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Liquid sampling apparatus

A liquid sampling and liquid technology, applied in the direction of sampling devices, etc., can solve the problems of large bubble content in the syringe, waste of sample solution, and long time-consuming dilution, and achieve the effect of saving liquid drainage time, saving extraction time, and shortening sampling time

Pending Publication Date: 2018-11-16
福建龙岩龙瑆医药科技有限公司
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AI Technical Summary

Problems solved by technology

[0003] Chinese patent document CN101639420A discloses a quantitative sampling device, including a mounting frame, a syringe, a sampling valve, and a displacement control mechanism. Control the movement of the piston above the piston of the syringe, and control the amount of sampled liquid by controlling the displacement distance of the piston of the syringe, but when the pipeline of the device is long, the pipeline resistance is large, and sampling takes a long time; during the sampling process The bubble content in the syringe is large, the sampling accuracy is low, and because the dissolution sample liquid contains particles, the piston is greatly worn
However, this method has the following disadvantages: (1) it is necessary to rinse the dilution device with the sample solution before drawing the sample, which wastes a part of the sample solution; (2) it needs to provide additional space for the dilution sample bottle; (3) the dilution takes a long time and the work low efficiency

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0042] Such as figure 1 As shown, a liquid sampling device includes a sampling pipeline, a liquid discharge pipeline and a plunger pump 8, and the plunger pump 8 is connected to the sampling pipeline and the liquid discharge pipeline, and is extracted from the sample cup 1 through the sampling pipeline. Liquid, the liquid is discharged into the sampling bottle through the liquid discharge pipeline; the setting structure of the plunger pump 8 can adopt the structure commonly used in the prior art, such as the plunger pump of a quantitative sampling device disclosed in CN101639420A mentioned in the background technology 8, the setting method does not belong to the improvement of the present invention, so it will not be described too much. In the present invention, a peristaltic pump 4 is added on the sampling pipeline. After the peristaltic pump 4 is turned on, it can pump liquid into the plunger pump 8; in order to coordinate the speed of the plunger pump 8 and the peristaltic ...

Embodiment 2

[0050] On the basis of the first embodiment, the sampling device further includes a liquid return pipeline and an intermediate pipeline. One end of the liquid return pipeline is connected to the plunger pump 8 through a valve, and is usually connected to the discharge pipeline through the three-way solenoid valve 213, and whether the plunger pump is connected to the discharge pipeline or not is realized by switching the three-way solenoid valve 213. Connected to the return line. The other end of the liquid return line is placed above the sample cup 1 . One end of the intermediate pipeline is connected to the liquid return pipeline, and the other end is connected between the peristaltic pump 4 and the filter 6 of the sampling pipeline. The intermediate pipeline is provided with a pressure tube valve 12 controlled by a controller. The pipeline is used for peristaltic pump 4 and previous pipeline flushing and filter 6 backwashing.

[0051] In the normal state, the pressure tube...

Embodiment 3

[0053] During the sampling process of the drug dissolution experiment, because the sampling consumes part of the solution, it is sometimes necessary to add a pure solution to the sample cup 1 for the drug dissolution. For this reason, on the basis of the second embodiment, the liquid sampling device of this embodiment also includes a liquid replacement tube. One end of the liquid replenishment tube is placed in the liquid replenishment cup 15 containing the pure solution to be replenished, and the other end is connected to the plunger pump 8 through a valve, usually connected to the sampling pipeline through a three-way solenoid valve 3 14, and the connection point is between the filter 6 and the first The pressure sensors 7 are as close as possible to the first pressure sensor 7, which can shorten the pipeline for pumping and supplementing the solution, and can also reduce the pipe resistance and shorten the time-consuming for pumping the solution. By monitoring the first pres...

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Abstract

The invention relates to a liquid sampling apparatus including: a sampling pipeline, a liquid discharge pipeline and a plunger pump which is connected to the sampling pipeline and liquid discharge pipeline, so that a liquid is sucked via the sampling pipeline and is discharged via the liquid discharge pipeline. The apparatus also includes: a peristaltic pump which is arranged on the sampling pipeline for pumping the liquid into the plunger pump; a controller for control coordinated action of the peristaltic pump and the plunger pump; a filter disposed between the peristaltic pump and the plunger pump; and a second pressure sensor and a first pressure sensor that are arranged at the front and the back of the filter. The controller controls the operation of the sampling apparatus according to pressure signals. In the apparatus, the liquid is sucked in a double-power manner, so that it is guaranteed that the interior of the plunger pump is under micro-positive pressure always. The structure not only increases suction speed of the liquid and reduces suction time, but also can avoid bubbles in the plunger pump and increases sampling precision.

Description

technical field [0001] The invention relates to a sampling device, which belongs to the fields of medicine, food and chemistry, in particular to a liquid sampling device. Background technique [0002] In the analysis experiment of the drug ingredients, it includes the dissolution sampling process, the device of the dissolution test of the drug, and the liquid in the cup is a suspension. According to the requirements of the dissolution test, it is necessary to take out an appropriate amount of solution for testing at a predetermined time point, and count from the sampling time point, and the filtration of the sample must be completed within 30 seconds. Existing dissolution sampling generally uses precision syringes or peristaltic pumps to sample the samples to be tested after the dissolution test into special test tubes. [0003] Chinese patent document CN101639420A discloses a quantitative sampling device, including a mounting frame, a syringe, a sampling valve, and a displ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/14
CPCG01N1/14
Inventor 郑陈业朱靖华苏超群
Owner 福建龙岩龙瑆医药科技有限公司
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