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A kind of composite membrane and its preparation method and application

A technology of composite film and drying equipment, which is applied in the field of medical biomaterials, can solve the problems of not having drug loading, sustained release function, biological efficacy cycle that cannot fully meet clinical needs, and easy degradation, so as to improve the biological stability of collagen and improve Effect of Collagen and Drug Loading

Active Publication Date: 2021-04-20
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this import method is simple to operate, because the gaps of the natural bacterial cellulose membrane are very dense, and the natural collagen molecule size is large (300nm long), the amount of collagen import is often limited. At the same time, because the import collagen is a single molecule State, easy to degrade, easy to lose, short retention time in the body, biological efficacy cycle can not fully meet the clinical needs
The stability of collagen and composite membrane materials can be improved by chemical cross-linking technology, but it is often necessary to introduce non-biologically friendly chemical reagents, which have high cytotoxicity, which significantly reduces the biological safety of the product
[0008] Although the collagen / bacterial cellulose composite membrane materials currently reported have good biological safety, tensile properties, barrier properties, promotion of tissue healing, and self-degradation properties, they do not have drug loading and sustained release functions, which are difficult to meet clinical applications. Treatment needs of different types of wounds encountered during the process

Method used

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  • A kind of composite membrane and its preparation method and application
  • A kind of composite membrane and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Place the bacterial cellulose membrane in a beaker and soak it with enough deionized water for 24 hours to make it fully absorb water and swell. Then boil with 0.1mol / L NaOH solution for 30min, wash with deionized water until neutral, then transfer the cellulose membrane to 0.05mol / L acetic acid solution for soaking for 24h, wash with deionized water until neutral for later use. The purified aqueous bacterial cellulose membrane is placed in a freeze dryer, vacuumed, and the absolute pressure of the system is reduced to 20Pa within 5 minutes, and the bacterial cellulose membrane with large pores (such as figure 1 shown in A). Under the condition of 4-20° C., 0.1 M acetic acid was used to dissolve the type I collagen extracted from pig skin to obtain a collagen solution with a concentration of 5 mg / mL. Under the condition of 4-20°C, the phosphate buffer solution (i.e. PBS) with a pH of 7.0 was used as the dialysate, and the above collagen solution was dialyzed for 48 hou...

Embodiment 2

[0051] The difference from Example 1 is that the type I collagen extracted from grass carp skin was dissolved with 0.1 M acetic acid to obtain a collagen solution with a concentration of 8 mg / mL; the fibrosis treatment temperature was 25°C.

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Abstract

The invention discloses a composite membrane and its preparation method and application. The preparation method comprises: 1) purifying the bacterial cellulose membrane; 2) vacuumizing the bacterial cellulose membrane purified in step 1), and then freezing Dry to obtain bacterial cellulose membrane; 3) make natural collagen into natural collagen solution; 4) dialyze the natural collagen solution obtained in step 3), add medicine and mix uniformly; 5) introduce; 6) make step 5) obtain The bacterial cellulose membrane is subjected to fibrosis treatment; 7) vacuum treatment, and then freeze-drying to obtain the composite membrane. The invention can effectively improve the biological stability of the collagen and the retention stability in the film, so as to achieve the sealing effect of the medicine in the bacterial cellulose.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and more specifically relates to a composite membrane and its preparation method and application. Background technique [0002] Medical membrane materials are a type of clinical biomaterials that temporarily cover burns, wounds, ulcers and other wounds, and are widely used in clinical surgery fields such as burns and scalds, skin trauma and so on. Ideal medical membrane materials not only need to have good biological safety, suitable tensile properties, and barrier properties to external pollutants, but also have the properties of promoting tissue healing and self-degradation. More advanced medical membrane materials also need to have the function of loading and sustained release of therapeutic drugs, and are used to treat various skin wounds. In the traditional tissue wound drug administration methods such as smearing, the drug concentration on the wound can not only be maintained ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/42C08J5/18C08L1/02C08L89/00A61K9/70A61K47/38A61K47/42A61P17/02
CPCA61K9/7007A61K47/38A61K47/42A61P17/02C08J5/18C08J9/42C08J2301/02C08J2489/00
Inventor 张军涛汪海波未本美许承志何浪徐玉玲
Owner WUHAN POLYTECHNIC UNIVERSITY
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