Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Tongguan Capsules in Preparation of Drugs for Treating Hypertensive Heart Failure

A technology for heart failure and hypertension, applied in the field of traditional Chinese medicine, to achieve the effects of increasing cardiac systolic function, delaying ventricular remodeling, and determining and reliable curative effect

Active Publication Date: 2021-09-21
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug for the treatment of coronary heart disease provided by this patent acts on multiple targets of atherosclerosis and restenosis, such as vascular smooth muscle cells, endothelial cells, platelets, coagulation-fibrinolytic system, blood lipids, and inflammatory factors. Effective treatment and overall adjustment for patients after intervention, but there is no report on the use of Tongguan Capsules in the treatment of hypertensive heart failure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Tongguan Capsules in Preparation of Drugs for Treating Hypertensive Heart Failure
  • Application of Tongguan Capsules in Preparation of Drugs for Treating Hypertensive Heart Failure
  • Application of Tongguan Capsules in Preparation of Drugs for Treating Hypertensive Heart Failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Tongguan Capsules are used to prepare the medicine for treating hypertensive heart failure, and the preparation method is as follows:

[0055] (1) take by weighing raw material Radix Astragali, Salvia Miltiorrhiza, and leech respectively, and the percentage by weight of the three is: Radix Astragali: Salvia Miltiorrhiza: Leech=50%: 35%: 15%;

[0056] (2) cleaning, drying and pulverizing the salvia miltiorrhiza and the leech, and passing through a 120-mesh sieve to obtain the salvia miltiorrhiza-leech powder;

[0057] (3) Add 10 times the amount of water to Astragalus each time, decoct three times, boil for 1h, 45min and 45min each time, pass through a 60-mesh filter cloth while it is hot, combine the filtrate three times, concentrate until the water content is ≤ 8%, and let it cool to room temperature, slowly add ethanol with a volume ratio of 60%, refrigerate and stand for 24h-48h, filter, concentrate to 20°C when the relative density is 1.10-1.20, recover ethanol, and...

Embodiment 2

[0060] Tongguan Capsules are used to prepare the medicine for treating hypertensive heart failure, and the preparation method is as follows:

[0061] (1) take raw material medicine Radix Astragali, Salvia Miltiorrhiza, and leech respectively, and the percentage by weight of the three is: Radix Astragali: Salvia Miltiorrhiza: Leech=60%: 20%: 20%;

[0062] (2) Mix astragalus and salvia miltiorrhiza with 10 times the amount of water each time, decoct three times, boil for 1h, 45min and 45min each time, pass through a 60-mesh filter cloth while it is hot, combine the filtrates three times, and concentrate until the water content is ≤8% , let cool to room temperature, slowly add ethanol with a volume ratio of 60%, refrigerate and stand for 24h-48h, filter, concentrate to 20°C when the relative density is 1.10-1.20, recover ethanol, and obtain Radix Astragali-Salvia miltiorrhiza extract;

[0063] (3) leeches are washed, dried, pulverized, and passed through a 120-mesh sieve to obtai...

Embodiment 3

[0066] Tongguan Capsules are used to prepare the medicine for treating hypertensive heart failure, and the preparation method is as follows:

[0067] (1) take by weighing raw material Astragalus membranaceus, Salvia miltiorrhiza, and leech respectively, and the percentage by weight of the three is: Astragalus: Salvia miltiorrhiza: Leech=40%: 50%: 10%;

[0068] (2) Heat and reflux ethanol with 7 times of Danshen root for 1.5h, filter, add ethanol with a volume ratio of 50% of the filtrate to the dregs, heat and reflux for 1h, filter, combine the filtrates, and when concentrated to 20°C, the relative density is 1.10 to 1.20, Recover ethanol to obtain salvia miltiorrhiza extract;

[0069] (3) Add Astragalus membranaceus to the dregs of Salvia miltiorrhiza, add 10 times the amount of water each time, decoct three times, boil for 1h, 45min and 45min each time, pass through a 60-mesh filter cloth while it is hot, combine the three filtrates, and concentrate the filtrate under reduce...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the field of medicine, in particular to the new application of Tongguan Capsules, in particular to the application in the preparation of drugs for hypertensive heart failure, wherein the main active ingredient of Tongguan Capsules consists of the following raw materials by weight percentage: Astragalus membranaceus 40-60 %, Danshen 20-50%, leeches 5-25%. Experiments have proved that the Tongguan Capsules of the present invention have good therapeutic and alleviating effects in improving ventricular hypertrophy, increasing cardiac systolic function, delaying ventricular remodeling, and treating and improving hypertensive heart failure, and its therapeutic effect is better than that of the United States. Moreover, the Tongguan Capsule of the present invention has less medicinal taste, reliable curative effect, clear medicinal components and fewer adverse reactions, and can significantly improve the patient's prognosis and quality of life.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the application of Tongguan capsules in the preparation of medicines for treating hypertension and heart failure. Background technique [0002] If high blood pressure is poorly controlled for a long time, it can cause changes in the structure and function of the heart, which is called hypertensive heart disease, including: early left ventricular diastolic dysfunction, left ventricular hypertrophy, and gradual development of myocardial systolic dysfunction eventually leading to heart failure. Studies have shown that 70% of heart failure is caused by high blood pressure. At present, the mechanism of heart failure caused by hypertension is not completely clear. The basic mechanism leading to the occurrence and development of heart failure is myocardial remodeling. Prevention and treatment of congestive heart failure[J]. China Medical Journal, 2012,47(7):6-9.). Under the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/12A61P9/04A61K35/62
CPCA61K35/62A61K36/481A61K36/537A61P9/04A61P9/12A61K2300/00
Inventor 祁建勇谭亚芳张敏州潘文君
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com