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Preparation method of novel conductive hydrogel with super stable electrochemical signal

An electrochemical and hydrogel technology, applied in the field of preparation of electrochemical signal ultra-stable hydrogel, can solve problems such as unstable indicator signal, and achieve the effects of short reaction time, good conductivity and simple preparation method

Active Publication Date: 2018-12-18
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the biggest problem in the clinical application of electrochemical immunoassay is the instability of the indicator signal. If an immunosensing substrate with ultra-stable electrical signals can be found, it will promote great progress in electrochemical immunosensing.

Method used

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  • Preparation method of novel conductive hydrogel with super stable electrochemical signal
  • Preparation method of novel conductive hydrogel with super stable electrochemical signal
  • Preparation method of novel conductive hydrogel with super stable electrochemical signal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of thionine hydrogel

[0036] 1) Disperse 1 part by weight of potassium chloride in about 100 parts by weight of deionized water to form a uniformly dispersed potassium chloride solution; disperse 1 part by weight of aniline in about 75 parts by weight of deionized water to form a soluble aniline dispersion ; The phytic acid of 1 weight part is dispersed in the deionized water of about 80 weight parts to form soluble phytic acid dispersion liquid;

[0037] 2) Then the obtained potassium chloride dispersion, soluble aniline solution and soluble phytic acid solution were mixed, and then reacted by electrodeposition under the condition of constant potential -0.2 to 1.2v for 10s. The weight ratio of the potassium chloride, the aniline and the phytic acid is preferably 1:0.1:0.33, and the reaction temperature is 30° C., so that an ultra-stable aniline hydrogel can be obtained.

[0038] 3) Disperse 1 part by weight of thionine in about 100 parts...

Embodiment 2

[0040] Embodiment 2: the preparation of aniline methylene blue hydrogel

[0041] 1) Disperse 1 part by weight of potassium chloride in about 100 parts by weight of deionized water to form a uniformly dispersed potassium chloride solution; disperse 1 part by weight of aniline in about 75 parts by weight of deionized water to form a soluble aniline dispersion ; The phytic acid of 1 weight part is dispersed in the deionized water of about 80 weight parts to form soluble phytic acid dispersion liquid;

[0042] 2) Then the obtained potassium chloride dispersion, soluble aniline solution and soluble phytic acid solution were mixed, and then reacted by electrodeposition under the condition of constant potential -0.2 to 1.2v for 10s. The weight ratio of the potassium chloride, the aniline and the phytic acid is preferably 1:0.1:0.33, and the reaction temperature is 30° C., so that an ultra-stable aniline hydrogel can be obtained.

[0043] 3) Dispersing 1 part by weight of methylene b...

experiment Embodiment 1

[0048] Electrode pretreatment: the glassy carbon electrode is sequentially treated with A1 2 o 3 Powder polished to a mirror surface, then ultrasonically cleaned with ethanol, acetone, and water in sequence, and blown dry by dry nitrogen. Put the electrode treated by physical method into 0.5mol·L -1 H 2 SO 4 The electrode surface was further cleaned and activated by electrochemical methods in the potential range of -0.3V-1.5V by cyclic voltammetry, and the treated electrode was placed in secondary water for standby.

[0049] Afterwards, 15 μL of the thionine hydrogel prepared in Example 1 was reacted with the surface of the glassy carbon electrode at 30° C. for 30 minutes, and then the surface was washed with deionized water. In the selected supporting electrolyte (phosphate buffer solution: 0.1mol L -1 , pH 7.0), measured at room temperature. All electrochemical measuring instruments are CHI832 electrochemical analyzers connected to a computer, through a traditional thr...

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Abstract

The invention provides a preparation method of a hydrogel with a super stable electrochemical signal. The method comprises the following steps: preparing a polyaniline conductive hydrogel from aniline, phytic acid and potassium chloride through one-step electrodeposition, adsorbing an electric signal material organic dye small-molecules, and performing a reaction to finally form the hydrogel withthe super stable electrochemical signal. The method has the advantages of short reaction time, simplicity and certain universality. The prepared hydrogel material has the advantages of good mechanicalproperties, large specific surface area, three-dimensional network structure, good electrical conductivity, and super stable electrochemical signal.

Description

technical field [0001] The invention relates to the field of preparation of chemical materials, in particular to a preparation method of a class of electrochemical signal superstable hydrogel. Background technique [0002] Hydrogels have a large specific surface area and a unique three-dimensional network structure, so hydrogels can carry a large number of molecules with different functions, endowing them with multifunctionality, such as good electrical conductivity, strong electrochemical signals, and excellent catalytic capabilities Wait. Meanwhile, the microenvironment of the hydrogel can enhance the stability and bioactivity of biomolecules. In addition, the high permeability of hydrogels can accelerate the transport of small molecules and ions, as well as the rapid transfer of electrons. These unique properties make hydrogels show great potential in constructing electrochemical immunosensing interfaces. [0003] Since the three-dimensional porous structure of the con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L79/02C08K5/521C08K3/16C08K5/46C08G73/02
CPCC08G73/0266C08J3/075C08J2379/02C08K3/16C08K5/46C08K5/521
Inventor 马占芳王辉强
Owner CAPITAL NORMAL UNIVERSITY