Traditional Chinese medicine active component composition for treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases, active ingredients, applied in cardiovascular system diseases, organic active ingredients, drug combinations, etc., can solve problems such as lack of compatibility

Active Publication Date: 2018-12-21
苏州立宸生物技术有限公司
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  • Abstract
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Problems solved by technology

[0009] Although the relevant pharmacological mechanisms of the three active ingredients have been reported, however, they have not been rationally compatible

Method used

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  • Traditional Chinese medicine active component composition for treating cardiovascular and cerebrovascular diseases

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Embodiment Construction

[0021] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0022] Kunming mice were fasted for 12 hours after being fed for 4 weeks. A blank control group (feeding basal feed), a hyperlipidemia control group (feeding high-fat feed), a single-component experimental group and a group-matching experimental group were set up. During the experiment period, free to drink water and food, intraperitoneal injection (0.2mL) once a day at a dose of 8mg / kg in the morning and evening, for 2 consecutive weeks. After the last administration, all animals were fasted for 12 hours, and blood was collected from the fundus vein. The blood was placed in a water bath at 37°C for 30 minutes, and centrifuged at 3500r / min for ...

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Abstract

The invention discloses a traditional Chinese medicine active component composition for treating cardiovascular and cerebrovascular diseases. The traditional Chinese medicine active component composition is prepared by mixing two or three of pachymic acid, magnolol and 10-hydroxyl-removed gingerdione. Under the best combination, two or three components can be combined to remarkably reduce contentof TC, TG and LDL-C and increase content of HDL-C. After the two components are combined, four indexes cannot completely reach the blank control group level, but are close to the level of the blank control group. Three components can be combined for reducing the values of the four indexes or increasing the values to the blank control level.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine active ingredient composition for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Atherosclerosis (AS) refers to the deposition of fat on the arterial wall, because the appearance of the intima is yellowish white, similar to rice porridge, so it is called atherosclerosis. The deposition of these lipids thickens and reduces the elasticity of the arterial wall, thereby hardening the blood vessel, so it is called atherosclerosis. Abnormal cholesterol metabolism is an important risk factor for atherosclerotic damage. Epidemiological studies have confirmed that low-density lipoprotein (LDL) or low-density lipoprotein cholesterol (LDL-C) is an important pathogenic factor for atherosclerosis , while plasma high-density lipoprotein cholesterol (HDL-C) levels are negatively correlated with the occu...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K31/05A61K31/12A61P9/00
CPCA61K31/05A61K31/12A61K31/575A61P9/00A61K2300/00
Inventor 缪国鹏韩娟张际峰童贯和武以海
Owner 苏州立宸生物技术有限公司
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