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Preparation method of microfluidic chip

A microfluidic chip and substrate technology, applied in the field of micro-droplets, can solve the problems of low bonding strength between the coating and the surface of the microfluidic chip, uneven coating, cumbersome operation, etc., and achieve good optical properties and preparation technology The effect of simplicity and simplification of operation steps

Active Publication Date: 2019-01-08
DELIN ENVIRONMENTAL PROTECTION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the technologies for changing the surface wetting properties of microfluidic chip channels use surface coating methods or add surfactants to the treatment targets. On the one hand, special instruments and equipment are required, the operation is cumbersome, and the cost is high. Inhomogeneous coating and low bonding strength between the coating and the surface of the microfluidic chip
However, the method of using surface coating and introducing surfactant to change the wettability of the microfluidic chip channel requires the introduction of chemical reagents, which has the problem of reagent contamination and interference for subsequent applications.

Method used

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  • Preparation method of microfluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Such as figure 1 As shown, the present invention adopts the microfluidic chip preparation process modified by carbon nanomaterials:

[0034] (1) Weighing: Weigh the PDMS precursor and curing agent with a mass ratio of 10:1 in a beaker, and stir evenly with a glass rod.

[0035] (2) Add carbon nanomaterials: add graphene into the beaker in step (1) to make the content 0.005wt%, and stir evenly.

[0036] (3) Degassing: Put the beaker in step (2) into a vacuum drying oven, turn on the vacuum pump, so that the PDMS in the beaker does not overflow, until the air in the PDMS is exhausted.

[0037] (4) Pouring: Take out the PDMS liquid in step (3) and pour it on the chip male mold. In order to prevent the PDMS liquid from flowing out, place the chip male mold in a container with grooves in advance. When pouring, pay attention to pouring from the middle to the surrounding to avoid air bubbles.

[0038] (5) Curing: Put the container in step (4) into a 40°C oven and heat for 2...

Embodiment 2

[0073] Such as figure 1 As shown, the present invention adopts the microfluidic chip preparation process modified by carbon nanomaterials:

[0074] (1) Weighing: Weigh the PDMS precursor and curing agent with a mass ratio of 10:1 in a beaker, and stir evenly with a glass rod.

[0075] (2) Add carbon nanomaterials: add carbon nanotubes, graphene and carbon quantum dots to the beaker in step (1) so that the content is 0.005wt%, and stir evenly.

[0076] (3) Degassing: Put the beaker in step (2) into a vacuum drying oven, turn on the vacuum pump, so that the PDMS in the beaker does not overflow, until the air in the PDMS is exhausted.

[0077] (4) Pouring: Take out the PDMS liquid in step (3) and pour it on the chip male mold. In order to prevent the PDMS liquid from flowing out, place the chip male mold in a container with grooves in advance. When pouring, pay attention to pouring from the middle to the surrounding to avoid air bubbles.

[0078] (5) Curing: Put the container ...

Embodiment 3

[0083] Such as figure 1 As shown, the present invention adopts the microfluidic chip preparation process modified by carbon nanomaterials:

[0084] (1) Weighing: Weigh the PDMS precursor and curing agent with a mass ratio of 10:1 in a beaker, and stir evenly with a glass rod.

[0085] (2) Add carbon nanomaterials: add carbon quantum to the beaker in step (1) to make the content 0.1wt%, and stir evenly.

[0086] (3) Degassing: Put the beaker in step (2) into a vacuum drying oven, turn on the vacuum pump, so that the PDMS in the beaker does not overflow, until the air in the PDMS is exhausted.

[0087] (4) Pouring: Take out the PDMS liquid in step (3) and pour it on the chip male mold. In order to prevent the PDMS liquid from flowing out, place the chip male mold in a container with grooves in advance. When pouring, pay attention to pouring from the middle to the surrounding to avoid air bubbles.

[0088] (5) Curing: Put the container in step (4) into a 90°C oven and heat it ...

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Abstract

The invention discloses a preparation method of a microfluidic chip. The microfluidic chip is prepared by adding a carbon nano material before a substrate and a cover are formed and carrying out bonding. According to the preparation method, the carbon nano material and a macromolecular microfluidic chip are mixed into a whole by adding the carbon nano material into a raw material before the substrate and the cover are formed, so that the bonding strength is high, and the surface microstructure of the microfluidic chip and the surface functional property of the microfluidic chip are greatly changed. The carbon nano material is extremely high in hydrophobicity and extremely large in specific surface area, so that when water is used as a dispersing phase, the adding of the carbon nano material is more favorable for the formation of liquid drops.

Description

technical field [0001] The invention relates to the technical field of micro-droplets, in particular to a preparation process of a microfluidic chip that is easy to generate droplets. Background technique [0002] As an important branch of microfluidic chip technology, micro-droplet technology relies on the immiscible nature of two solutions in micro-scale channels. Using one of the solutions as the dispersed phase and the other solution as the continuous phase, combined with the microfluidic chip material, the structure of the microfluidic chip channel and the manipulation of external forces, the interaction between the flow shear force and the surface tension is used A micro-nano technology in which the continuous phase shears the dispersed phase into tiny droplets of nanoliter volume and below. [0003] The core and primary step of micro-droplet technology is the generation of micro-droplets, so making a microfluidic chip that is conducive to the generation of micro-drop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/502707B01L2200/10B01L2300/0861B01L2300/0887B01L2300/12B01L2300/165
Inventor 赵阳王丽平洪樱伦
Owner DELIN ENVIRONMENTAL PROTECTION TECH