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Application of herba centellae extract in preparation of anti-fatigue drugs

A centella asiatica extract, anti-fatigue technology, applied in the direction of antitoxin, drug combination, pharmaceutical formula, etc., can solve the problem of rare anti-fatigue effect, etc., and achieve the effects of no toxic side effects, prolonging exercise time, and relieving fatigue.

Inactive Publication Date: 2018-11-02
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing studies of Centella asiatica, there are studies and discussions on the central nervous system and anti-oxidation effects, but there are few studies on its anti-fatigue effects

Method used

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  • Application of herba centellae extract in preparation of anti-fatigue drugs
  • Application of herba centellae extract in preparation of anti-fatigue drugs
  • Application of herba centellae extract in preparation of anti-fatigue drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Study on the Effect of Centella Asiatica Extract on Skeletal Muscle Fatigue.

[0024] 1.1 Experimental materials

[0025] 1.1.1 Experimental reagents

[0026] Centella asiatica extract was purchased from Xi'an Jinlv Bioengineering Technology Co., Ltd.

[0027] 1.1.2 Experimental materials

[0028] Adult giant toads used in the experiment were provided by the Experimental Animal Center of Zhejiang Ocean University.

[0029] 1.1.3 Experimental Instruments

[0030] Commonly used frog dissection surgical instruments; bioelectric input cables; RM6240 biological signal acquisition and processing system (Sichuan Chengyi); frog board; frog nails; iron stand; thick cotton thread; fine-tuning fixer; The distilled water and purified water used were self-made in the laboratory.

[0031] Electronic balance (Shunyu Hengping Instrument); analytical balance (Beijing Sartorius Scientific Instrument); muscle tension transducer (Sichuan Chengdu Instrument Factory, calibrat...

Embodiment 2

[0076] Example 2 Study on the Anti-fatigue Effect of Centella Asiatica Extract on Mice.

[0077] 2.1 Experimental materials

[0078] 2.1.1 Experimental animals

[0079] The mice used in this experiment were all provided by the Experimental Animal Center of Zhejiang Province (certificate number: SCXK (Zhejiang) 2014-0001). Before the start of the experiment, in the SPF animal laboratory, feed for one week at room temperature to adapt to the environment, set the humidity at 40-70%, and the ventilation frequency at 10-20 times / hour, and feed the mice at 6:00 pm every day , once a day, the distilled water in the drinking bottle was replaced once every two days, the mouse cage was changed twice a week, and new mouse bedding was replaced.

[0080] 2.1.2 Experimental reagents

[0081] Centella asiatica extract (produced by Xi'an Jinlv Bioengineering Technology Co., Ltd.); SOD kit, GSH kit, CAT kit (provided by Nanjing Jiancheng Bioengineering Institute).

[0082] 2.1.3 Experiment...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations. The invention discloses application of herba centellae extract in preparation of anti-fatigue drugs. The application provesin the experiment that the normal growth of herba centellae extract is not affected and has no toxic and side effects; the herba centellae extract can significantly prolong the exhaustive exercise time and relieve fatigue; the herba centellae extract has no liver toxicity and a high dose can increase the spleen index and relieve fatigue.

Description

technical field [0001] The invention relates to the technical field of medicaments, in particular to the application of centella asiatica extract in preparing anti-fatigue medicaments. Background technique [0002] Centella asiatica (L.) Urban is a perennial herb, also known as Luodeda, Bengdawan, Banbianqian, Umbelliferes, Umbelliferae, and Centella asiatica. The membranous leaves are herbaceous, round or reniform in shape, about 1-3 cm long and 1.5-5 cm wide; palmate veins are 5-7, raised on both sides, and the upper part of the vein is forked; the style is about 0.6 mm; filaments shorter than petals, as long as style. Centella asiatica was first recorded in "Shen Nong's Materia Medica". It is cold in nature, bitter in taste, and pungent. It has the effects of clearing away heat and dampness, detoxifying and reducing swelling. Geographically, it is mainly distributed in China, Malaysia, South Africa, India, Vietnam, Australia and other countries, while in my country, it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P39/00
CPCA61K36/23A61P39/00
Inventor 赵玉勤陈荫孙坤来王斌
Owner ZHEJIANG OCEAN UNIV
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