rats weighing (170±10) g were randomly numbered, and 10 rats were selected as the blank control group according to the random number table, and the remaining 50 rats were injected with CFA to establish AA model rats. For the modeling method, please refer to Qiao Weiping, Jin He, Xu Lin. Animal Experimental Research on Rheumatoid Arthritis Treated by Nuxychia [J]. Jilin Traditional Chinese Medicine, 2009, 29(2): 168-169. After the rats were fixed, CFA was injected subcut...

Embodiment 2

[0060] After the experiment in Example 1, the rats were anesthetized, and the blood of the rats was collected from the abdominal aorta, and the thymus, spleen, left and right ankle joints were stripped off, and placed in corresponding required solutions respectively for future use.

Embodiment 21

[0061] Embodiment 2.1 The influence of linalool on the pathological changes of ankle joints in AA rats

[0062] Take the above spare left and right ankle joints of AA rats for H.E staining test, and the H.E staining test results are as follows: figure 1 Shown:

[0063] Blank control group: the synovium was thin and complete, composed of 1-2 layers of synoviocytes, no tissue edema, inflammatory cell infiltration and angiogenesis, the cartilage surface was smooth, no bone destruction, the joint structure was complete, and the proportion of the joint space was normal (See figure 1 (a)).

[0064] Model control group: synovial epithelial cells were slightly hyperplastic, 3 to 5 layers of synovial cells were visible, and the arrangement was slightly disordered, with or without a small amount of inflammatory cell infiltration, the gaps were narrowed in some joints, the surface of the articular cartilage was smooth, and the structure was intact. Bone destruction was seen, and no in...

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Abstract

The invention belongs to the field of medicinal application invention, particularly discloses application of a linalool compound in preparation of a medicine for treating rheumatoid arthritis, and discloses the possibility of linalool serving as a natural medicinal material extract for achieving the remarkable effects of multi-target, low toxicity and high efficiency on rheumatoid arthritis, improving the cure rate for patients with rheumatoid arthritis and reducing administration varieties and dosage through a multi-action mechanism of relieving paw edema of an AA rat, reducing 50 percent ofpain threshold ED50 of the AA rat, relieving ankle joint pathologic change and immune organ pathologic change of the AA rat, inhibiting the proinfammatory cytokines expression level of IL-1beta, IL-6and IL-10 in serum of the AA rat and / or inhibiting expression of NF-kappa B / p65 protein in the ankle joint of the AA rat. The linalool compound has a remarkable progressive meaning when being appliedto preparation of medicine for treating rheumatoid arthritis.

Description

technical field [0001] The present invention relates to the invention field of medicine application, in particular to the application of linalool compound in the preparation of medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by joint synovitis, and it is also a common rheumatic disease in clinical practice. The main pathological features of arthritis are synovial tissue hyperplasia, inflammatory cell infiltration, pannus formation, and cartilage and bone destruction, which can eventually lead to joint deformity and loss of function. The prevalence rate is 0.32% to 0.36%, and women are more than men. At present, the treatment of RA mainly uses drugs to relieve joint symptoms, delay the disease, and protect joint function. -α inhibitors and IL-1 antagonists, etc., but most of the above-mentioned drugs are chemically synthesized drugs, which have relatively large toxic ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P19/02A61P29/00
CPCA61K31/045A61P19/02A61P29/00
Inventor 李晋奇何丹童荣生胡远王佳凤张舒涵李杰
Owner SICHUAN PROVINCIAL PEOPLES HOSPITAL
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