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Oral rehydration salt and preparation method thereof

A technology of rehydration salt and its content, which is applied in the field of oral rehydration salt and its preparation, to achieve the best therapeutic effect

Inactive Publication Date: 2018-11-30
ANHUI HEALSTAR PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the embodiments of the present invention is to provide an oral rehydration salt and its preparation method. In order to solve the problem of hypotonic rehydration salt III, the amount of electrolyte, glucose and water of the rehydration salt has not been found to reach a relatively stable equilibrium state, so that the effect of rehydration can reach A question of a relatively ideal state

Method used

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  • Oral rehydration salt and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0045] The oral rehydration salt of this embodiment, each 1000ml of the oral rehydration salt, contains the following millimoles (mmol) of various components:

[0046] Sodium chloride 79

[0047] Sodium citrate 2.2

[0048]Potassium chloride 2.2

[0049] Zinc chloride 2.1

[0050] Dextrose Anhydrous 60

[0051] Deionized water 91

[0052] Citric acid 1

[0053] And: the total sodium (Na + ) content is 83mmol / L, the total chlorine (Cl - ) content is 82mmol / L, the total potassium (K + ) content is 4.2mmol / L, and the pH value of the ORS is 6.2.

[0054] The specific preparation method is as follows:

[0055] S1: weigh various components respectively;

[0056] S2: Sodium chloride, sodium citrate and anhydrous glucose are added to deionized water, and the pH regulator citric acid is added dropwise at the same time to adjust the pH to 6.2, and the mixture is completely stirred to obtain the initial preparation;

[0057] S3: adding potassium chloride and zinc chloride to the ...

Embodiment 2

[0060] The oral rehydration salt of this embodiment, each 1000ml of the oral rehydration salt, contains the following millimoles (mmol) of various components:

[0061] Sodium chloride 81

[0062] Sodium citrate 2.4

[0063] Potassium chloride 5.6

[0064] Zinc chloride 3.2

[0065] Dextrose Anhydrous 80

[0066] Deionized water 110

[0067] citric acid 2

[0068] And: the total sodium (Na + ) content is 94mmol / L, the total chlorine (Cl - ) content is 95mmol / L, the total potassium (K + ) content is 8.9mmol / L, and the pH value of the ORS is 6.4.

[0069] The specific preparation method is as follows:

[0070] S1: weigh various components respectively;

[0071] S2: Sodium chloride, sodium citrate and anhydrous glucose are added to deionized water, and the pH regulator citric acid is added dropwise at the same time to adjust the pH to 6.4, and the mixture is completely stirred to obtain the initial preparation;

[0072] S3: adding potassium chloride and zinc chloride to th...

Embodiment 3

[0075] The oral rehydration salt of this embodiment, each 1000ml of the oral rehydration salt, contains the following millimoles (mmol) of various components:

[0076] Sodium chloride 80

[0077] Sodium citrate 2.3

[0078] Potassium chloride 3.9

[0079] Zinc chloride 2.6

[0080] Dextrose Anhydrous 70

[0081] Deionized water 100

[0082] Lactic acid and malic acid 1.5

[0083] And: the total sodium (Na + ) content is 88mmol / L, the total chlorine (Cl - ) content is 89mmol / L, the total potassium (K + ) content is 6.6mmol / L, and the pH value of the ORS is 6.3.

[0084] The specific preparation method is as follows:

[0085] S1: weigh various components respectively;

[0086] S2: Sodium chloride, sodium citrate and anhydrous glucose are added to deionized water, and pH regulator lactic acid and malic acid are added dropwise at the same time to adjust the pH to 6.3, stirred and mixed completely, and the initial preparation is obtained;

[0087] S3: adding potassium chlor...

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Abstract

The invention discloses oral rehydration salt and a preparation method thereof. Every 1,000ml of the oral rehydration salt comprises the following components by mmol: 79-81mmol of sodium chloride, 2.2-2.4mmol of sodium citrate, 2.2-5.6mmol of potassium chloride, 2.1-3.2mmol of zinc chloride, 60-80mmol of anhydrous glucose, 91-110mmol of deionized water, 1-2mmol of a pH regulator, wherein the content of total sodium (Na<+>) is 83-94mmol / L, the content of total chlorine (Cl<->) is 82-95mmol / L and the content of total potassium (K<+>) is 4.2-8.9mmol / L of; and the pH value of the oral rehydrationsalt is 6.2-6.4. According to the oral rehydration salt and the preparation method, the pH regulator is dropwise added for enabling the pH value to be 6.2-6.4 while the anhydrous glucose is added intothe deionized water, so that the anhydrous glucose is enabled to be in a liquid with the pH value of 6.2-6.4 all the time, the anhydrous glucose is guaranteed to be almost not degraded, an obtained product is stable, and a treatment effect is relatively good.

Description

technical field [0001] The invention relates to a rehydration salt and a preparation method thereof, in particular to an oral rehydration salt and a preparation method thereof. Background technique [0002] Oral rehydration salts have gone through three stages: rehydration salts I, rehydration salts II, and rehydration salts III. Rehydration salt I contains sodium chloride, potassium bicarbonate, potassium chloride and anhydrous glucose; rehydration salt II replaces potassium bicarbonate in rehydration salt I with sodium citrate, because sodium bicarbonate is prone to deliquescence, and In the formula, sodium citrate is replaced by sodium bicarbonate, which is convenient for storage and tastes better; rehydration salt Ⅰ and rehydration salt Ⅱ are hypertonic solutions, and the indications are only for mild dehydration caused by hydropower disorder and diarrhea caused by cholera disease, and Due to its hypertonicity, it is easy to induce hypernatremia, so a safer and more eff...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61P1/12A61P3/12A61K33/14A61K31/7004A61K31/194
CPCA61P1/12A61P3/12A61K31/194A61K31/7004A61K33/14A61K33/30A61K2300/00
Inventor 刘经星牛春霞
Owner ANHUI HEALSTAR PHARM CO LTD
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