Injected face filler compound gel for cosmetic plastic surgery and preparation method thereof
A filler and injection-type technology, which is applied in the field of injection-type facial filler composition gel for cosmetic plastic surgery and its preparation, can solve problems such as inability to fill, increased extrusion force, and short residence time of hyaluronic acid. Achieve the effect of easy clinical injection and improved durability
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[0053] Example 1 Preparation of a single gel composition (HP) with 1%, 2%, 4% hyaluronic acid and 30% hydroxyapatite microparticles (comparative gel).
[0054] An HP gel composition with a sodium hyaluronate concentration of 1% was prepared.
[0055] Add 1g of HA to 100.9g of solution A under slow stirring, fully wet and swell, and let it stand for 6 hours to obtain a clear and transparent solution or gel. Subsequently, 43.67g of hydroxyapatite is added to grind or stir for 10 minutes to make it mixed into a uniform phase.
[0056] Weigh the formula HA, hydroxyapatite and solution A according to the formula in Example 1 of Table 1, and the preparation method is the same as the preparation method of the HP gel composition of 1% sodium hyaluronate.
[0057] Table 1: The formula composition of Examples 1, 2, 3
[0058]
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[0059] Example 2 Preparation of a single gel composition (MP) with 1%, 3%, 5% methylcellulose (MC) and 30% hydroxyapatite (CaHAP) microparticles (comparative gel).
[0060] The specific formula is shown in Example 2 of Table 1. The preparation method is the same as that of the HP gel composition of 1% sodium hyaluronate in Example 1. Sodium hyaluronate is replaced by sodium methylcellulose in this example. can.
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[0061] Example 3 Preparation of a single gel composition (CP) with 2%, 4%, 6% carboxymethylcellulose sodium (CMC-Na) and hydroxyapatite (CaHAP) microparticles (comparative gel)
[0062] The specific formula is shown in Example 3 in Table 1. The preparation method is the same as the preparation method of the HP gel composition of 1% sodium hyaluronate in Example 1. Sodium hyaluronate can be replaced by the methyl cellulose in this example. .
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