Electrochemical sensor based on iron phthalocyanine/nitrogen and boron doped reduction graphene oxide, and preparation method and application thereof

A boron doping, graphene technology, applied in scientific instruments, instruments, material analysis by electromagnetic means, etc., can solve the problems of expensive detection, limited selectivity, low sensitivity, etc., and achieve good stability and reproducibility , improved catalysis, ease of functionalization and production

Active Publication Date: 2018-12-28
SHANXI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Various analytical methods have been developed to determine glutathione, such as high-performance liquid chromatography, gas chromato...

Method used

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  • Electrochemical sensor based on iron phthalocyanine/nitrogen and boron doped reduction graphene oxide, and preparation method and application thereof
  • Electrochemical sensor based on iron phthalocyanine/nitrogen and boron doped reduction graphene oxide, and preparation method and application thereof
  • Electrochemical sensor based on iron phthalocyanine/nitrogen and boron doped reduction graphene oxide, and preparation method and application thereof

Examples

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Embodiment 1

[0017] Embodiment 1: An electrochemical sensor based on iron phthalocyanine / nitrogen and boron doped reduced graphene oxide, the specific preparation method is:

[0018] (1) Preparation of nitrogen and boron doped reduced graphene oxide N,B-rGO by hydrothermal method: 25 mg of GO was dispersed in 50 mL of water with the assistance of ultrasonic waves to form a uniform GO suspension with a concentration of 0.5 mg / mL, and dilute Ammonia water (5% mole fraction) was used to adjust the pH of the suspension to 8.0, and 2.0 g of urea and 100 mg of boric acid were added to the suspension under vigorous stirring; the mixture was stirred at room temperature for 30 min, and transferred to a Teflon-lined Put in the reaction kettle for 12 hours, then cool in the air, collect the N,B-rGO complex by centrifugation (12000 rpm), wash repeatedly with water and ethanol, and dry under vacuum at 60°C to obtain the N,B-rGO complex;

[0019] (2) Preparation of iron phthalocyanine / nitrogen, boron do...

Embodiment 2

[0020] Example 2: An electrochemical sensor based on iron phthalocyanine / nitrogen and boron doped reduced graphene oxide. The specific preparation method is: dissolving iron phthalocyanine FePc in secondary water, and ultrasonically dissolving it for 20 minutes at a frequency of 40 KHz , to make iron phthalocyanine solution with a concentration of 5.0mM, add 2.0 mg of nitrogen and boron doped reduced graphene oxide N,B-rGO to the solution, and ultrasonicate at 40 KHz for 20min to form a dispersed concentration of 2 mg / mL Then, 10.0 μL of the dispersion liquid was drop-coated on the glassy carbon electrode, dried under the infrared lamp for 20 min, and finally washed with secondary water to remove the loosely adsorbed nanocomposites to obtain iron phthalocyanine / nitrogen and boron doped reduction oxidation Graphene FePc / N, B-rGO modified electrode. All the other preparation methods are the same as those described in Example 1.

Embodiment 3

[0021] Example 3: An electrochemical sensor based on iron phthalocyanine / nitrogen and boron doped reduced graphene oxide. The specific preparation method is: dissolve iron phthalocyanine FePc in secondary water, and fully dissolve it by ultrasonication at a frequency of 40 KHz for 10 minutes , to make iron phthalocyanine solution with a concentration of 0.5mM, add 0.2 mg nitrogen and boron doped reduced graphene oxide N,B-rGO to the solution, and ultrasonicate at 40 KHz for 10min to form a dispersed concentration of 0.2 mg / mL solution, and then 4.0 μL of dispersion liquid was drop-coated on the glassy carbon electrode, dried under infrared lamp for 5 min, and finally rinsed with secondary water to remove the loosely adsorbed nanocomposites, and obtained iron phthalocyanine / nitrogen, boron doped reduction oxidation Graphene FePc / N, B-rGO modified electrode. All the other preparation methods are the same as those described in Example 1.

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Abstract

The invention belongs to the technical field of preparation of electrochemical electrode materials, and provides an electrochemical sensor based on iron phthalocyanine/nitrogen and boron doped reduction graphene oxide, and a preparation method and an application thereof. The electrochemical sensor is based on a composite material of the iron phthalocyanine/nitrogen and the boron doped reduction graphene oxide(FePc/N, B-rGO) and is prepared by modifying the surface of a glassy carbon electrode by using the composite material, the sensitivity and selectivity are high, the electrode modificationprocess modification process is simpler, and the stability and reproducibility are good. The sensor can be applied to detect glutathione in human serum. The sensor prepared by the method can be used for the detection of the glutathione. The sensor has the characteristics of high sensitivity and selectivity, rapid response, good stability and reproducibility and large detection range, and can be applied to the detection of the glutathione in human serum.

Description

technical field [0001] The invention belongs to the technical field of preparation of electrochemical electrode materials, in particular to an electrochemical sensor based on iron phthalocyanine / nitrogen and boron doped reduced graphene oxide and a preparation method thereof, and the prepared sensor can detect glutathione in human serum Peptide application. Background technique [0002] Reduced glutathione (GSH) plays vital roles in the human body, including redox balance, cell growth and catabolism. As the main component of extracellular thiols found in mammals, it plays an integral role in the maintenance of protein structure, and also acts as an anticancer agent, radioprotectant, antitoxin, antioxidant and free radical in the body Scavengers of cancer. Abnormal levels of GSH are directly linked to slow growth in children, damage to cells and organs, and even diseases such as cancer, AIDS, Alzheimer's, diabetes, and cardiovascular diseases. Therefore, it is of great pra...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/308G01N27/3277
Inventor 雷鹏周影洪沙沙杨亚娟双少敏
Owner SHANXI UNIV
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