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Nano drug carrier au/mno 2 And its preparation method and application

A nano-drug carrier, gold nanorod technology, applied in drug combination, pharmaceutical formula, anti-tumor drug, etc.

Active Publication Date: 2021-05-11
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are few literature and patent reports on MnO 2 Based hybrid materials applied to entrapment of antitumor drugs

Method used

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  • Nano drug carrier au/mno <sub>2</sub> And its preparation method and application
  • Nano drug carrier au/mno <sub>2</sub> And its preparation method and application
  • Nano drug carrier au/mno <sub>2</sub> And its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation of embodiment 1AuNRs

[0045] Dissolve 0.3645g of CTAB in 9.9mL of deionized water to prepare a CTAB solution with a concentration of 1mmol / L. After the CTAB is completely dissolved, add 100uL of HAuCl with a concentration of 25mmol / L to the CTAB solution 4 solution, the color of the solution changed from colorless and transparent to golden yellow, and was stirred in a constant temperature water bath at 28°C for 10 min. 0.6ml of NaBH with a concentration of 0.01mol / L 4 The solution was quickly added to the above mixed solution and stirred for 2 minutes. At this time, the color of the solution quickly changed from golden yellow to tea brown. The preparation of the seed solution was completed. The seed solution was kept in a constant temperature water bath at 28°C in the dark for 2 hours for later use. Add 3.645 g of CTAB to 100 mL of deionized water, stir in a constant temperature water bath at 30°C for 15 min, and add 2 mL of HAuCl with a concentration ...

Embodiment 2

[0047] The preparation of embodiment 2AuNRs

[0048] Dissolve 0.3 g of CTAB in 8.0 mL of deionized water to prepare a CTAB solution. After the CTAB is completely dissolved, add 40 uL of HAuCl with a concentration of 50 mmol / L to the CTAB solution 4 solution, the color of the solution changed from colorless and transparent to golden yellow, and was stirred in a constant temperature water bath at 28°C for 10 min. The 0.48ml concentration is the NaBH of 0.1mol / L 4 The solution was quickly added to the above mixed solution and stirred for 2 minutes. At this time, the color of the solution quickly changed from golden yellow to tea brown. The preparation of the seed solution was completed. The seed solution was kept in a constant temperature water bath at 28°C in the dark for 2 hours for later use. Add 3.0 g of CTAB to 90 mL of deionized water, stir in a constant temperature water bath at 30 °C for 15 min, and add 1 mL of HAuCl with a concentration of 50 mmol / L after the CTAB is co...

Embodiment 3

[0049] Example 3 Preparation of AuNRs

[0050] Dissolve 0.4 g of CTAB in 6.0 mL of deionized water to prepare a CTAB solution. After the CTAB is completely dissolved, add 70 uL of HAuCl with a concentration of 40 mmol / L to the CTAB solution 4 solution, the color of the solution changed from colorless and transparent to golden yellow, and was stirred in a constant temperature water bath at 28°C for 10 min. 2ml of NaBH with a concentration of 0.03mol / L 4 The solution was quickly added to the above mixed solution and stirred for 2 minutes. At this time, the color of the solution quickly changed from golden yellow to tea brown. The preparation of the seed solution was completed. The seed solution was kept in a constant temperature water bath at 28°C in the dark for 2 hours for later use. Add 4 g of CTAB to 95 mL of deionized water, stir in a constant temperature water bath at 30°C for 15 min, and add 20 mL of HAuCl with a concentration of 2.5 mmol / L after the CTAB is completely d...

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Abstract

The invention discloses a nano drug carrier Au / MnO 2 , the nano-drug carrier has a core-shell structure, with gold nanorods AuNRs as the core, mesoporous manganese dioxide MnO 2 It is the shell; the preparation method first uses the seed growth method to prepare AuNRs, and then utilizes the reaction of potassium permanganate and absolute ethanol in an alkaline or neutral environment to coat the surface of AuNRs with MnO with mesoporous structure. 2 , while improving the photothermal stability of AuNRs, to achieve the purpose of drug loading; the MnO 2 Combining with AuNRs can effectively improve its synergistic therapeutic effect. While further killing the original tumor, it can combine with GSH and H in the tumor microenvironment. + and H 2 o 2 The reaction decomposes into water and oxygen, relieves tumor hypoxia, improves tumor microenvironment, and effectively inhibits the growth of distant tumors, showing that MnO 2 The great application potential of base hybrid materials in the field of tumor therapy.

Description

technical field [0001] The invention belongs to drug carrier technology, in particular to a nano drug carrier Au / MnO 2 And its preparation method and application. Background technique [0002] According to data released by the World Health Organization (WHO) in 2017, the total number of cancer deaths in countries around the world is as high as 8.8 million each year, accounting for about 1 / 6 of the total annual death toll, and there are as many as 14 million new cancer cases each year. It is estimated that by 2030 In 2009, the annual new cases will reach 21 million, and cancer is still one of the major diseases that seriously endanger human life, health and life expectancy. Whether it is the number of deaths or new cases, China ranks first in the world. [0003] Gold nanorods (AuNRs) have tunable surface plasmon resonance (SPR) properties and good biocompatibility in the visible or near-infrared (NIR) region, and can become localized through the photothermal conversion effe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/02A61K31/704A61K41/00A61P35/00
CPCA61K9/5115A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 吉远辉张政
Owner SOUTHEAST UNIV
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