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Preparation method of fucus extract

A fucus extract and technology of fucus, applied in the direction of solid solvent extraction, etc., can solve the problems of low content of active ingredients, dark color, complex components, etc., and achieve the effect of increased content and light color

Inactive Publication Date: 2018-12-25
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above problems, the purpose of the present invention is to provide a preparation method of fucus extract, which solves the problems of dark product color, complex components and low content of active ingredients in the prior art.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 100g of fucus powder, add 8 times the volume of fucus weight in petroleum ether, stir and extract for 1 hour, filter to obtain the filter residue, add 10 times the volume of fucus weight in water, stir and extract at 60°C for 1 hour, filter to obtain the filtrate, Let cool to room temperature, use the filtrate as the sample liquid, load the sample into the treated HPD-400 macroporous resin chromatography column at a flow rate of 1 times the column volume / hour, and elute with water at a flow rate of 2 times the volume / hour 1 times the column volume, then eluted 3 times the column volume with 70% ethanol at a flow rate of 2 times the volume / hour, collected the 70% ethanol eluate, concentrated, and dried to obtain 6.0 g of Fucus extract, with a yield of 6%, ink The content of carrageenan is 60% (the determination method is DNS method (3,5-dinitrosalicylic acid method)).

Embodiment 2

[0022] Weigh 200g of fucus powder, add 9 times the volume of fucus weight in petroleum ether, stir and extract for 1.5h, filter to obtain the filter residue, add 12 times the volume of fucus weight in water, extract at 70°C for 1.5h, and filter to obtain the filtrate , let it cool to room temperature, use the filtrate as the sample liquid, load the sample into the treated HPD-200 type macroporous resin chromatography column at a flow rate of 2 times the column volume / hour, and wash with water at a flow rate of 3 times the volume / hour Remove 1 times the column volume, then elute 4 times the column volume with 75% ethanol at a flow rate of 3 times volume / hour, collect the 75% ethanol eluate, concentrate, and dry to obtain 10.0 g of Fucus extract, with a yield of 5% , the fucus polysaccharide content is 62%.

Embodiment 3

[0024] Weigh 300g of Fucus powder, add 10 times the volume of Fucus weight in petroleum ether, stir and extract for 2 hours, filter to obtain the filter residue, add an appropriate amount of water 15 times the weight of Fucus, extract at 80°C for 2 hours, and filter to obtain the filtrate. Allow to cool to room temperature, use the filtrate as the sample solution, load the processed HPD-400 type macroporous resin chromatography column at a flow rate of 3 times the column volume / hour, and first elute with water at a flow rate of 4 times the volume / hour 1 times the column volume, and then eluted with 80% ethanol for 5 times the column volume at a flow rate of 4 times the volume / hour, collected the 80% ethanol eluate, concentrated, and dried to obtain 16.5g of Fucus extract, with a yield of 5.5%. Carrageenan content is 61%.

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PUM

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Abstract

The invention discloses a preparation method of a fucus extract, and belongs to the field of extraction and separation of natural drugs. The method comprises the following specific steps: 1) taking fucus powder, adding a solvent, stirring and filtering to obtain filter residues; 2) adding water in the filter residues, stirring and extracting, filtering to obtain filtrate, and cooling to a room temperature; and 3) adding the filtrate in a macroporous resin chromatographic column, eluting with an aqueous solution at first, then eluting with an alcoholic solution, and collecting an alcoholic solution eluent, and then concentrating and drying the alcoholic solution eluent. The obtained extract product is light in color, and the content of fucus polysaccharide as an effective ingredient is high.

Description

technical field [0001] The invention belongs to the field of extraction and separation of natural medicines, and relates to a preparation method of fucus extract. technical background [0002] Fucus is a brown algae that grows on the rocks on the shore. It grows on the coast of Brittany, France where abundant marine life gathers, and can be harvested at low tide. Its algae are dark brown, bifurcated branches, and flat horn-like leaves. The source of Fucus extract is Fucus in rocky coasts and saline flats in the northern temperate zone. Fucus extract can balance metabolism, improve immune function, supplement minerals, absorb arsenic and form arsenic-containing metallothionein in cells. In addition, it also has good effects in beauty, anti-aging, hair care, etc. Fucus extract can beautify and nourish the skin, and use Fucus extract to make a mask, which can moisturize the skin, whiten and remove freckles, and make the skin refreshing, smooth and smooth. beauty. The combin...

Claims

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Application Information

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IPC IPC(8): B01D11/02
CPCB01D11/02
Inventor 季浩闫成亮阚建伟窦长清孔繁博徐娟
Owner JIANGSU TIANSHENG PHARMA
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