Hemorrhoid composition containing chitosan as well as preparation method and application thereof
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A chitosan and composition technology, applied in the field of medicine, can solve the problems of poor analgesic effect and anti-inflammatory effect, etc., and achieve the effects of being suitable for wide-scale popularization and application, significant therapeutic effect, and promoting ulcer healing effect.
Inactive Publication Date: 2018-11-23
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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[0006] In order to overcome the defects of poor analgesic effect and anti-inflammatory effect of hemorrhoid treatment drugs in the prior art, the present invention provides a hemorrhoid composition containing chitosan, which contains multiple drug components as its active ingredients, The components interact with each other, and have a significant synergistic effect on detumescence, analgesia, promotion of ulcer healing and hemostasis. It has a significant therapeutic effect on hemorrhoids, and its drug safety is suitable for popularization and application.
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Embodiment 1
[0020] Embodiment 1, the hemorrhoid composition containing chitosan
[0021] A hemorrhoid composition containing chitosan, which is prepared from the following components in percentage by weight: 1% chitosan, 0.5% alum, 0.1% borneol, 1% carbomer, 2% glycerin, 2% propylene glycol %, triethanolamine 2%, gelatin 20%, sodium hyaluronate 1%, and the balance water.
[0022] The preparation method of the hemorrhoid composition containing chitosan is: take by weighing chitosan, alum, borneol, carbomer, glycerin, propylene glycol, triethanolamine, gelatin, sodium hyaluronate and water and mix uniformly Grind it in a mortar to obtain a drug solution, melt the cocoa butter in a water bath at 80°C, add the drug solution, mix well, let cool until slightly viscous, pour it into a plug mold, let it solidify, and refrigerate it for 20 minutes, take it out and scrape it, After demoulding, the hemorrhoid composition containing chitosan is obtained.
Embodiment 2
[0023] Embodiment 2, the hemorrhoid composition containing chitosan
[0024] A hemorrhoid composition containing chitosan, which is prepared from the following components in percentage by weight: 5.5% chitosan, 2.75% alum, 1% borneol, 5.5% carbomer, 3% glycerin, 3% propylene glycol %, triethanolamine 3%, gelatin 30%, sodium hyaluronate 3%, and the balance water.
[0025] The preparation method of the hemorrhoid composition containing chitosan is the same as in Example 1.
Embodiment 3
[0026] Embodiment 3, the hemorrhoid composition containing chitosan
[0027] A hemorrhoid composition containing chitosan, which is prepared from the following components in percentage by weight: 10% chitosan, 5% alum, 2% borneol, 10% carbomer, 4% glycerin, 4% propylene glycol %, triethanolamine 4%, gelatin 40%, sodium hyaluronate 5%, and the balance water.
[0028] The preparation method of the hemorrhoid composition containing chitosan is the same as in Example 1.
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Abstract
The invention relates to a hemorrhoid composition containing chitosan as well as a preparation method and application thereof, and belongs to the field of medicines. The hemorrhoid composition containing the chitosan aims to overcome the technical defects of poor analgesic effect and anti-inflammatory effect of hemorrhoid treatment drugs in the prior art. The hemorrhoid composition containing thechitosan comprises the following components in percentage by weight: 1-10% of chitosan, 0.5-5% of alum, 0.1-2% of borneol, 1-10% of carbomer, 2-4% of glycerol, 2-4% of propylene glycol, 2-4% of triethanolamine, 20-40% of gelatin, 1-5% of sodium hyaluronate and 30-70% of water. The hemorrhoid composition containing the chitosan is prepared into a suppository. Compared with the prior art, The hemorrhoid composition containing the chitosan as well as the preparation method and the application thereof have the advantages of being capable of achieving significant detumescence, analgesia, ulcer healing promotion and hemostasis effects, capable of achieving significant therapeutic effect on hemorrhoids, capable of achieving significant progress and suitable for large-scale popularization and application.
Description
technical field [0001] The invention relates to a hemorrhoid composition containing chitosan, a preparation method and application thereof, belonging to the field of medicine. Background technique [0002] Hemorrhoids are a common disease located in the anus, which can occur at any age, but the incidence rate gradually increases with age. In my country, hemorrhoids are the most common anorectal disease. Hemorrhoids are divided into internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids according to the different parts of occurrence. At the junction of the skin of the anal canal and the mucous membrane of the rectum there is a jagged visible line called the dentate line of the anal canal. Above the dentate line are internal hemorrhoids, which are pathological changes or displacements of the supporting structure of the anal cushion, venous plexus, and arteriovenous anastomotic branch, covering the rectal mucosa. Due to the contraction of the internal sphincter, th...
Claims
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