A kind of glue type traditional Chinese medicine instant preparation and its non-adjuvant direct compression technology method

An excipient-free, instant technology, applied in pharmaceutical formulations, drug combinations, unknown raw materials, etc., can solve the problems of less than 20% utilization rate of powder direct tableting process, unable to meet the needs of packaging, storage and transportation, and poor product brittleness. The effect of enhancing immunity, high brittleness, and low powder drop rate

Active Publication Date: 2020-11-13
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, domestic tablet production is still dominated by wet or dry granulation and tablet compression, and the utilization rate of powder direct compression technology is still less than 20%.
Pressed products usually require very high pressure. If the pressure is too high, the product needs to gradually dissolve from the outside to the inside. The dissolution is slow, the experience is poor, and the product is brittle. Shipping needs

Method used

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  • A kind of glue type traditional Chinese medicine instant preparation and its non-adjuvant direct compression technology method
  • A kind of glue type traditional Chinese medicine instant preparation and its non-adjuvant direct compression technology method
  • A kind of glue type traditional Chinese medicine instant preparation and its non-adjuvant direct compression technology method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take the donkey-hide gelatin coarse powder, place it in a pulverizer, pulverize and sieve to obtain 40-60 mesh donkey-hide gelatin powder;

[0036] The ethanol (wetting agent) of 90% volume concentration is added in donkey-hide gelatin powder with the consumption of 20% to make soft material, seal and infiltrate 4min, adopt briquetting machine to press into briquette, the host speed of described briquetting is 4r / min, and filling speed It is 15 times of the speed of the main machine; the filling depth is 8mm, the main pressing thickness is 6mm, and the pre-pressing thickness is 1.6 times of the main pressing thickness. The upper and lower punches of the tablet are sprayed and pre-coated with alcohol at the position before contacting the sample: the alcohol concentration is 93%, and the atomization area is 770mm 2 , the spray volume is 0.35ml / time. After tableting, vacuum-dry at 30° C. with a vacuum degree of 0.03 MPa for 80 minutes to obtain donkey-hide gelatin instant...

Embodiment 2

[0045] Take the donkey-hide gelatin coarse powder, put it in a pulverizer, pulverize and sieve to obtain 40-60 mesh donkey-hide gelatin powder;

[0046] The ethanol (wetting agent) of 90% volume concentration is added in donkey-hide gelatin powder with the consumption of 20% to make soft material, seal and infiltrate 4min, adopt briquetting machine to press into briquetting, the host speed of described briquetting is 5r / min, and filling speed It is 75r / min; the filling depth is 8mm, the main pressing thickness is 6mm; the pre-pressing thickness is 1.6 times of the main pressing thickness. In the present invention, the upper and lower punches of the tablet use alcohol to carry out spray pre-coating at the position before contacting the sample: the alcohol concentration is 93%, and the atomization area is 780mm 2 , the spray volume is 0.3ml / time. After tableting, vacuum-dry at 30° C. with a vacuum degree of 0.03 MPa; vacuum-dry for 60 minutes to obtain donkey-hide gelatin insta...

Embodiment 3

[0056] Take the donkey-hide gelatin coarse powder, place it in a pulverizer, pulverize and sieve to obtain 50-60 mesh donkey-hide gelatin powder;

[0057] The ethanol (wetting agent) of 91% volume concentration is added in donkey-hide gelatin powder with the consumption of 20% to make soft material, seal and infiltrate 4min, press into agglomerate, the host speed of described briquetting is 6r / min, and the filling speed is 1 / 2 of the host speed. 15 times; the filling depth is 9mm, the main pressing thickness is 7mm, and the pre-pressing thickness is 1.6 times of the main pressing thickness. The upper and lower punches of the tablet are sprayed and pre-coated with alcohol at the position before contacting the sample: the alcohol concentration is 93%, and the atomization area is 760mm 2 , the amount of spraying is 0.4ml / time, after tableting, vacuum-dry at 40°C with a vacuum degree of 0.04Mpa, and vacuum-dry for 80min to obtain instant donkey-hide gelatin blocks. The prepared d...

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Abstract

The invention provides a gel-type traditional Chinese medicine instant preparation and an ingredient-free direct pressing technological method, which belongs to the technical field of gel-type traditional Chinese medicine preparation. The direct pressing molding method comprises the following steps: (1) crushing donkey-hide gelatin coarse powder to obtain donkey-hide gelatin powder; (2) mixing anethanol aqueous solution with a volume concentration of 88 to 93 percent and the donkey-hide gelatin powder to obtain a soft material; and (3) firstly briquetting the soft material, and then drying toobtain donkey-hide gelatin instant blocks. The donkey-hide gelatin instant blocks obtained by adopting the method of the invention is crispy (the crispness is 0.05 to 0.20N / mm<2>), homogenous in color, good in instant solubility (the block can be dissolved in 10s), low in particle dropping rate (less than or equal to 0.5 percent), capable of being integrally disintegrated, and capable of being scattered instantly in water, has efficacies for nourishing the blood, stopping the bleeding, nourishing Yin, moistening the dryness, and improving the immunity, can be instantly eaten, are rich in nutritional value, and can meet the requirements of consumers for a supplement such as health, deliciousness and convenience.

Description

technical field [0001] The invention belongs to the technical field of gelatinous traditional Chinese medicine preparation, and in particular relates to a gelatinous traditional Chinese medicine instant preparation and a direct-pressing method without auxiliary materials. Background technique [0002] Gum-like Chinese herbal medicines are unique to China and have a long history of application. Especially donkey-hide gelatin, which has been honored as the "sacred medicine" for blood enrichment by ancient physicians, has been called "three treasures of traditional Chinese medicine" together with ginseng and velvet antler since ancient times. Modern studies have proved that donkey-hide gelatin is rich in collagen, peptides and various amino acids. It is a blood-tonifying drug commonly used in traditional Chinese medicine. [0003] Traditional glues such as donkey-hide gelatin need to be melted or powdered and boiled before taking, which is inconvenient to take. Lumpy products...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/02A61K35/36A61K9/16A61P7/06A61P1/14A61P37/04
CPCA61K9/1617A61K35/36A61P1/14A61P7/06A61P37/04
Inventor 孙阳恩金玉翠王春艳张淹刘海滨田守生史兆松周祥山
Owner SHAN DONG DONG E E JIAO
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