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Multifunctional composite sponge with effects of easing pain, stopping bleeding, disinfecting and sterilizing and preparation method of multifunctional composite sponge

A sterilization, compound technology, applied in pharmaceutical formulations, surgical adhesives, applications, etc., can solve the problems of low functional effect compound degree, poor biocompatibility of sponge substrates, complicated preparation of raw materials, etc., and achieve long-term stability. Anesthesia and analgesia, isolation and protection of drug concentration, significant blood sucking and hemostasis effect

Inactive Publication Date: 2018-12-28
SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of complex preparation of raw materials, low degree of functional effect compounding, and poor biocompatibility of the sponge base material in the existing medical sponge, and to provide a long-term, stable analgesic, hemostasis, and multiple compound functions of sterilization and disinfection. , and good biocompatibility, safe and convenient new medical sponge product and preparation method thereof

Method used

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  • Multifunctional composite sponge with effects of easing pain, stopping bleeding, disinfecting and sterilizing and preparation method of multifunctional composite sponge
  • Multifunctional composite sponge with effects of easing pain, stopping bleeding, disinfecting and sterilizing and preparation method of multifunctional composite sponge

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Preparation of sponge matrix material

[0041] S1. Chitosan pretreatment: First, convert chitosan into water-soluble hydroxypropyl chitosan through functional group substitution reaction, and then use amidation reaction to replace the free amino groups in water-soluble propyl chitosan to obtain acryloyl chitosan Hydroxypropyl chitosan; Specifically comprise the steps:

[0042] S1a. According to the solid-to-liquid ratio of 3:20, mix chitosan and isopropanol solution, stir for 3h, add 4mL of 30% sodium hydroxide aqueous solution and continue stirring for 5-6h, freeze overnight at -20°C, thaw, Add 25mL of propylene oxide and 4mL of 10% tetramethylammonium hydroxide as a catalyst, slowly heat up to 60°C, continue the reaction for 8h, and filter to obtain water-soluble hydroxypropyl chitosan;

[0043] S1b. After dissolving the prepared hydroxypropyl chitosan in water according to the solid-to-liquid ratio of 1:20, add β-(acryloyloxy)propionic acid and the same molar am...

Embodiment 2

[0056] (1) Preparation of sponge matrix material

[0057] S1. Chitosan pretreatment: First, convert chitosan into water-soluble hydroxypropyl chitosan through functional group substitution reaction, and then use amidation reaction to replace the free amino groups in water-soluble propyl chitosan to obtain acryloyl chitosan Hydroxypropyl chitosan; Specifically comprise the steps:

[0058] S1a. According to the solid-to-liquid ratio of 5:80, mix chitosan and isopropanol solution, stir for 5h, add 4mL of 30% sodium hydroxide aqueous solution and continue stirring for 5-6h, freeze overnight at -20°C, thaw, Add 10-25mL of propylene oxide and 4mL of 10% tetramethylammonium hydroxide as a catalyst, slowly raise the temperature to 60°C, continue the reaction for 8 hours, and filter to obtain water-soluble hydroxypropyl chitosan;

[0059] S1b. After dissolving the prepared hydroxypropyl chitosan in water according to the solid-to-liquid ratio of 1:20, add β-(acryloyloxy)propionic acid...

Embodiment 3

[0072] (1) Preparation of sponge matrix material

[0073] S1. Chitosan pretreatment: First, convert chitosan into water-soluble hydroxypropyl chitosan through functional group substitution reaction, and then use amidation reaction to replace the free amino groups in water-soluble propyl chitosan to obtain acryloyl chitosan Hydroxypropyl chitosan; Specifically comprise the steps:

[0074] S1a. According to the solid-to-liquid ratio of 1:20, mix chitosan and isopropanol solution, stir for 2-5h, add 2mL of 30% sodium hydroxide aqueous solution and continue stirring for 5-6h, freeze overnight at -20°C, Thaw, add 10-25mL of propylene oxide and 2mL of 10% tetramethylammonium hydroxide as a catalyst, slowly raise the temperature to 60°C, continue the reaction for 8 hours, and filter to obtain water-soluble hydroxypropyl chitosan;

[0075] S1b. After dissolving the prepared hydroxypropyl chitosan in water according to the solid-to-liquid ratio of 1:20, add β-(acryloyloxy)propionic ac...

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Abstract

The invention discloses a multifunctional composite sponge with effects of easing pain, stopping bleeding, disinfecting and sterilizing. The multifunctional composite sponge is mainly composed of a sponge matrix material and a local anesthetic, wherein the sponge matrix material is chitosan / polyethylene glycol modified three-dimensional porous gel; the local anesthetic is tetracaine hydrochlorideentrapped by a bletilla striata polysaccharide amphiphilic polymer shell. The multifunctional composite sponge is prepared by the following steps: taking the sponge matrix material as a drug-loading substrate, taking the local anesthetic as a loaded drug, and loading according to a weight part ratio of (4-9):(91-96). The sponge has multiple composite functions of stably easing pain and stopping bleeding in a long-acting manner as well as sterilizing and disinfecting, is excellent in biocompatibility, safe and convenient to use and high in comfort, and is a multifunctional composite sponge withhigh medical value and practical value.

Description

technical field [0001] The invention relates to the field of new medical materials, in particular to a multifunctional composite sponge capable of analgesia, hemostasis, disinfection and sterilization. Background technique [0002] Anesthesia refers to the state that allows patients to undergo surgery or invasive procedures without pain and discomfort. It is generally believed that anesthesia is a kind of reversible functional inhibition of the central nervous system and (or) peripheral nervous system produced by drugs or other methods. The main feature of this inhibition is the loss of sensation, especially pain sensation. However, surgical anesthesia also has a validity period. After the operation is completed, when the anesthesia carried out before the operation fails, the patient will feel pain. The traditional method of relieving pain is to take or inject painkillers to the patient, but these drugs have a certain degree of side effects, and are prone to addiction, caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L24/08A61L24/04A61L24/00
CPCA61L26/0052A61L24/0015A61L24/0036A61L24/043A61L24/08A61L26/0023A61L26/0066A61L26/0085A61L2300/216A61L2300/232A61L2300/402A61L2300/404A61L2300/418A61L2300/62A61L2400/04C08L5/08C08L71/02C08L5/00
Inventor 舒春柳洪艳
Owner SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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