344 results about "Copper catalyzed" patented technology

The invention relates to the field of catalysts, in particular to a preparation method of a green and efficient copper catalyst. Comprising the following steps: (1) mixing basic cupric carbonate, ammonia water and water, adding ammonium salt at the same time, and preparing a copper ammonia solution as a precursor solution at room temperature; (2) mixing the precursor solution with a carrier or a carrier precursor to realize active component loading and catalyst preparation; and (3) filtering, washing, drying and roasting the mixed system in the step (2) to prepare the copper-based catalyst. According to the preparation method of the copper ammonia complexing precursor solution, preparation of the copper ammonia complexing solution at room temperature can be achieved, heating operation in the precursor preparation process is avoided, meanwhile, the nitrogen content of the system and nitrogen emission in the subsequent roasting process can be reduced by preparing the copper-based catalyst through the basic copper carbonate precursor, and efficient and green preparation of the catalyst is achieved.

The invention discloses a graphite diacetylene / copper oxide composite material cocatalyst and a co-production preparation process and application thereof. Graphite diyne has a two-dimensional layered structure and is composed of sp and sp hybridized carbon atoms, a periodically distributed structure is formed, and excellent electron transmission performance and pore structure are shown. An existing graphite diacetylene synthesis method is complex and high in cost, large-scale application of the graphite diacetylene in the industrial field is seriously restricted, the potential value of a copper catalyst cannot be fully exerted, and resource waste is caused. According to the invention, through a simple and efficient co-production process, co-production of graphite diyne and copper oxide nanoparticles is realized for the first time, and the graphite diyne / copper oxide composite material is successfully prepared. The novel composite material can be used as a cocatalyst to effectively improve photocatalytic hydrogen production, and the hydrogen production performance can be comparable with that of noble metal photocatalysts such as Pt. The problems of tedious steps, high energy consumption, low yield and the like in a traditional preparation method are solved, and the preparation method has important application value in the field of high-performance photocatalysis.

The invention discloses a sgRNA-based method for modifying and regulating gene editing, which comprises the following steps: carrying out POC acylation modification on a 2 '-OH site of sgRNA to introduce an alkynyl marker to obtain sgRNA with alkynyl; the sgRNA with alkynyl and azide are subjected to copper-catalyzed azide-alkynyl cycloaddition reaction under the action of a copper catalytic reagent to form a stable chemical cross-linked structure, so that the activity of the sgRNA is quickly closed and adjusted. According to the method, alkynyl is introduced to sgRNA and is subjected to a CuAAC reaction with multi-azide to form stable crosslinking, so that the activity of the CRISPR-Cas9 system is accurately controlled. The innovative method not only can effectively control the gene editing activity on the basis of not destroying the original structure and function of RNA, but also can significantly improve the target specificity of the CRISPR system and reduce the risk of genome damage caused by non-specific cleavage.

The invention relates to a green preparation method of fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylaminopyridine, which comprises the following steps: step 1, Ullmann reaction: coupling 3-chloro-2-methyl-5-trifluoromethylpyridine (C1) and N-bromomethyl phthalimide (C2) in the presence of a copper catalyst and potassium tert-butoxide to generate an intermediate (C3); and step 2, hydrolysis reaction: hydrolyzing the intermediate (C3) in the presence of hydrazine sulfate and an alkaline condition to generate the fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylamino pyridine. The method has the advantages of short synthesis steps, easily available raw materials, no use of high-toxicity cyanogen compounds, low catalyst cost, difficult poisoning, recycling, simple post-treatment process, and less waste liquid generation, greatly reduces the production cost, improves the production safety, reduces the waste liquid discharge amount, and accords with the idea of green synthesis.

The invention discloses a recyclable porous copper / cuprous oxide filamentous catalytic material and also discloses a preparation method of the catalytic material, and the preparation method comprises the following steps: taking a copper wire and pre-treating the copper wire to remove surface oxides; performing zinc electrodeposition treatment on the copper wire to obtain a galvanized copper wire; carrying out solution treatment on the galvanized copper wire to obtain a porous copper precursor; then, the porous copper precursor is subjected to corrosion treatment, zinc in a plating layer is removed, and a porous copper catalyst carrier is obtained; and putting the porous copper catalyst carrier into a tubular furnace for high-temperature oxidation to obtain the Cu / Cu2O filamentous catalytic material. The catalytic material provided by the invention has the characteristics of recoverability and good catalytic performance. According to the method, cuprous oxide is generated by adopting a one-step high-temperature thermal oxidation method, and regulation and control parameters are few and easy to control in the process.

The invention discloses a novel method for synthesizing 1, 3-diketone organic matters, which comprises the following steps: by taking acyl chloride and silyl enol ether as raw materials, generating acyl free radicals through photo-induced copper catalysis, and carrying out free radical addition reaction on the acyl free radicals and silyl enol ether, thereby efficiently constructing 1, 3-diketone compounds. Compared with strong base, oxidant, high temperature and expensive metal catalyst required by the existing method, the method provided by the invention adopts the cheap and high-yield copper catalyst, so that the production cost is reduced, and the economic benefit is improved. In addition, the method has mild reaction conditions, easily available catalysts and raw materials, utilizes clean and sustainable light energy as driving force, is simple and convenient to operate, and is suitable for large-scale production. The invention provides an economic and environment-friendly innovative way for synthesizing the 1, 3-diketone compound, and has a wide application prospect.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.

The invention discloses a preparation method of a sacubitril intermediate, which comprises the following steps: taking N-tert-butoxycarbonyl-L-serine ester as an initial raw material, reacting with sulfonyl chloride under the catalysis of an alkaline substance to obtain N-(tert-butoxycarbonyl)-O-sulfonyl-L-serine ester, activating hydroxyl in the compound by sulfonate, and reacting with sodium hydroxide to obtain the sacubitril intermediate. The preparation method comprises the following steps: reacting (R)-3-([1, 1 '-biphenyl]-4-yl)-2-(tert-butoxycarbonyl) amino) propionate with a Grignard reagent under the catalysis of copper to generate (R)-3-([1, 1'-biphenyl]-4-yl)-2-(tert-butoxycarbonyl) amino) propionate, and finally reducing ester groups into hydroxyl groups under the action of a catalyst and a reducing agent to generate (R)-tert-butyl (1-([1, 1 '-biphenyl]-4-yl)-3-hydroxypropane-2-yl) carbamate. The preparation method has the advantages of simple preparation process route, cheap and easily available raw materials, short synthesis route, mild reaction conditions, simplicity and convenience in operation and high yield, and has better application value and economic benefit.

The invention relates to application of an amide ligand and a copper catalyst in preparation of an amino indazole piperidine compound. The indazole piperidine compound is prepared by reacting a halogen-substituted indazole piperidine compound with an ammonia reagent, the reaction is carried out under the action of an amide ligand and a catalyst, the amide ligand is # imgabs0, the structural formula of the amide ligand is # imgabs1 # or L-hydroxyproline, and the catalyst is a cuprous compound.

The invention discloses a titanium-oxygen cluster cavity confinement monatomic copper catalyst as well as a preparation method and application thereof, and relates to the field of material science and photoelectrocatalysis. The method for preparing the titanium oxide cluster cavity confinement monatomic copper catalyst comprises the following steps: firstly preparing a titanium oxide cluster with a large cavity structure, and then coordinating and anchoring copper ions and water molecules in a cavity by using the assistance of NaBH4 to obtain the titanium oxide cluster cavity confinement monatomic copper catalyst. According to the method, the Ti16 precursor is firstly synthesized, and then Cu is directionally anchored in the cavity through NaBH4-assisted reduction, so that the defect of non-uniform metal distribution caused by a traditional one-pot method is overcome, high yield and good reproducibility of the catalyst are realized, and industrial requirements are met. According to the titanium oxide cluster cavity confinement monatomic copper catalyst Ti16 cluster prepared by the method disclosed by the invention, a rigid cavity formed by an octagonal prism framework can efficiently anchor copper atoms, so that the problem of migration and agglomeration of metal sites in a traditional catalyst is avoided.

The invention discloses a hydrogen-fluorine atom doped graphdiyne material and a preparation method thereof, and relates to the technical field of carbon materials. According to the method, halogenated aromatic hydrocarbon and an alkynyl compound are taken as raw materials, a palladium catalyst and a copper catalyst are taken as a catalytic system, and an acetylenic bond of the alkynyl compound and the halogenated aromatic hydrocarbon are subjected to a Sonogashira coupling reaction to obtain the hydrogen-fluorine-doped graphite alkynyl material. The graphdiyne material provided by the invention has a large pore diameter, multiple active sites and high thermal stability and chemical stability, so that the hydrofluorine-doped graphdiyne material has excellent electrochemical energy storage property, shows reversible capacity of 1155mAh g <-1 > under 0.05 Ag <-1 > when being used as a negative electrode of a lithium ion battery, and can be used as a negative electrode of the lithium ion battery. And the density is almost 3 times that of a commercial graphite negative electrode material (300-350mAh g <-1 >). The application of the graphdiyne material in the field of electrochemical energy storage is obviously promoted.

The invention discloses an oxyhalide atom cluster modified copper catalyst for electrochemical carbon dioxide reduction as well as a preparation method and application of the oxyhalide atom cluster modified copper catalyst, and aims to solve the problems of low activity, poor product selectivity and insufficient stability caused by catalyst reconstruction of a copper-based catalyst. According to the oxyhalide atom cluster modified copper-based catalyst, an oxyhalide atom cluster BiOX or MOCl is deposited on the surface of a metal active center copper-based material, and then negative voltage is applied in a CO2 gas atmosphere for reduction treatment, so that the oxyhalide atom cluster modified copper catalyst is formed. The general chemical formula of the oxyhalide atom cluster modified copper catalyst is BiOX / Cu or MOCl / Cu. The prepared oxyhalide cluster modified copper nano-catalyst has outstanding activity, selectivity and stability, has good multi-carbon Faraday efficiency in the electrochemical carbon dioxide reduction process, and has long-time stability, and FEC < 2 + > is larger than 75%.

The present invention discloses a method for preparing an indolinone compound containing a quaternary carbon center. The target compound is obtained by subjecting N-arylacrylamide to an intramolecular tandem oxidative cyclization reaction initiated by the addition of an intramolecular alkyl radical with a tertiary alkane in the presence of a copper catalyst. This novel synthetic route for indolinone compounds containing a quaternary carbon center offers advantages such as high efficiency, relatively mild reaction conditions, a wide range of substrate applicability, and high atom and step economies, and has potential applications in pharmaceutical synthesis.

To provide a method for synthesizing a cyanide that is a precursor to a β-amino acid derivative having bulky optical activity, intended for peptide synthesis including a β-amino acid having bulky optical activity.SOLUTION: The present invention provides a method for synthesizing a cyanation product having a bulky tertiary alkylated structure and having optical activity, by reacting an α-haloamide having a bulky tertiary alkylated structure and having optical activity with a cyanohydrin in the presence of a copper catalyst.SELECTED DRAWING: None

The present invention discloses an application of a copper catalyst in the electrocatalytic selective hydrogenation of the cyano group of nitrile organic compounds to prepare primary amines. In this application, the highly selective hydrogenation of the terminal cyano group of nitrile organic compounds to synthesize primary amine organic compounds is realized under an electrochemical system. This method has the characteristics of low cost of the required catalyst, stable performance, mild conditions for hydrogenating to prepare primary amines, simple operation, environmental protection, etc., and has good application prospects.

This invention discloses a novel chiral bipyridine ligand, its synthesis method, and its application. The novel chiral bipyridine ligand is selected from compounds with the following structures: The chiral ligand of this invention has been successfully applied in the copper-catalyzed asymmetric ring-opening / cross-coupling reaction of cyclic diaryl iodine and secondary amine, yielding the product with excellent yield and ee value.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a novel lignin-based copper catalyst and a preparation method and application thereof. The preparation method comprises the following steps: mixing lignin with cyanuric chloride, heating for reaction, and carrying out suction filtration and washing to obtain cyanuric chloride functionalized lignin; mixing the cyanuric chloride functionalized lignin with benzylamine, reacting, and carrying out suction filtration and washing to obtain benzylamine functionalized lignin; and adding the benzylamine functionalized lignin and cuprous iodide into a solvent, reacting, carrying out suction filtration, and washing to obtain the lignin-based copper catalyst. The lignin-based copper catalyst prepared by the method is low in preparation cost, can be recycled, and has the advantages of mild catalytic conditions, high catalytic efficiency and high yield.

Dichloroacetonitrile is an important raw material required for the production of florfenicol, a new Class II veterinary drug in China, and has a promising market prospect. The present invention discloses a method for preparing dichloroacetonitrile, comprising the following steps: using dichloroacetaldehyde as a raw material, in the presence of different nitrogen sources and a copper catalyst, and using air as an oxidant to generate dichloroacetonitrile. The reaction liquid is filtered, extracted, and distilled to obtain a colorless liquid with a purity greater than 99%. Compared with the traditional method of preparing dichloroacetonitrile using phosphorus pentoxide, the present invention has a simple reaction, mild conditions, simple post-processing, and is more environmentally friendly, providing a new approach to the production of dichloroacetonitrile.

The invention relates to the technical field of catalysts, and discloses a copper catalyst, a preparation method and application thereof, and a method for preparing ester and / or ketone compounds through alcohol compound dehydrogenation. The copper catalyst contains a Cu element, a Mn element and an Al element, and on the basis of the total weight of the copper catalyst, the content of the Cu element in the copper catalyst is 32 wt%-60 wt%, the content of the Mn element in the copper catalyst is 3 wt%-16 wt%, and the content of the Al element in the copper catalyst is 10 wt%-32 wt%; the copper catalyst contains a CuO crystal phase and / or a CuAl2O4 spinel phase. The copper catalyst provided by the invention has the advantages of high catalytic activity, high raw material conversion rate and high target product selectivity when being applied to dehydrogenation preparation of ester and / or ketone compounds from alcohol compounds.

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

This invention discloses a low-to-medium temperature cyclohexanol dehydrogenation catalyst for cyclohexanone and its preparation method. The catalyst uses organomontmorillonite as a support, and copper species are loaded onto the support using an impregnation method. The copper ion content is 1%–20% by mass of the catalyst, and 0.1%–2% of an additive is added. After washing, drying, and calcination, the organomontmorillonite-supported copper catalyst is obtained. The catalyst prepared by this invention has high specific surface area, high activity, and stability. Under relatively low reaction conditions and with low copper content, the catalyst still exhibits good cyclohexanol conversion and cyclohexanone selectivity. Furthermore, due to the low reaction temperature, the aggregation of the active components of the catalyst is not significant, resulting in good stability.

This invention relates to the field of organic synthetic chemistry, specifically to a polysubstituted furan compound and its synthetic method, wherein the method comprises... β Using ketone sulfones and olefins as starting materials, polysubstituted furans are synthesized via a [3+2] cycloaddition reaction in the presence of a copper catalyst and an oxidant. This invention employs cuprous bromide as the catalyst and di-tert-butyl peroxide (DTBP) as the oxidant, reacting in dimethyl sulfoxide solvent at 100°C–130°C for 6–24 h. This method offers advantages such as high atom and step economy, broad substrate applicability, good functional group tolerance, excellent position selectivity, and high yield, with a maximum yield reaching 84%. It is suitable for large-scale synthesis and provides a new strategy for the synthesis of furans in medicinal chemistry and materials science.

The present invention discloses a synthetic method for constructing a new C-C bond by the copper-catalyzed cross-coupling reaction of arylsulfonium salts with arylsilanes. The method uses arylsulfonium salts and arylsilanes as reaction raw materials, arylsulfonium salts as electrophilic reagents, and arylsilanes as nucleophilic reagents to synthesize biaryl compounds under the conditions of a catalyst / ligand / base / solvent. Among them, the catalyst is cuprous iodide, and 1,10-Phen and cesium fluoride are used as additives to achieve the synthesis of biaryl compounds at 70 °C. The reaction of the method of the present invention avoids the use of aryl halides and reduces environmental pollution. In addition, the reaction uses arylsulfonium salts as electrophilic reagents, improving the site selectivity of the reaction. The reaction avoids the use of organometallic reagents, avoiding the toxicity and instability of organometallic reagents. The reaction avoids the use of precious metal catalysts and uses inexpensive cuprous iodide as a metal catalyst, reducing the cost of synthesizing biaryl compounds.

The invention belongs to the technical field of high polymer material synthesis and heterogeneous catalysis, and particularly discloses an amino mesoporous silica supported copper catalyst as well as a preparation method and application thereof. The catalyst is prepared by a direct co-condensation method which comprises the following steps: in the presence of a structure-directing agent, copolymerizing a silicon source and amino silane to form a mesoporous silica carrier which has a regular mesoporous structure and is modified by amino in a skeleton; then loading cuprous through a solid-state ion exchange method in an inert atmosphere, and stably endowing highly dispersed cuprous (Cu < + >) with an active center through low-temperature heat treatment; the catalyst can be used for efficiently catalyzing oxidative coupling of phenol, and is particularly suitable for synthesizing polyphenyl ether with controllable number-average molecular weight and terminal functionality, the synthesized product is high in purity and narrow in molecular weight distribution, and the catalyst is particularly suitable for high-performance copper-clad plates, semiconductor packaging and other electronic chemicals.

Described herein is a process for performing amidation of polyolefins including reacting a polyolefin, a copper catalyst, an amide, a ligand and an oxidant. Specifically, polyethylene may be reacting to have a degree of amide incorporation of about 0.01 mol % to about 4.75 mol % based on monomer units.

The application relates to the field of organic matter synthesis, and particularly discloses a method for preparing 2,4-difluorophenol through diazotization and hydrolysis, which comprises the following steps: 2,4-difluorodiazonium salt / sulfuric acid aqueous solution is hydrolyzed under acidic conditions through a catalyst copper sulfate to obtain 2,4-difluorophenol; in the reaction, copper sulfate is used as the catalyst to catalyze the hydrolysis of diazonium salt to obtain the finished product; after the reaction is completed, the catalyst copper sulfate is recovered and applied to the next batch; the process operation is simple and easy to implement, the yield is high, the product quality is high, no waste is generated after the catalyst copper sulfate is applied, and the method is suitable for industrial production.

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to an alpha-carbon chiral phosphine compound and a preparation method thereof. In a protective gas atmosphere, an asymmetric boron protonation reaction is carried out on a dienyl phosphine oxide compound shown in a structure of formula II, pinacol borate, a copper (I) catalyst, a chiral ligand, an organic alkaline compound and a proton additive in a polar organic solvent to obtain an alpha-carbon chiral phosphine compound shown in a structure of formula I; the chiral ligand is a cyclic phosphine ligand (S, S)-Ph-BPE or a cyclic phosphine ligand (R, R)-Ph-BPE. The preparation method provided by the application can synthesize the alpha-carbon chiral phosphine compound shown in the structure of formula I with high yield and excellent enantioselectivity, the synthesis method is simple and low in cost, and the alpha-carbon chiral phosphine compound can be further converted into a new optically active product.

The invention relates to the technical field of impurity removal and recycling of silicon-containing waste residues, and discloses an impurity removal and utilization method of silicon-containing waste residues in a polycrystalline silicon production process, which comprises the following steps: immersing the silicon-containing waste residues in the polycrystalline silicon production process into a leaching solution containing hydrofluoric acid and copper nitrate, adding hydrogen peroxide, and carrying out a metal-assisted chemical etching reaction, obtaining silicon powder attached with copper; and the silicon powder attached with copper is annealed and then put into a cold hydrogenation reaction. According to the method, the purification of the silicon-containing waste residues and the loading of copper can be realized in one step by utilizing a metal-assisted chemical etching method, and a cuprous chloride catalyst does not need to be additionally added in a subsequent cold hydrogenation process. The silicon powder in the silicon-containing waste residue is recycled, the production cost is reduced, the waste of resources is avoided, and the method conforms to the criterion of harmless treatment.

The invention relates to the technical field of catalytic reaction, and discloses a collision catalytic reactor and application thereof. The collision catalytic reactor can adjust the flow velocity of the reaction gas, and the mechanical energy of the reaction gas is utilized to drive the catalyst particles to cyclically collide with the target body. In the process, the size and the structure of catalyst particles are changed, dynamic adjustment of the surface of the catalyst is achieved, then the efficiency and the stability of the catalytic reaction are improved, and a large number of opportunities are created for discovery of new catalytic reactions. The collision catalytic reactor is simple in structure, stable in operation and suitable for gas-solid phase reaction. Compared with a traditional reaction mode in a fixed bed reactor, on the same aluminum oxide supported copper catalyst, the carbon dioxide hydrogenation rate is improved by more than three times, the methanol selectivity is improved by more than two times, and the stability is also remarkably improved.

This application discloses methods of copper-catalyzed bimodal dehydrogenation and lactonization of N-methoxyamides via γ-C-H radical abstraction.