Shark cartilage glycoprotein and anti-cancer application thereof

Abstract

The invention relates to a shark cartilage glycoprotein and an anti-cancer application thereof. The shark cartilage glycoprotein is prepared by crushing shark cartilage; extracting the shark cartilagewith alkaline water; and salting out, removing free proteins and purifying the shark cartilage to obtain an active component of the shark cartilage. A pharmacological experiment displays that the shark cartilage glycoprotein has remarkable anti-angiogenesis action and also can inhibit proliferation of cells such as skin cancer, breast cancer, non-small cell lung cancer, liver cancer, gastric cancer and ovarian cancer. An in vivo experiment also shows an excellent anti-tumor effect, and the shark cartilage glycoprotein can be widely applied to preventing and treating cancers.

Description

technical field

[0001] The invention belongs to the field of medicines, and in particular relates to a shark cartilage glycoprotein and its anticancer application. Background technique

[0002] Cancer, also known as malignant tumor, refers to a type of disease in which cells proliferate uncontrollably caused by the abnormality of the mechanism of controlling cell proliferation, and locally invade the surrounding normal tissues, and even transfer to other parts of the body through the internal circulatory system or lymphatic system. . Because cancer has no obvious clinical symptoms in its early stage, it is often in the advanced stage when it is discovered, and the optimal treatment window period is often missed when it is discovered, resulting in a high fatality rate and becoming one of the five terminal diseases in the world. my country is one of the areas with a high incidence of cancer, and the incidence of cancer has been increasing year by year in recent years. In 2014...

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