245 results about "Copper catalyzed" patented technology

The invention relates to the field of catalysts, in particular to a preparation method of a green and efficient copper catalyst. Comprising the following steps: (1) mixing basic cupric carbonate, ammonia water and water, adding ammonium salt at the same time, and preparing a copper ammonia solution as a precursor solution at room temperature; (2) mixing the precursor solution with a carrier or a carrier precursor to realize active component loading and catalyst preparation; and (3) filtering, washing, drying and roasting the mixed system in the step (2) to prepare the copper-based catalyst. According to the preparation method of the copper ammonia complexing precursor solution, preparation of the copper ammonia complexing solution at room temperature can be achieved, heating operation in the precursor preparation process is avoided, meanwhile, the nitrogen content of the system and nitrogen emission in the subsequent roasting process can be reduced by preparing the copper-based catalyst through the basic copper carbonate precursor, and efficient and green preparation of the catalyst is achieved.

The invention relates to a green preparation method of fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylaminopyridine, which comprises the following steps: step 1, Ullmann reaction: coupling 3-chloro-2-methyl-5-trifluoromethylpyridine (C1) and N-bromomethyl phthalimide (C2) in the presence of a copper catalyst and potassium tert-butoxide to generate an intermediate (C3); and step 2, hydrolysis reaction: hydrolyzing the intermediate (C3) in the presence of hydrazine sulfate and an alkaline condition to generate the fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylamino pyridine. The method has the advantages of short synthesis steps, easily available raw materials, no use of high-toxicity cyanogen compounds, low catalyst cost, difficult poisoning, recycling, simple post-treatment process, and less waste liquid generation, greatly reduces the production cost, improves the production safety, reduces the waste liquid discharge amount, and accords with the idea of green synthesis.

The invention discloses a novel method for synthesizing 1, 3-diketone organic matters, which comprises the following steps: by taking acyl chloride and silyl enol ether as raw materials, generating acyl free radicals through photo-induced copper catalysis, and carrying out free radical addition reaction on the acyl free radicals and silyl enol ether, thereby efficiently constructing 1, 3-diketone compounds. Compared with strong base, oxidant, high temperature and expensive metal catalyst required by the existing method, the method provided by the invention adopts the cheap and high-yield copper catalyst, so that the production cost is reduced, and the economic benefit is improved. In addition, the method has mild reaction conditions, easily available catalysts and raw materials, utilizes clean and sustainable light energy as driving force, is simple and convenient to operate, and is suitable for large-scale production. The invention provides an economic and environment-friendly innovative way for synthesizing the 1, 3-diketone compound, and has a wide application prospect.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.

The invention discloses a titanium-oxygen cluster cavity confinement monatomic copper catalyst as well as a preparation method and application thereof, and relates to the field of material science and photoelectrocatalysis. The method for preparing the titanium oxide cluster cavity confinement monatomic copper catalyst comprises the following steps: firstly preparing a titanium oxide cluster with a large cavity structure, and then coordinating and anchoring copper ions and water molecules in a cavity by using the assistance of NaBH4 to obtain the titanium oxide cluster cavity confinement monatomic copper catalyst. According to the method, the Ti16 precursor is firstly synthesized, and then Cu is directionally anchored in the cavity through NaBH4-assisted reduction, so that the defect of non-uniform metal distribution caused by a traditional one-pot method is overcome, high yield and good reproducibility of the catalyst are realized, and industrial requirements are met. According to the titanium oxide cluster cavity confinement monatomic copper catalyst Ti16 cluster prepared by the method disclosed by the invention, a rigid cavity formed by an octagonal prism framework can efficiently anchor copper atoms, so that the problem of migration and agglomeration of metal sites in a traditional catalyst is avoided.

The invention discloses a hydrogen-fluorine atom doped graphdiyne material and a preparation method thereof, and relates to the technical field of carbon materials. According to the method, halogenated aromatic hydrocarbon and an alkynyl compound are taken as raw materials, a palladium catalyst and a copper catalyst are taken as a catalytic system, and an acetylenic bond of the alkynyl compound and the halogenated aromatic hydrocarbon are subjected to a Sonogashira coupling reaction to obtain the hydrogen-fluorine-doped graphite alkynyl material. The graphdiyne material provided by the invention has a large pore diameter, multiple active sites and high thermal stability and chemical stability, so that the hydrofluorine-doped graphdiyne material has excellent electrochemical energy storage property, shows reversible capacity of 1155mAh g <-1 > under 0.05 Ag <-1 > when being used as a negative electrode of a lithium ion battery, and can be used as a negative electrode of the lithium ion battery. And the density is almost 3 times that of a commercial graphite negative electrode material (300-350mAh g <-1 >). The application of the graphdiyne material in the field of electrochemical energy storage is obviously promoted.

The present invention discloses a method for preparing an indolinone compound containing a quaternary carbon center. The target compound is obtained by subjecting N-arylacrylamide to an intramolecular tandem oxidative cyclization reaction initiated by the addition of an intramolecular alkyl radical with a tertiary alkane in the presence of a copper catalyst. This novel synthetic route for indolinone compounds containing a quaternary carbon center offers advantages such as high efficiency, relatively mild reaction conditions, a wide range of substrate applicability, and high atom and step economies, and has potential applications in pharmaceutical synthesis.

To provide a method for synthesizing a cyanide that is a precursor to a β-amino acid derivative having bulky optical activity, intended for peptide synthesis including a β-amino acid having bulky optical activity.SOLUTION: The present invention provides a method for synthesizing a cyanation product having a bulky tertiary alkylated structure and having optical activity, by reacting an α-haloamide having a bulky tertiary alkylated structure and having optical activity with a cyanohydrin in the presence of a copper catalyst.SELECTED DRAWING: None

This invention discloses a novel chiral bipyridine ligand, its synthesis method, and its application. The novel chiral bipyridine ligand is selected from compounds with the following structures: The chiral ligand of this invention has been successfully applied in the copper-catalyzed asymmetric ring-opening / cross-coupling reaction of cyclic diaryl iodine and secondary amine, yielding the product with excellent yield and ee value.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a novel lignin-based copper catalyst and a preparation method and application thereof. The preparation method comprises the following steps: mixing lignin with cyanuric chloride, heating for reaction, and carrying out suction filtration and washing to obtain cyanuric chloride functionalized lignin; mixing the cyanuric chloride functionalized lignin with benzylamine, reacting, and carrying out suction filtration and washing to obtain benzylamine functionalized lignin; and adding the benzylamine functionalized lignin and cuprous iodide into a solvent, reacting, carrying out suction filtration, and washing to obtain the lignin-based copper catalyst. The lignin-based copper catalyst prepared by the method is low in preparation cost, can be recycled, and has the advantages of mild catalytic conditions, high catalytic efficiency and high yield.

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

This invention discloses a low-to-medium temperature cyclohexanol dehydrogenation catalyst for cyclohexanone and its preparation method. The catalyst uses organomontmorillonite as a support, and copper species are loaded onto the support using an impregnation method. The copper ion content is 1%–20% by mass of the catalyst, and 0.1%–2% of an additive is added. After washing, drying, and calcination, the organomontmorillonite-supported copper catalyst is obtained. The catalyst prepared by this invention has high specific surface area, high activity, and stability. Under relatively low reaction conditions and with low copper content, the catalyst still exhibits good cyclohexanol conversion and cyclohexanone selectivity. Furthermore, due to the low reaction temperature, the aggregation of the active components of the catalyst is not significant, resulting in good stability.

This invention relates to the field of organic synthetic chemistry, specifically to a polysubstituted furan compound and its synthetic method, wherein the method comprises... β Using ketone sulfones and olefins as starting materials, polysubstituted furans are synthesized via a [3+2] cycloaddition reaction in the presence of a copper catalyst and an oxidant. This invention employs cuprous bromide as the catalyst and di-tert-butyl peroxide (DTBP) as the oxidant, reacting in dimethyl sulfoxide solvent at 100°C–130°C for 6–24 h. This method offers advantages such as high atom and step economy, broad substrate applicability, good functional group tolerance, excellent position selectivity, and high yield, with a maximum yield reaching 84%. It is suitable for large-scale synthesis and provides a new strategy for the synthesis of furans in medicinal chemistry and materials science.

The invention belongs to the technical field of high polymer material synthesis and heterogeneous catalysis, and particularly discloses an amino mesoporous silica supported copper catalyst as well as a preparation method and application thereof. The catalyst is prepared by a direct co-condensation method which comprises the following steps: in the presence of a structure-directing agent, copolymerizing a silicon source and amino silane to form a mesoporous silica carrier which has a regular mesoporous structure and is modified by amino in a skeleton; then loading cuprous through a solid-state ion exchange method in an inert atmosphere, and stably endowing highly dispersed cuprous (Cu < + >) with an active center through low-temperature heat treatment; the catalyst can be used for efficiently catalyzing oxidative coupling of phenol, and is particularly suitable for synthesizing polyphenyl ether with controllable number-average molecular weight and terminal functionality, the synthesized product is high in purity and narrow in molecular weight distribution, and the catalyst is particularly suitable for high-performance copper-clad plates, semiconductor packaging and other electronic chemicals.

The application relates to the field of organic matter synthesis, and particularly discloses a method for preparing 2,4-difluorophenol through diazotization and hydrolysis, which comprises the following steps: 2,4-difluorodiazonium salt / sulfuric acid aqueous solution is hydrolyzed under acidic conditions through a catalyst copper sulfate to obtain 2,4-difluorophenol; in the reaction, copper sulfate is used as the catalyst to catalyze the hydrolysis of diazonium salt to obtain the finished product; after the reaction is completed, the catalyst copper sulfate is recovered and applied to the next batch; the process operation is simple and easy to implement, the yield is high, the product quality is high, no waste is generated after the catalyst copper sulfate is applied, and the method is suitable for industrial production.

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to an alpha-carbon chiral phosphine compound and a preparation method thereof. In a protective gas atmosphere, an asymmetric boron protonation reaction is carried out on a dienyl phosphine oxide compound shown in a structure of formula II, pinacol borate, a copper (I) catalyst, a chiral ligand, an organic alkaline compound and a proton additive in a polar organic solvent to obtain an alpha-carbon chiral phosphine compound shown in a structure of formula I; the chiral ligand is a cyclic phosphine ligand (S, S)-Ph-BPE or a cyclic phosphine ligand (R, R)-Ph-BPE. The preparation method provided by the application can synthesize the alpha-carbon chiral phosphine compound shown in the structure of formula I with high yield and excellent enantioselectivity, the synthesis method is simple and low in cost, and the alpha-carbon chiral phosphine compound can be further converted into a new optically active product.

The invention discloses a synthesis method of a silicon-substituted benzo-bicyclo [3.1. 1] heptane compound, which comprises the following steps: under the action of a copper catalyst, alkali and a silicon reagent, putting o-alkynyl phenyl cyclobutanone in a solvent for reaction, and carrying out post-treatment to obtain the silicon-substituted benzo-bicyclo [3.1. 1] heptane compound, the silicon source is (dimethylphenylsilyl) boronic acid pinacol ester. The silicon-substituted benzo-bicyclo [3.1. 1] heptane compound is prepared by combining a cheap metal copper catalyst with a silicon reagent. The reaction system is good in selectivity and mild in condition, the highest yield can reach 68%, and the method has wide application prospects.

The invention discloses a method for preparing isopentenyl indole alkaloid Debromolustramine B. The isopentenyl indole alkaloid Debromolustramine B belongs to the technical field of organic synthesis, an o-bromo aniline aldehyde compound is used as an initial raw material, and on the basis of novel chiral p-toluene sulfinyl guidance, cheap copper catalysis amido alpha-position arylation and 3, 3-dimethyl allyl bromide cyclization reaction, the isopentenyl indole alkaloid Debromolustramine B is synthesized, and the isopentenyl indole alkaloid Debromolustramine B is obtained. According to the present invention, the key aryl quaternary carbon chiral center in the isopentenyl indole alkaloid Debomolustramine B is constructed, and the isopentenyl indole alkaloid Debomolustramine B with the butyrylcholine esterase inhibition activity is prepared through the subsequent series of chemical conversion, such that the material basis is provided for the further research of the natural product Debomolustramine B and the analogue thereof. The method has the advantages that the reaction conditions are mild, the cheap metal copper is used as the catalyst, the synthesis route is short, the energy consumption is low, the environmental protection is facilitated, and the large-scale chiral preparation of the isopentenyl indole alkaloid Debromofloutramine B is facilitated; the method also has the characteristics of relatively good atom economy and high product yield.

The invention belongs to the field of fine chemical engineering, and discloses an electrochemical method for preparing enol through hydrogenation of alkynol compounds. According to the method, 2-methyl-3-butyne-2-alcohol is selectively converted into 2-methyl-3-butene-2-alcohol through an electrochemical method by taking palladium and copper-containing metals as electrode materials and taking a catalyst PdCu / CC, and the selectivity is greater than 96% and is far better than that of a single metal palladium and copper catalyst. The electrochemical method provided by the invention has the advantages of environment-friendly process, no need of external hydrogen input, reaction at normal temperature and normal pressure, mild conditions, simple catalyst preparation process, recyclability and cost saving, conforms to the development direction of green chemical synthesis, and has good industrial application prospects.

The application relates to a copper catalyst and a preparation method and application thereof, and relates to a Cu-ALPO4-5 molecular sieve prepared from CuNO3.3H2O, Al2O3, P2O5, Et3N, HF, H2O and the like as raw materials in a proper proportion at a certain temperature, which is used to catalyze the oxidation reaction of isoneral, and the catalytic effect is tested. Compared with the prior art, the copper catalyst prepared by the method has the advantages of simple preparation method, and the catalyst has good conversion rate and selectivity in the oxidation reaction of isoneral.

The invention discloses a copper molybdate catalyst, a preparation method, application and a method for producing 4-propyl phenol. A preparation method of a copper molybdate catalyst for catalyzing demethoxylation of 4-propyl guaiacol comprises the following steps: mixing water-soluble molybdate, water-soluble copper salt and water to obtain a metal aqueous solution; and concentrating, drying and calcining the metal aqueous solution to obtain the copper molybdate catalyst. The preparation method is simpler to operate and more environmentally friendly, the prepared copper molybdate catalyst can be used for catalyzing 4-propyl guaiacol to remove methoxy so as to produce 4-propyl phenol, and the catalytic performance and stability are excellent.

This application relates to the field of biomedical materials and discloses a bio-based functional material that promotes blood circulation and its preparation method. The material is in hydrogel form and is prepared from an active precursor solution, a hydrogel matrix solution, and a functional modifier. The active precursor solution is assembled using a eutectic solvent-mediated process, which breaks the hydrogen bonds within the lignin molecule, causing its conformation to unfold, and constructs coordination catalytic centers with copper and chloride ions. The hydrogel matrix solution is mainly composed of polyvinyl alcohol and water. The preparation method includes high-temperature pre-assembly of the precursor, two-phase mixing, reduction regulation, and freeze-thaw cycle molding. This invention utilizes the microenvironmental regulation effect of the eutectic solvent to lower the electron transfer barrier of copper ions and achieves stable anchoring of copper ions using the lignin framework, solving the problems of easy loss and deactivation of copper catalysts. It features high catalytic efficiency, good stability, and suitable mechanical strength, and can efficiently catalyze the release of nitric oxide from endogenous donors.

This invention discloses a copper catalyst, its preparation method, and its applications. Specifically, this invention provides a copper catalyst prepared by the following method: mixing copper salt, coffee grounds, and a solvent, followed by centrifugation and calcination to obtain the copper catalyst. This invention uses inexpensive household waste, coffee grounds, to support copper in the preparation of a heterogeneous copper catalyst. The preparation is convenient, simple, low-cost, and environmentally friendly. Furthermore, the catalyst exhibits excellent performance and is applicable to a wide range of compounds.

According to the 3, 6-dihydro-1, 2-oxazine compound and the synthesis method thereof, 1, 4, 2-dioxazole-5-ketone and 1, 3-conjugated diene are used as raw materials, commercially available cuprous thiocyanate is used as a catalyst, no additional oxidizing agent needs to be added in the reaction process, and 1, 4, 2-dioxazole-5-ketone, 1, 3-conjugated diene and 1, 4, 2-dioxazole-5-ketone are used as raw materials. 2, 2-dioxazole-5-ketone and a copper catalyst form a metal nitrogen-based intermediate which can be used as a self-oxidant to promote the reaction, so that the problems of poor substrate adaptability, low reaction activity, more byproducts and the like of a traditional cyclization method are solved; compared with harmful by-products (such as sulfur / nitrogen-containing compounds or heavy metal residues) generated by a traditional process, the environment friendliness of the method is remarkably improved, and meanwhile, the waste treatment cost is reduced, so that the comprehensive benefits of industrial production are effectively improved.

The invention discloses C2-quaternary carbon amino sugar as well as a preparation method and application thereof. According to the preparation method, C2-position functionalized glyene is taken as a raw material, di-tert-butyldiaziridone is taken as a nitrogen source, and a double amination reaction of unsaturated bonds of sugar rings is realized by utilizing a copper-catalyzed nitrogen-nitrogen bond activation strategy, so that the C2-quaternary carbon amino sugar compound is constructed. In-vitro antifungal activity research results show that the C2-quaternary carbon amino sugar has certain inhibitory activity on tested fungi, and the compounds I-2 and I-3 show good broad-spectrum antibacterial biological activity and can be used as an agricultural bactericide. The C2-quaternary carbon amino sugar developed by the invention has the remarkable characteristics of simple and efficient synthesis method, cheap and easily available raw materials, mild reaction conditions and the like, and has a good application prospect.

The purpose of the present invention is to provide a method for producing a hydroxybiotin derivative and a vinylbiotin derivative with which it is possible to carry out, in a smooth and highly efficient manner, a coupling reaction between a thiolactone derivative and a zinc reagent containing a halogen atom other than an iodine atom by using an inexpensive metal catalyst. The present invention provides a method for producing a hydroxybiotin derivative, the method including a step for bringing a thiolactone derivative represented by formula (1) into contact with a zinc reagent represented by formula (2) in the presence of a copper catalyst and an amine compound, thereby obtaining a hydroxybiotin derivative represented by formula (3).

The invention discloses a preparation method and application of a monatomic copper feed additive, and the preparation method comprises the following steps: step 1, preparing a mixed solution A, putting melamine and copper nitrate into a sufficient dimethyl sulfoxide solution, and uniformly stirring to obtain a light green solution; step 2, preparing a mixed solution B, putting cyanuric acid into a sufficient dimethyl sulfoxide solution, and uniformly stirring to obtain a clear transparent solution; 3, mixing the mixed solution A and the mixed solution B, and reacting to obtain a precipitate; 4, filtering, washing and drying the precipitate to obtain a precursor; 5, under the inert atmosphere, the precursor is subjected to heat treatment, and the monatomic copper catalyst is obtained; the prepared monatomic copper feed additive is used in broiler feed. The monatomic copper feed additive is prepared, belongs to nano-enzyme, and has remarkable effects of resisting escherichia coli and reducing ammonia in chicken manure when being used for broiler chicken feeding.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method for constructing a beta-amino-organic selenium compound through copper catalysis. The structural formula of the compound is shown as a general formula X, and the compound with the general formula X is prepared from aryl olefin, aryl selenide, a copper catalyst, an oxidizing agent and a solvent through a one-pot method. Research finds that under the action of an oxidizing agent, aryl selenide is oxidized into selenium positive ions by the oxidizing agent, then aryl olefin is attacked to form a carbocation intermediate, then nitrile nucleophilic attacks carbocation under the catalysis of copper, and then the target beta-amino-organic selenium compound is formed. The synthesis method is low in cost, green, efficient and wide in substrate application range.

A copper catalyst for the electrochemical conversion of carbon dioxide or carbon monoxide to a C2 + product. According to the present invention, there is provided a catalyst for the electrochemical conversion of carbon dioxide or carbon monoxide to a C2 + product. The catalyst comprises copper and a metal (M); wherein the molar ratio of Cu to M in the catalyst is 100: 0.1 to 100: 10. The catalyst comprises a core and a modified surface layer, wherein the modified surface layer comprises a higher concentration of metal (M) than the core. The catalyst is particularly useful in a gas diffusion electrode and a catalyst coating film of an electrolytic cell.