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Preparation method of high-quality natural borneol (d-borneol) without camphor

A technology of natural borneol and d-borneol, which is applied in the field of medicine, can solve the problems of high cost and residue, and achieve the effects of low cost, low energy consumption and fast distillation speed

Inactive Publication Date: 2019-01-01
欧晓英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology does not solve the problem that the product contains camphor, and it needs to be refined with organic solvents or other chemical components, and there are residues of organic solvents or other chemical components, and the cost is relatively high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 500kg of fresh branches and leaves of camphor, cut them into 10-20cm sections, put them in a multifunctional extraction tank, add about 2000L of water, close the valve, open the vacuum to remove the air in the tank, and keep the pressure range of -0.04~-0.06MPa in the tank , heated to boiling with steam, distilled at 65-80°C for 2 hours, collected the crude product crystals and volatile oil in the oil-water separator, and centrifuged to obtain 9.6kg of crude product and 4.5kg of volatile oil. According to the ratio of 1.5kg volatile oil per 1kg crude product, put the crude product and volatile oil into the dissolving tank, heat and stir until they are completely dissolved, filter to remove impurities and residual moisture, and store the hot volatile oil solution in a sealed airtight place. After cooling to room temperature, put - Stand airtight and store at 18°C ​​for 2 days, filter out the volatile oil, crystallize and dry in vacuum at low temperature to obtain 8.6...

Embodiment 2

[0019] Take 500kg of fresh branches and leaves of Cinnamomum camphora, put it in a multifunctional extraction tank, close the valve, open the vacuum to remove the air in the tank, keep the pressure in the tank in the range of -0.01-0.02MPa, feed steam, and distill at 85-95°C Extract for 3 hours, collect the crude product crystals and volatile oil in the oil-water separator, and centrifuge to obtain 9.2 kg of crude product and 4.5 kg of volatile oil. According to the ratio of 2kg volatile oil per 1kg crude product, put the crude product and volatile oil into the dissolving tank, vacuumize to -0.09MPa to remove the air in the tank, turn off the vacuum, heat and stir until completely dissolved, filter to remove impurities and residual moisture, and volatile oil hot solution Put it in airtight storage, after cooling to room temperature, filter out the volatile oil, crystallize and dry in a low-temperature vacuum to obtain 7.9kg of natural borneol, no camphor is detected by gas chro...

Embodiment 3

[0021] Take 100kg of fresh branches and leaves of Cinnamomum camphora, put it in a multi-functional extraction tank, close the valve, open the vacuum valve to extract the air in the extraction tank, keep the pressure range of -0.05~-0.08MPa in the tank, heat with direct steam, 50~80℃ Distill and extract for 3 hours, collect the crude product crystals and volatile oil in the oil-water separator, and centrifuge to obtain 2.1 kg of crude product and 0.8 kg of volatile oil. The crude product was purified to obtain 1.5 kg of natural borneol, which did not contain camphor as detected by gas chromatography.

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Abstract

The invention relates to a preparation method of high-quality natural borneol (d-borneol) without camphor, and relates to the technical field of a medicine, in particular to the preparation method ofhigh-quality natural borneol (d-borneol) without camphor. In view of the fact that the products in the prior art contain camphor, organic solvents or other chemical residues, and the cost is high, Themethod adopts extraction by vacuum distillation, reduces the extraction temperature, reduces the contact with oxygen, reduces the loss of active ingredients, and improves the efficiency and reduces the cost; the volatile oil (essential oil) obtained by distillation extraction is employed for dissolving crystals, and the obtained product has zero organic solvent and other chemical component residue, the content of the d-borneol is more than 98.5%, the high-quality natural borneol does not contain camphor through detection by a gas chromatographic method, and the yield of the product is increased by more than 15%. The product quality and price competitiveness are strong.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of high-quality natural borneol (d-borneol) without camphor. Background technique [0002] Natural borneol, commonly known as "plum borneol", "plum slice", "plum blossom brain", "borneol incense", etc., has the effects of resuscitating the mind, clearing away heat and relieving pain, and is an essential medicine for aromatic resuscitation. It is necessary to cooperate with each other, so that the power of fragrance to open up and refresh the mind is greatly increased. It is a commonly used antidote for stroke, high fever, coma and other closed diseases. It is called "ice musk deer" in the world. [0003] Natural borneol is native to the Sumatra Islands in Indonesia. It is extracted from the resin of the dipterocarp tree Dryobalanops aromatica Gaertn. f., or sublimated from the trunk and branches of dipterocarp through steam distillation. Dipterocarp is main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/76C07C29/80C07C29/78C07C35/30
CPCC07B2200/07C07C29/76C07C29/78C07C29/80C07C35/30
Inventor 吴发强
Owner 欧晓英
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