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A method for preparing disodium glycyrrhizinate

A technology of disodium glycyrrhizinate and monoammonium glycyrrhizinate, applied in the field of chemistry, can solve the problems of residual ammonium, low yield, poor product quality and the like, achieves easy operation, improved product quality and yield, and simple process. Effect

Inactive Publication Date: 2018-12-14
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above problems, the purpose of the present invention is to provide a preparation method of disodium glycyrrhizinate, which solves the problems of low yield, poor product quality and residual ammonium in the product.

Method used

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  • A method for preparing disodium glycyrrhizinate
  • A method for preparing disodium glycyrrhizinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 300g monoammonium glycyrrhizinate, add 1200mL 20% ethanol and stir to dissolve, add 600g cation exchange resin and stir for a period of time, filter to obtain the converted solution of monoammonium glycyrrhizinate, add 5% activated carbon by weight of monoammonium glycyrrhizinate Stir and decolorize in a water bath at 40°C for 1 hour, add 20 g of sodium hydroxide to the decolorized solution after filtration, stir for 30 minutes, concentrate to remove ethanol, and spray-dry the concentrated solution obtained by filtration at 70°C to obtain 288.0 g of the finished product of disodium glycyrrhizinate, yield It is 93.2%, and the product purity is 84.6%, and the liquid chromatogram sees figure 1 .

Embodiment 2

[0024] Weigh 400g of monoammonium glycyrrhizinate, add 2000mL of 30% ethanol and stir to dissolve, add 1200g of cation exchange resin and stir for a period of 1.5h, filter to obtain the converted solution of monoammonium glycyrrhizinate, add 8% by weight of monoammonium glycyrrhizinate Activated carbon was stirred and decolorized in a water bath at 50°C for 1.5h, filtered to obtain a decolorized solution, added 27g of sodium hydroxide, stirred for 30min, concentrated to remove ethanol, and the concentrated solution obtained by filtration was spray-dried at 70°C to obtain 380.0g of the finished product of disodium glycyrrhizinate. Yield is 92.2%, and product purity is 83.7%, and liquid chromatogram sees figure 2 .

Embodiment 3

[0026] Weigh 500g of monoammonium glycyrrhizinate, add 3000ml of 40% ethanol and stir to dissolve, add 2000g of cation exchange resin and stir for a period of 12 hours, filter to obtain the converted solution of monoammonium glycyrrhizinate, add 10% activated carbon by weight of monoammonium glycyrrhizinate Stir and decolorize in a water bath at 60°C for 2 hours, add 33g of sodium hydroxide to the decolorized solution after filtration, stir for 30min, concentrate to remove ethanol, and spray-dry the concentrated solution obtained by filtration at 70°C to obtain 475.0g of the finished product of disodium glycyrrhizinate. It is 92.2%, and the product purity is 82.6%.

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Abstract

A method for preparing disodium glycyrrhizinate is disclosed, and belongs to the field of chemistry. The method includes 1) weighing mono-ammonium glycyrrhizinate, adding a solvent and stirring the mixture at room temperature to allow the mono-ammonium glycyrrhizinate to be dissolved; 2) adding cation exchange resin after the mono-ammonium glycyrrhizinate is dissolved, stirring the mixture at roomtemperature, and filtering the mixture to obtain filtrate so as to obtain a solution after conversion of the mono-ammonium glycyrrhizinate; and 3) adding activated carbon into the solution after conversion of the mono-ammonium glycyrrhizinate, stirring and decoloring the mixture, performing filtration to obtain a filtrate, adding a sodium salt into the filtrate, stirring the mixture, concentrating the mixture to remove the solvent, performing filtration to obtain a filtrate and spray-drying the filtrate to obtain a disodium glycyrrhizinate finished product. The method is simple in process andeasy to operate, greatly reduces ammonium salt residues in the product, improves product yield and quality and can achieve industrial production.

Description

technical field [0001] The invention belongs to the field of chemistry, and relates to a preparation method of disodium glycyrrhizinate. technical background [0002] The chemical name of disodium glycyrrhizinate is also known as 20β-carboxylic acid-11-oxo-n-oleanane-12-en-3β-2-O-β-D-glucopyranosyl-α-D-glucoside Pyranosidic aldehyde disodium salt, white or light yellow powder, very sweet taste, with a special sweet aftertaste. Disodium glycyrrhizinate also has the effect of increasing flavor, which can be used as a flavoring agent for edible spices, and has a better effect on dairy products and cocoa products. In addition, disodium glycyrrhizinate is also a natural food sweetener, which is extracted from the natural plant licorice and processed by a special process. The main ingredient is glycyrrhizic acid, which is 200-300 times sweeter than sucrose. It is very soluble in water. The solution is clear and transparent, free of impurities and strange smells, and has a good t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07H1/00C07J63/00
CPCC07H1/00C07H15/256C07J63/008
Inventor 季浩闫成亮刘佳阚建伟窦长清孔繁博徐娟
Owner JIANGSU TIANSHENG PHARMA
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