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An anthraquinone compound derived from deep-sea fungi and its application in the preparation of antiallergic drugs

A compound, anthraquinone technology, applied in the field of anthraquinone compounds and their application in the preparation of anti-allergic drugs, can solve the problems of limited types of allergens, achieve good application prospects and promote effective application

Active Publication Date: 2020-02-07
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the types of allergens that can be clearly identified in medicine are currently limited, and allergic reactions to unknown allergens are still hard to prevent.

Method used

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  • An anthraquinone compound derived from deep-sea fungi and its application in the preparation of antiallergic drugs
  • An anthraquinone compound derived from deep-sea fungi and its application in the preparation of antiallergic drugs
  • An anthraquinone compound derived from deep-sea fungi and its application in the preparation of antiallergic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Preparation of anthraquinone compounds

[0024] (1) Aspergillus nidulans (available from the China Marine Microbial Culture Collection and Management Center, preservation number: MCCC 3A00050) was added to 40 1L Erlenmeyer Erlenmeyer flasks containing 80g oats, and incubated at 25°C. Day, add ethyl acetate to extract, degrease with petroleum ether and dichloromethane, and concentrate at low pressure to obtain 100g of crude fermentation extract;

[0025] (2) Separate the crude fermentation extract in step (1) on a silica gel column (49×460mm), and use dichloromethane-methanol gradient elution (CH 2 Cl 2 -MeOH, 100:0→0:100) is divided into 7 fractions (Fr.1–Fr.7);

[0026] (3) The fifth fraction Fr.5 (CH 2 Cl 2 -MeOH, eluted at 20:80) was separated by ODS chromatographic column (26×310mm), and methanol-water solution was used for gradient elution (MeOH-H 2 O, 5:95→100:0), divided into 6 sub-fractions (Fr.5.1–Fr.5.6);

[0027] (4) The sixth subfraction Fr.5.6 (MeOH-H) o...

Embodiment 2 Embodiment 1

[0032] Example 2 In vitro anti-allergic activity test of the compound prepared in Example 1

[0033] Mast cells have not yet obtained good cell lines and cannot be subcultured in vitro, so it is difficult to obtain a large number of cells with uniform characteristics for experimental research. The RBL-2H3 cell line has a similar cell structure and degranulation reaction mechanism to mast cells. More importantly, this cell line can be stably subcultured in vitro, so it is often used as an alternative model of mast cells to study the functions of mast cells. Further applied to the research of allergic diseases.

[0034] In this example, an IgE-mediated RBL-2H3 cell model was selected to detect the degranulation efficiency after cell sensitization, calculate the inhibition rate of the compound on the cell degranulation efficiency, and further calculate the anti-allergic activity of the compound.

[0035] This embodiment is divided into the following 4 groups:

[0036] (1) Negative contr...

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Abstract

The invention discloses an anthraquinone compound from fungi in deep sea and application of the anthraquinone compound in preparation of antiallergic drugs. The structure of the anthraquinone compoundfrom fungi in deep sea is shown in formula (I), and the anthraquinone compound can be used for preparing the antiallergic drugs.

Description

Technical field [0001] The invention belongs to the application field of marine microbial medicines. More specifically, the invention relates to an anthraquinone compound and its application in the preparation of anti-allergic medicines. Background technique [0002] Allergy refers to a reproducible adverse reaction that can affect different organs of the body caused by the immune system's specific immune response to the allergen after a certain substance (such as food, medicine, etc.) enters the human body, which can cause urticaria, nasal congestion and nose Multiple system reactions such as itching, wheezing, nausea and vomiting, and tachycardia. These reactions can be mild local reactions or serious life-threatening reactions. [0003] Allergy is a global health problem, with millions of patients. Epidemiological research results show that the prevalence of allergies has been increasing in the past 20 years, and the current recommended allergy treatment methods are still stri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A61K31/343A61P37/08C12P17/18C12R1/66
CPCA61P37/08C07D493/04C12P17/181
Inventor 杨献文邢翠平夏金梅
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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