515 results about "Copper catalyzed" patented technology

The invention belongs to the technical field of electrolysis CO2 reduction, and discloses an electrocatalytic reduction system for preparing ethylene through electrochemical reduction of carbon dioxide and application of the electrocatalytic reduction system. The electrocatalytic reduction system comprises a cathode, an anode and an electrolyte, wherein the cathode is prepared by uniformly mixing and dispersing a copper-based catalyst, liquid micromolecular alcohols and a Nafion solution to obtain slurry and then spraying the obtained slurry onto carbon paper; the electrolyte is KOH electrolyte containing a sucrose additive. The copper catalytic reaction interface is regulated and controlled through sucrose molecules, the enrichment concentration of reactants near the reaction interface and key intermediates generated by catalyzing C2H4 is remarkably improved, generation of C2H4 through subsequent C-C coupling reaction is promoted, the yield of C2H4 is remarkably improved, meanwhile, the raw material cost is low, and wide application prospects are achieved.

The invention relates to the field of catalysts, in particular to a preparation method of a green and efficient copper catalyst. Comprising the following steps: (1) mixing basic cupric carbonate, ammonia water and water, adding ammonium salt at the same time, and preparing a copper ammonia solution as a precursor solution at room temperature; (2) mixing the precursor solution with a carrier or a carrier precursor to realize active component loading and catalyst preparation; and (3) filtering, washing, drying and roasting the mixed system in the step (2) to prepare the copper-based catalyst. According to the preparation method of the copper ammonia complexing precursor solution, preparation of the copper ammonia complexing solution at room temperature can be achieved, heating operation in the precursor preparation process is avoided, meanwhile, the nitrogen content of the system and nitrogen emission in the subsequent roasting process can be reduced by preparing the copper-based catalyst through the basic copper carbonate precursor, and efficient and green preparation of the catalyst is achieved.

The invention discloses a graphite diacetylene / copper oxide composite material cocatalyst and a co-production preparation process and application thereof. Graphite diyne has a two-dimensional layered structure and is composed of sp and sp hybridized carbon atoms, a periodically distributed structure is formed, and excellent electron transmission performance and pore structure are shown. An existing graphite diacetylene synthesis method is complex and high in cost, large-scale application of the graphite diacetylene in the industrial field is seriously restricted, the potential value of a copper catalyst cannot be fully exerted, and resource waste is caused. According to the invention, through a simple and efficient co-production process, co-production of graphite diyne and copper oxide nanoparticles is realized for the first time, and the graphite diyne / copper oxide composite material is successfully prepared. The novel composite material can be used as a cocatalyst to effectively improve photocatalytic hydrogen production, and the hydrogen production performance can be comparable with that of noble metal photocatalysts such as Pt. The problems of tedious steps, high energy consumption, low yield and the like in a traditional preparation method are solved, and the preparation method has important application value in the field of high-performance photocatalysis.

The invention discloses a sgRNA-based method for modifying and regulating gene editing, which comprises the following steps: carrying out POC acylation modification on a 2 '-OH site of sgRNA to introduce an alkynyl marker to obtain sgRNA with alkynyl; the sgRNA with alkynyl and azide are subjected to copper-catalyzed azide-alkynyl cycloaddition reaction under the action of a copper catalytic reagent to form a stable chemical cross-linked structure, so that the activity of the sgRNA is quickly closed and adjusted. According to the method, alkynyl is introduced to sgRNA and is subjected to a CuAAC reaction with multi-azide to form stable crosslinking, so that the activity of the CRISPR-Cas9 system is accurately controlled. The innovative method not only can effectively control the gene editing activity on the basis of not destroying the original structure and function of RNA, but also can significantly improve the target specificity of the CRISPR system and reduce the risk of genome damage caused by non-specific cleavage.

The invention discloses an osthole compound, a metal complex and a preparation method and application of the osthole compound, the osthole compound (OST-Alkyne) has remarkable anti-tumor biological activity, osthole (OST) and a cyclometalated iridium precursor are further connected through a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, higher anti-tumor activity is shown, and the osthole compound has a good application prospect. Mitochondria is targeted, and tumor is killed by reducing mitochondrial membrane potential and inducing cell autophagy and necrotic apoptosis; according to the invention, natural products are combined with metals, so that not only are good selectivity and anti-proliferation ability to brain glioma cells realized, but also toxic and side effects to normal cells are overcome, a new design idea is provided for novel metal drugs to treat brain glioma, and the application prospect is wide.

The invention belongs to the technical field of thermosetting polyphenyl ether, and particularly relates to thermosetting polyphenyl ether as well as a preparation method and application thereof. The preparation method of the thermosetting polyphenyl ether comprises the following steps: mixing a copper catalyst, an amine compound, an organic acid compound, an organic acid ester compound, monohydric phenol, dihydric phenol and a solvent, reacting, and removing the copper catalyst to prepare a dihydroxy-terminated polyphenyl ether solution; and mixing an end-capping catalyst, an alkenylation reagent and the dihydroxy-terminated polyphenyl ether solution, reacting, separating and purifying to obtain the thermosetting polyphenyl ether. The organic acid compound and the organic acid ester compound are simultaneously added in the oxidative copolymerization process, the organic acid compound and the organic acid ester compound have a synergistic effect and are combined with other components, so that the chromaticity of the thermosetting polyphenyl ether can be obviously reduced, and the platinum-cobalt chromaticity value of a 50wt% butanone solution can be as low as 14-16; meanwhile, the intrinsic viscosity and the molecular structure of the thermosetting polyphenyl ether are not obviously changed.

The invention relates to a green preparation method of fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylaminopyridine, which comprises the following steps: step 1, Ullmann reaction: coupling 3-chloro-2-methyl-5-trifluoromethylpyridine (C1) and N-bromomethyl phthalimide (C2) in the presence of a copper catalyst and potassium tert-butoxide to generate an intermediate (C3); and step 2, hydrolysis reaction: hydrolyzing the intermediate (C3) in the presence of hydrazine sulfate and an alkaline condition to generate the fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylamino pyridine. The method has the advantages of short synthesis steps, easily available raw materials, no use of high-toxicity cyanogen compounds, low catalyst cost, difficult poisoning, recycling, simple post-treatment process, and less waste liquid generation, greatly reduces the production cost, improves the production safety, reduces the waste liquid discharge amount, and accords with the idea of green synthesis.

The invention discloses a doped zirconium dioxide / copper oxide composite catalyst and a preparation method and application thereof.The preparation method comprises the steps that sodium hydroxide, basic zirconium carbonate and transition metal nitrate are added into deionized water to obtain a mixed solution, the mixed solution is subjected to a hydrothermal reaction and then diluted to obtain a reaction solution, H2O2 is added into the reaction solution, and the doped zirconium dioxide / copper oxide composite catalyst is obtained. Centrifuging and drying to obtain a reaction product; adding water into the reaction product to form a turbid liquid, adding a copper nitrate trihydrate solution into the turbid liquid, adding a sodium carbonate aqueous solution to adjust the pH value to 9-10, and then stirring, standing, carrying out suction filtration, drying and roasting to obtain the transition metal doped zirconium dioxide / copper oxide catalyst. The transition metal doped zirconium dioxide / copper oxide catalyst prepared by the preparation method has relatively high catalytic activity and relatively high stability in an acidic electrolyte.

The invention relates to the technical field of functional materials, in particular to a metal-DNA aptamer self-assembled nano material as well as a preparation method and application thereof. The metal-DNA aptamer self-assembled nano material comprises two DNA aptamers, a copper source and ascorbic acid, wherein the two DNA aptamers are used for modifying an azide group and an alkynyl group respectively; and copper is coordinated with a five-membered ring formed by a reaction through a copper-catalyzed azide-alkynyl cycloaddition reaction, so that the Cu-DNA aptamer self-assembled nano material is obtained. The problem that an existing metal-DNA self-assembly nanometer material cannot stably exist in a physiological environment is solved, and meanwhile, the application of the metal-DNA self-assembly nanometer material in chemokinetic tumor treatment is achieved by precisely recognizing tumor cells in a targeted mode.

The invention discloses a recyclable porous copper / cuprous oxide filamentous catalytic material and also discloses a preparation method of the catalytic material, and the preparation method comprises the following steps: taking a copper wire and pre-treating the copper wire to remove surface oxides; performing zinc electrodeposition treatment on the copper wire to obtain a galvanized copper wire; carrying out solution treatment on the galvanized copper wire to obtain a porous copper precursor; then, the porous copper precursor is subjected to corrosion treatment, zinc in a plating layer is removed, and a porous copper catalyst carrier is obtained; and putting the porous copper catalyst carrier into a tubular furnace for high-temperature oxidation to obtain the Cu / Cu2O filamentous catalytic material. The catalytic material provided by the invention has the characteristics of recoverability and good catalytic performance. According to the method, cuprous oxide is generated by adopting a one-step high-temperature thermal oxidation method, and regulation and control parameters are few and easy to control in the process.

The invention discloses a novel method for synthesizing 1, 3-diketone organic matters, which comprises the following steps: by taking acyl chloride and silyl enol ether as raw materials, generating acyl free radicals through photo-induced copper catalysis, and carrying out free radical addition reaction on the acyl free radicals and silyl enol ether, thereby efficiently constructing 1, 3-diketone compounds. Compared with strong base, oxidant, high temperature and expensive metal catalyst required by the existing method, the method provided by the invention adopts the cheap and high-yield copper catalyst, so that the production cost is reduced, and the economic benefit is improved. In addition, the method has mild reaction conditions, easily available catalysts and raw materials, utilizes clean and sustainable light energy as driving force, is simple and convenient to operate, and is suitable for large-scale production. The invention provides an economic and environment-friendly innovative way for synthesizing the 1, 3-diketone compound, and has a wide application prospect.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.

The invention discloses a preparation method of a sacubitril intermediate, which comprises the following steps: taking N-tert-butoxycarbonyl-L-serine ester as an initial raw material, reacting with sulfonyl chloride under the catalysis of an alkaline substance to obtain N-(tert-butoxycarbonyl)-O-sulfonyl-L-serine ester, activating hydroxyl in the compound by sulfonate, and reacting with sodium hydroxide to obtain the sacubitril intermediate. The preparation method comprises the following steps: reacting (R)-3-([1, 1 '-biphenyl]-4-yl)-2-(tert-butoxycarbonyl) amino) propionate with a Grignard reagent under the catalysis of copper to generate (R)-3-([1, 1'-biphenyl]-4-yl)-2-(tert-butoxycarbonyl) amino) propionate, and finally reducing ester groups into hydroxyl groups under the action of a catalyst and a reducing agent to generate (R)-tert-butyl (1-([1, 1 '-biphenyl]-4-yl)-3-hydroxypropane-2-yl) carbamate. The preparation method has the advantages of simple preparation process route, cheap and easily available raw materials, short synthesis route, mild reaction conditions, simplicity and convenience in operation and high yield, and has better application value and economic benefit.

The invention relates to a process for electrolyzing carbon oxides selected from carbon monoxide and / or carbon dioxide into ethylene by means of an electrolyser comprising a cathode catalyst being a dendritic copper oxide catalyst or a dendritic copper catalyst.

The invention relates to application of an amide ligand and a copper catalyst in preparation of an amino indazole piperidine compound. The indazole piperidine compound is prepared by reacting a halogen-substituted indazole piperidine compound with an ammonia reagent, the reaction is carried out under the action of an amide ligand and a catalyst, the amide ligand is # imgabs0, the structural formula of the amide ligand is # imgabs1 # or L-hydroxyproline, and the catalyst is a cuprous compound.

The invention discloses a titanium-oxygen cluster cavity confinement monatomic copper catalyst as well as a preparation method and application thereof, and relates to the field of material science and photoelectrocatalysis. The method for preparing the titanium oxide cluster cavity confinement monatomic copper catalyst comprises the following steps: firstly preparing a titanium oxide cluster with a large cavity structure, and then coordinating and anchoring copper ions and water molecules in a cavity by using the assistance of NaBH4 to obtain the titanium oxide cluster cavity confinement monatomic copper catalyst. According to the method, the Ti16 precursor is firstly synthesized, and then Cu is directionally anchored in the cavity through NaBH4-assisted reduction, so that the defect of non-uniform metal distribution caused by a traditional one-pot method is overcome, high yield and good reproducibility of the catalyst are realized, and industrial requirements are met. According to the titanium oxide cluster cavity confinement monatomic copper catalyst Ti16 cluster prepared by the method disclosed by the invention, a rigid cavity formed by an octagonal prism framework can efficiently anchor copper atoms, so that the problem of migration and agglomeration of metal sites in a traditional catalyst is avoided.

The invention discloses a hydrogen-fluorine atom doped graphdiyne material and a preparation method thereof, and relates to the technical field of carbon materials. According to the method, halogenated aromatic hydrocarbon and an alkynyl compound are taken as raw materials, a palladium catalyst and a copper catalyst are taken as a catalytic system, and an acetylenic bond of the alkynyl compound and the halogenated aromatic hydrocarbon are subjected to a Sonogashira coupling reaction to obtain the hydrogen-fluorine-doped graphite alkynyl material. The graphdiyne material provided by the invention has a large pore diameter, multiple active sites and high thermal stability and chemical stability, so that the hydrofluorine-doped graphdiyne material has excellent electrochemical energy storage property, shows reversible capacity of 1155mAh g <-1 > under 0.05 Ag <-1 > when being used as a negative electrode of a lithium ion battery, and can be used as a negative electrode of the lithium ion battery. And the density is almost 3 times that of a commercial graphite negative electrode material (300-350mAh g <-1 >). The application of the graphdiyne material in the field of electrochemical energy storage is obviously promoted.

The invention discloses an oxyhalide atom cluster modified copper catalyst for electrochemical carbon dioxide reduction as well as a preparation method and application of the oxyhalide atom cluster modified copper catalyst, and aims to solve the problems of low activity, poor product selectivity and insufficient stability caused by catalyst reconstruction of a copper-based catalyst. According to the oxyhalide atom cluster modified copper-based catalyst, an oxyhalide atom cluster BiOX or MOCl is deposited on the surface of a metal active center copper-based material, and then negative voltage is applied in a CO2 gas atmosphere for reduction treatment, so that the oxyhalide atom cluster modified copper catalyst is formed. The general chemical formula of the oxyhalide atom cluster modified copper catalyst is BiOX / Cu or MOCl / Cu. The prepared oxyhalide cluster modified copper nano-catalyst has outstanding activity, selectivity and stability, has good multi-carbon Faraday efficiency in the electrochemical carbon dioxide reduction process, and has long-time stability, and FEC < 2 + > is larger than 75%.

The invention discloses a spinel supported copper catalyst, a preparation method and application of the spinel supported copper catalyst in hydrogen production by methanol steam reforming, the molecular formula of the spinel supported copper catalyst is Cu / ZnB2O4, and B is Cr, Al and Ga. The preparation method comprises the following steps: preparing a spinel carrier by adopting a coprecipitation method, washing, filtering, drying and roasting by taking a 25wt% ammonia water solution as a precipitator to obtain ZnB2O4 spinel, and loading Cu by adopting an impregnation method to prepare the Cu / ZnB2O4 catalyst. The raw material cost is low, and the equipment requirement is low; the preparation process is simple and feasible, and the reaction process is easy to control; the composite material can be applied to a methanol steam reforming hydrogen production reaction for the first time, shows excellent reaction performance and thermal stability, basically does not generate CO, has the CO concentration far lower than 10ppm, and can be applied to a vehicle-mounted power generation system in which methanol steam reforming hydrogen production and proton exchange membrane fuel cells are combined.

The present invention discloses a method for preparing an indolinone compound containing a quaternary carbon center. The target compound is obtained by subjecting N-arylacrylamide to an intramolecular tandem oxidative cyclization reaction initiated by the addition of an intramolecular alkyl radical with a tertiary alkane in the presence of a copper catalyst. This novel synthetic route for indolinone compounds containing a quaternary carbon center offers advantages such as high efficiency, relatively mild reaction conditions, a wide range of substrate applicability, and high atom and step economies, and has potential applications in pharmaceutical synthesis.

To provide a method for synthesizing a cyanide that is a precursor to a β-amino acid derivative having bulky optical activity, intended for peptide synthesis including a β-amino acid having bulky optical activity.SOLUTION: The present invention provides a method for synthesizing a cyanation product having a bulky tertiary alkylated structure and having optical activity, by reacting an α-haloamide having a bulky tertiary alkylated structure and having optical activity with a cyanohydrin in the presence of a copper catalyst.SELECTED DRAWING: None

The present invention discloses an application of a copper catalyst in the electrocatalytic selective hydrogenation of the cyano group of nitrile organic compounds to prepare primary amines. In this application, the highly selective hydrogenation of the terminal cyano group of nitrile organic compounds to synthesize primary amine organic compounds is realized under an electrochemical system. This method has the characteristics of low cost of the required catalyst, stable performance, mild conditions for hydrogenating to prepare primary amines, simple operation, environmental protection, etc., and has good application prospects.

This invention discloses a novel chiral bipyridine ligand, its synthesis method, and its application. The novel chiral bipyridine ligand is selected from compounds with the following structures: The chiral ligand of this invention has been successfully applied in the copper-catalyzed asymmetric ring-opening / cross-coupling reaction of cyclic diaryl iodine and secondary amine, yielding the product with excellent yield and ee value.

The application discloses a nickel-doped copper phosphide catalyst for detecting hydrogen sulfide gas, a self-powered gas sensor and application, and belongs to the technical field of gas detection. The self-powered gas sensor comprises a zinc negative electrode, a solid-state electrolyte and an air positive electrode; the air positive electrode comprises a conductive substrate and a nickel-doped copper phosphide catalyst loaded on the conductive substrate; the nickel-doped copper phosphide catalyst comprises Cu3P and Ni doped in the Cu3P crystal lattice at a molar doping ratio of 5%; a copper source and a nickel source are dissolved in deionized water, a phosphorus source is added and stirred, a hydrothermal reaction is carried out, and the product is collected, washed and dried to obtain the nickel-doped copper phosphide catalyst. The application utilizes the excellent oxygen reduction catalytic capacity of Cu3P, uses the same as a zinc-air battery positive electrode catalytic material, enables H2S to form a Cu-S bond after adsorption and occupy oxygen reduction active sites, thus causing the output voltage of the battery to change, and realizes H2S detection without an external power supply.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a novel lignin-based copper catalyst and a preparation method and application thereof. The preparation method comprises the following steps: mixing lignin with cyanuric chloride, heating for reaction, and carrying out suction filtration and washing to obtain cyanuric chloride functionalized lignin; mixing the cyanuric chloride functionalized lignin with benzylamine, reacting, and carrying out suction filtration and washing to obtain benzylamine functionalized lignin; and adding the benzylamine functionalized lignin and cuprous iodide into a solvent, reacting, carrying out suction filtration, and washing to obtain the lignin-based copper catalyst. The lignin-based copper catalyst prepared by the method is low in preparation cost, can be recycled, and has the advantages of mild catalytic conditions, high catalytic efficiency and high yield.

Dichloroacetonitrile is an important raw material required for the production of florfenicol, a new Class II veterinary drug in China, and has a promising market prospect. The present invention discloses a method for preparing dichloroacetonitrile, comprising the following steps: using dichloroacetaldehyde as a raw material, in the presence of different nitrogen sources and a copper catalyst, and using air as an oxidant to generate dichloroacetonitrile. The reaction liquid is filtered, extracted, and distilled to obtain a colorless liquid with a purity greater than 99%. Compared with the traditional method of preparing dichloroacetonitrile using phosphorus pentoxide, the present invention has a simple reaction, mild conditions, simple post-processing, and is more environmentally friendly, providing a new approach to the production of dichloroacetonitrile.

The invention relates to the technical field of catalysts, and discloses a copper catalyst, a preparation method and application thereof, and a method for preparing ester and / or ketone compounds through alcohol compound dehydrogenation. The copper catalyst contains a Cu element, a Mn element and an Al element, and on the basis of the total weight of the copper catalyst, the content of the Cu element in the copper catalyst is 32 wt%-60 wt%, the content of the Mn element in the copper catalyst is 3 wt%-16 wt%, and the content of the Al element in the copper catalyst is 10 wt%-32 wt%; the copper catalyst contains a CuO crystal phase and / or a CuAl2O4 spinel phase. The copper catalyst provided by the invention has the advantages of high catalytic activity, high raw material conversion rate and high target product selectivity when being applied to dehydrogenation preparation of ester and / or ketone compounds from alcohol compounds.

Novel compounds including trimeric copper catalysts and intermediates for making such compounds are presented along with methods for preparing and using those compounds.

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

The invention discloses a method for preparing a spirooxindole alkaloid Coerulescine natural product, which comprises the following steps: by taking an o-iodo aniline compound with a chiral sulfinyl prothetic group as a raw material, carrying out coordination induction on chiral sulfinyl as a prothetic group and metal copper, catalyzing a cyclization reaction of amide a-site arylation tandem methyl chloroformate by cuprous iodide, and carrying out condensation reaction on the chiral sulfinyl prothetic group and metal copper to obtain the spirooxindole alkaloid Coerulescine natural product, thereby obtaining the spirooxindole alkaloid Coerulescine natural product. A key aryl quaternary carbon center of a spirooxindole alkaloid Coerulescine natural product is constructed through a cascade reaction catalyzed by one-step cheap metal cuprous iodide, and then the spirooxindole alkaloid Coerulescine natural product is prepared through subsequent chemical conversion. The preparation method provided by the invention is mild in reaction condition and low in energy consumption, cheap metal cuprous iodide is adopted as a catalyst, a tandem cyclization reaction catalyzed by the cheap metal copper in the method is adopted as a key step, and an efficient and universal strategy is developed to synthesize the spirooxindole alkaloid Coerulescine natural product and analogues thereof.