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Combined fungicide containing fludioxonil and N-(2-(2,4-dichlorophenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

A technology of chlorophenyl ether amide and fludioxonil, which is applied in the directions of fungicides, biocides, biocides, etc., can solve the problems of increasing the dosage and frequency of medication, accelerating the formation of drug-resistant pathogen groups, and the failure of chemical control of drugs. , to achieve the effect of simple method of use, less resistance to drugs, and wider application spectrum of disease prevention

Inactive Publication Date: 2018-11-02
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The proportion of these resistant individuals increases under the selection pressure of fungicides, resulting in a decline in the control effect of fungicides
In order to maintain the control effect, the dosage and frequency of medication are often increased, which further accelerates the formation of drug-resistant pathogen groups, eventually leading to the prevalence of drug-resistant diseases, and the complete failure of chemical control.

Method used

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  • Combined fungicide containing fludioxonil and N-(2-(2,4-dichlorophenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
  • Combined fungicide containing fludioxonil and N-(2-(2,4-dichlorophenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
  • Combined fungicide containing fludioxonil and N-(2-(2,4-dichlorophenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, indoor formula screening:

[0030] The determination of toxicity and synergistic coefficient is to dissolve the former drug of fludioxonil and the former drug of chlorophenyl ether amide respectively, configure the mother liquors of different ratios, and adopt the mycelia growth method to measure the inhibitory effect on Rhizoctonia solani (Table 1), Then calculate the EC 50 value and synergy factor. Results When the ratio of (A) fludioxonil from 1 to 9 and (B) chlorophenyl ether amide from 9 to 1 were compounded, they all showed obvious synergistic effect, and the SR coefficients were between 1.92 and 2.66. And when A:B is 1:19 or 19:1, both are additive, and SR are 1.05 and 1.18 respectively.

[0031] According to the main prevention and control objects, select the ratio of synergistic coefficient (SR) ≥ 1.5, and carry out appropriate dosage form processing.

[0032] Table 1. Formula screening for inhibiting Rhizoctonia solani

[0033]

[0034] ...

Embodiment 2

[0036] Embodiment 2, indoor formula screening:

[0037] The determination of toxicity and synergistic coefficient is to dissolve the former drug of fludioxonil and the former drug of chlorophenyl ether amide respectively, configure the mother liquors of different ratios, adopt the mycelia growth method to measure the inhibitory effect on botrytis cinerea (table 2), and then Calculate EC 50 value and synergy factor. Results When the ratio of (A) fludioxonil from 1 to 9 and (B) chlorophenyl ether amide from 9 to 1 were compounded, they all showed obvious synergistic effect, and the SR coefficients were between 2.05 and 2.68. And when A:B is 1:19 or 19:1, both are additive, and SR are 1.03 and 1.14 respectively.

[0038] According to the main prevention and control objects, select the ratio of synergistic coefficient (SR) ≥ 1.5, and carry out appropriate dosage form processing.

[0039] Table 2, the formula screening of inhibiting Botrytis cinerea

[0040]

[0041]

Embodiment 3

[0042] Embodiment 3, the formula screening of controlling boscalid resistant strawberry botrytis cinerea

[0043] The determination of toxicity and synergistic coefficient is to dissolve the former drug of fludioxonil and the former drug of chlorphenamide respectively, and configure them into different proportions of mother liquors, and adopt the mycelial growth method to measure the boscalid-resistant Botrytis cinerea (table 3 ) inhibition, and then calculate the EC 50 value and synergy factor. Results When the ratio of (A) fludioxonil from 1 to 9 and (B) chlorophenyl ether amide from 9 to 1 were compounded, they all showed obvious synergistic effect, and the SR coefficients were between 2.21 and 3.32. In the comparative test, the combination of (A) fludioxonil and (C) boscalid or (B) chlorphenamide and (C) boscalid, 1:1, 1:3 and No obvious synergistic effect was observed for 1:9, and the SR coefficients were between 0.91-0.99 and 1.04-1.44, respectively.

[0044] Table 3....

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PUM

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Abstract

The invention discloses a compound bactericide. The components and the content by weight of the compound bactericide are: 10% to 90% of fludioxonil and 90% to 10% of N-(2-(2,4-dichlorophenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide. The invention also discloses the use of the compound bactericide: preventing and treating vegetable and fruit tree diseases; in particular, preventing and treating plant diseases caused by Rhizoctonia and Botrytis fungi; more particularly, preventing and treating Boscalid resistant gray mold and thifluzamide resistant damping off.

Description

technical field [0001] The invention relates to a fungicide, in particular to a compound fungicide used for preventing and treating diseases caused by fungi of the genera Rhizoctonia and Botrytis. Background technique [0002] Rhizoctonia (Rhizoctonia) is an important class of parasitic soil-dwelling fungi, which do not produce asexual spores and have a wide range of hosts. Among them, rice sheath blight is a soil-borne disease caused by Rhizoctonia solani. It is one of the important diseases of rice and has become the first of the three major rice diseases in my country. It generally leads to a 10% to 30% reduction in rice production. , seriously up to 50%, brought huge losses to rice yield. At present, most of the control of rice sheath blight is controlled by caijinggangmycin, thiafuramide, etc., but after long-term use, there are problems such as large dosage and even a significant decline in control effect. Botrytis cinerea is caused by Botrytis fungi (mainly Botrytis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/36A01N43/56A01P3/00
CPCA01N43/36A01N43/56
Inventor 张传清刘亚慧戴德江吴鉴艳张宇
Owner ZHEJIANG FORESTRY UNIVERSITY
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