Nano-vesicle preparation covering vitamin D and vitamin K and application thereof

Abstract

The invention provides a nano-vesicle preparation covering vitamin D and vitamin K and application thereof. The nano-vesicle preparation covering the vitamin D and the vitamin K is prepared from, in parts by mass, 1-3 parts of the vitamin D, 3-7 parts of the vitamin K and 30-100 parts of vesicle auxiliary. A preparation process of the nano-vesicle preparation comprises the step that after the vesicle auxiliary, the vitamin D and the vitamin K are dissolved in a solvent, even dispersion is conducted to obtain a vesicle solution. According to the nano-vesicle preparation covering the vitamin D and the vitamin K and the application thereof, by adopting a vesicle covering technology, the vitamin D and the vitamin K are covered to prepare the nano-vesicle preparation, the vitamin D and the vitamin K can be directly delivered into blood, and the efficacy can be improved by at least dozens of times compared with that of a traditional oral preparation. A novel method is provided for osteoarthritis studying, and an innovative means is provided for curing and preventing osteoarthritis.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a nanovesicle preparation coated with vitamin D and vitamin K and its application; in particular, it relates to a nanovesicle preparation coated with vitamin D and vitamin K and the preparation of the nanovesicle preparation Use of a drug for the treatment of osteoarthritis. Background technique [0002] Osteoarthritis is the most common form of arthritis, most commonly affecting the knee joint. It can cause pain and disability, seriously affecting people's ability to work and quality of life. According to the World Health Organization, the global prevalence of symptomatic osteoarthritis in people over 60 years old is 9.6% for men and 18% for women. In 2010, there were approximately 251 million knee osteoarthritis patients worldwide, accounting for 3.6% of the total population. Due to the increase in the average human life expectancy and the inc...

AI Technical Summary

Problems solved by technology

[0005] The compound preparations of vitamin D and vitamin K are mainly made into ordinary capsules and tablets. However, since both vitamin D and vitamin K are fat-soluble, it is difficult for them to enter the blood circulation, so their bioavailability is low.