Preparation method and application of oligopeptide hydrogel, and medicinal composition

A technology of hydrogel and composition, applied in the preparation method and application of short peptide hydrogel, and the field of pharmaceutical composition, can solve the problems of lack of selectivity of tumor tissue, affecting the ability of action, strong side effects and the like
CN108853515AActive Publication Date: 2018-11-23NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2018-11-23

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Abstract

The invention provides a preparation method and application of oligopeptide hydrogel, and a medicinal composition. The obtained oligopeptide hydrogel has a good targeting tumor suppression effect or in-vivo imaging effect. The preparation method of the oligopeptide hydrogel includes the steps of mixing oligopeptide with an antibody in a water solution, and assembling the oligopeptide and the antibody into the hydrogel under the enzymatic action at the temperature of 2-6 DEG C, wherein the oligopeptide can form the hydrogel under the enzymatic action, and the antibody has a targeting effect ontumor cells. The capping groups of the oligopeptide are groups having an antitumor effect or in-vivo imaging effect; preferably, the antitumor groups are chlorambucil, and the groups with the in-vivoimaging effect are Cy5.5; more preferably, the sequence of the oligopeptide is X-GDFDFpDY, and the X is chlorambucil or Cy5.5; preferably, the antibody is antiHER2.
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Description

technical field

[0001] The invention relates to a preparation method, application and pharmaceutical composition of a short peptide hydrogel. Background technique

[0002] The occurrence and development of cancer pose a serious threat to human health and social and economic development, and the number of people who die from cancer worldwide is increasing at an alarming rate every year. The World Cancer Report shows that the incidence of cancer worldwide is increasing rapidly. The number of cancer patients in the world will increase from 14 million in 2012 to 19 million in 2035, and will reach 24 million by 2050. Therefore, it has become urgent to continuously explore and develop more powerful cancer treatment methods to curb the huge threat of tumors to human health as soon as possible.

[0003] Traditionally, there are three main types of cancer treatment: chemotherapy, radiotherapy, and surgical resection. Among them, chemotherapy is mainly based on some chemotherapy dr...

Claims

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