Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method of improving the appearance of periorbital dyschromia

A technology for abnormal pigmentation and appearance, applied in pharmaceutical formulations, skin care preparations, medical preparations containing active ingredients, etc., can solve problems such as no universally recognized definition of types, periorbital pigmentation abnormalities, etc.

Inactive Publication Date: 2018-12-21
THE PROCTER & GAMBLE COMPANY
View PDF21 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it is generally known that different types of periorbital pigmentary abnormalities may exist, there is no universally accepted definition for each type

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of improving the appearance of periorbital dyschromia
  • Method of improving the appearance of periorbital dyschromia
  • Method of improving the appearance of periorbital dyschromia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1—formulation embodiment

[0076] Table 2 shows five exemplary oil-in-water emulsion cosmetic compositions for use in the method according to the invention. Compositions A to E can be prepared as follows. In a suitable vessel the aqueous phase ingredients are combined and heated to 75°C. In a separate suitable vessel, combine the oil phase ingredients and heat to 75°C. Add the oil phase to the water phase and grind the resulting emulsion (eg with TEKMAR TM T-25 or equivalent). Add the thickener to the emulsion and cool to 45°C while stirring. At 45°C, the remaining ingredients were added. The product was cooled to 30°C with stirring and poured into suitable containers.

[0077] Table 2

[0078]

[0079]

[0080] 1 palmitoyl-lysine-threonine-threonine-lysine-serine, purchased from Sederma (France)

[0081] 2 Titanium dioxide coated mica, purchased from Kobo Products Inc.

[0082] 3 tapioca starch and polymethylsilsesquioxane from Akzo Nobel ...

Embodiment 2

[0114] Example 2: In vivo studies (VPS, blood perfusion and imaging)

[0115] This example demonstrates the ability of the methods of the invention to improve the appearance of Type II and Type III periorbital dyspigmentations. Twenty-five Caucasian female subjects aged 20 to 60 years participated in a nine-week faceted round-robin design study to evaluate the ability of pumpkin seed extract to improve the appearance of type II and type III periorbital dyspigmentation. The oil-in-water emulsion of Example R from Table 5 was evaluated in this study.

[0116] During the study, the sub-eye portion of the periorbital area on the left side of the face of the test subjects (i.e. Figure 4A Shaded area 400 in ), and the undereye portion of the periorbital area on the right side of the test subject's face was treated with a vehicle control (i.e., the same composition as the test composition, except without the pumpkin seed extract) . Test subjects were instructed to use the clean...

Embodiment 3

[0136] Example 3: In vitro studies (B16 - melanin assay)

[0137] This example demonstrates that pumpkin seed extract has no ability to inhibit melanin synthesis. Excess melanin is believed to be a major contributor to the appearance of type I periorbital dyspigmentation, but not type II. Therefore, treatment of type I periorbital dyspigmentation with pumpkin seed extract should not provide any improvement in its appearance, as demonstrated by the lack of melanin-suppressive activity in conventional B16 assays. This is important because it shows that a "one size fits all" approach may not be the best way to treat all types of periorbital melanoma. For example, a composition utilizing pumpkin seed extract may not improve the appearance of type I periorbital dyspigmentation.

[0138] In this example, a commercially available B16-F1 mouse melanoma cell line from the American Tissue Culture Collection (Virginia, USA) was used in a conventional melanin synthesis inhibition assa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Login to View More

Abstract

A method of improving the appearance of periorbital dyschromia by identifying a target portion of skin in the periorbital region of a person that exhibits periorbital dyschromia and applying a personal care composition to the target portion of skin. The personal care composition includes an effective amount of an extract of Cucurbita pepo and a dermatologically acceptable carrier. The personal care composition is applied for a sufficient amount of time for the extract of Cucurbita pepo to improve the appearance of the periorbital dyschromia.

Description

technical field [0001] The present disclosure generally relates to methods of improving the appearance of periorbital dyspigmentation. More specifically, the present disclosure relates to improving the appearance of one or more types of periorbital dyspigmentation by applying a cosmetic composition comprising zucchini extract to periorbital skin in need of such treatment. Background technique [0002] Periorbital dyspigmentation, which is sometimes called dark circles, is generally considered an undesirable discoloration of the skin around the eyes and is often associated with fatigue and / or aging. Various methods have been devised to improve the appearance of periorbital dyspigmentation, such as applying concealer and / or other cosmetics to hide its appearance. However, the use of makeup to conceal the appearance of periorbital dyspigmentation is only a temporary solution. In order to maintain the cosmetic benefits provided by conventional cosmetic products, the user will ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/9789A61Q19/00A61Q19/02A61B5/103
CPCA61Q19/005A61Q19/02A61K36/42A61K8/9789A61B5/1032A61B5/444A61K8/062A61K8/97A61K2800/48A61K2800/74A61Q19/00
Inventor K·M·欧索里奥
Owner THE PROCTER & GAMBLE COMPANY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com