Composition for preparing propargyl ether
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- SICHUAN UNIV
- Publication Date
- 2018-11-02
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Abstract
Description
technical field
[0001] The invention relates to a composition for preparing propargyl ether, which belongs to the field of chemical synthesis. Background technique
[0002] Propargyl ether is widely used in organic synthesis and is a very important intermediate in organic synthesis. Since the terminal alkyne itself is a functional group that can be easily derivatized, various derivatives can often be synthesized conveniently through propargyl ethers. In addition, terminal alkynes are important functional groups for bioorthogonal reactions and can also be used in Raman spectroscopy.
[0003] Currently, propargyl ethers are usually prepared by substitution of propargyl alcohols with nucleophiles under transition metal catalyzed conditions. For example, Nicholas et al. reported an efficient method to achieve propargylation in the presence of cobalt complexing cations: propargyl alcohol with Co 2 (CO) 8 Form Co first 2 (CO) 6 The propargyl alcohol complex, then forms a car...