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Sodium acetate Ringer's glucose injection and preparation method thereof

A technology of glucose injection and sodium acetate, applied in the field of injection, can solve the problems of lactic acidosis, insufficient adjustment of acid-base balance, etc., and achieve the effects of stable quality, high qualified rate of finished products, and cost reduction

Inactive Publication Date: 2018-12-11
ANHUI DOUBLE CRANE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound sodium lactate glucose injection is widely used on the market, the main function is to replenish water and electrolytes, and the adjustment of acid-base balance is not significant enough; moreover, lactic acidosis is prone to occur

Method used

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  • Sodium acetate Ringer's glucose injection and preparation method thereof
  • Sodium acetate Ringer's glucose injection and preparation method thereof
  • Sodium acetate Ringer's glucose injection and preparation method thereof

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Embodiment 1

[0021] Sodium acetate Ringer's dextrose injection, hour stage, each 5L sodium acetate Ringer's dextrose injection contains the following raw materials:

[0022]

[0023] The preparation method of above-mentioned sodium acetate Ringer's dextrose injection comprises the following steps:

[0024] 1), sodium acetate trihydrate, open the dilute preparation tank, add 30% of the formula amount of water for injection at 60°C, add the formula amount of anhydrous glucose, sodium chloride, potassium chloride, and calcium chloride dihydrate, and stir to dissolve; Add the sodium acetate trihydrate of formula quantity, stir to dissolve;

[0025] 2) Add 60% of the formulated amount of water for injection at 60°C to the mixed solution described in step 1), circulate for 15-25 minutes, and then add the formulated amount of hydrochloric acid to adjust the pH to 5.2±0.1;

[0026] 3), then add the remaining formula amount of water for injection at 60°C, stir and mix;

[0027] 4) Intermediate...

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Abstract

The invention provides a sodium acetate Ringer's glucose injection, and each 1000 ml sodium acetate Ringer's glucose injection contains the following raw materials: 50 g of anhydrous glucose, 6 g of sodium chloride, 0.3 g of potassium chloride, 0.2 g of calcium chloride dihydrate, 3.8 g of sodium acetate trihydrate, 5 ml of hydrochloric acid and the rest of injection water. Compared with the priorart, the invention uses sodium acetate instead of sodium lactate in compound sodium lactate glucose injection to reduce the possibility of lactic acidosis. Compared with sodium lactate Ringer's injection, the invention does not increase the lactic acid in blood of patients; and in addition, adding of glucose can increase energy supply while supplementing electrolytes. The preparation method comprises the following steps: processing for 10 to 12 minutes at the condition of 121 DEG C to reach a pH value which is between 5.1 and 5.3, controlling the temperature of injection water to control theresidual oxygen in material liquid, and introducing nitrogen from the opening when bottling to reduce the production of 5-hydroxymethylfurfural.

Description

technical field [0001] The invention belongs to the field of injections, in particular to sodium acetate Ringer's dextrose injection and a preparation method thereof. Background technique [0002] Compound Sodium Lactate Glucose Injection is used as a body fluid supplement to regulate body fluid, electrolyte and acid-base balance. In cases of dehydration with metabolic acidosis or a predisposition to metabolic acidosis requiring calorie supplementation. [0003] At present, the compound sodium lactate glucose injection is widely used in the market, the main function is to replenish water and electrolytes, and the adjustment of acid-base balance is not significant enough; moreover, lactic acidosis is prone to occur. Contents of the invention [0004] The object of the present invention is to provide sodium acetate Ringer's dextrose injection, utilize sodium acetate to replace the sodium lactate in compound sodium lactate dextrose injection, can not increase the lactic acid...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7004A61K47/12A61P7/08
CPCA61K9/0019A61K9/08A61K31/7004A61K47/12A61P7/08
Inventor 周国宁曹宗培张立明董春浩何玲利
Owner ANHUI DOUBLE CRANE PHARMA
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