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Preparation method of silicon dioxide with high bulk density

A silicon dioxide and bulk density technology, applied in chemical instruments and methods, inorganic chemistry, silicon compounds, etc., can solve the problems of large product performance differences and insufficient fine control of product bulk density indicators, and achieve low cost and easy product filling. Simple installation and operation

Active Publication Date: 2019-01-11
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are many manufacturers of this product in China, but the control of the bulk density index of the product is not fine enough, and the bulk density causes great differences in product performance. The bulk density of domestic products is generally 0.1g / mL~0.2g / mL

Method used

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  • Preparation method of silicon dioxide with high bulk density

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Embodiment 1

[0025] A preparation method of high bulk density silicon dioxide, comprising the following steps:

[0026] S1. Put sodium silicate with a modulus of 2.2 and purified water into the autoclave for dissolution, and prepare Na 2 O calculation, concentration is the sodium silicate aqueous solution A of 1.99mol / L;

[0027] S2. In the synthesis reaction kettle, mix 700L of sodium silicate aqueous solution A and 10000L of purified water in step S1 to obtain sodium silicate aqueous solution B with a concentration of 0.13mol / L, control the reaction temperature to 40°C, and add surfactant 10 Dialkyl sodium sulfate 4.28kg, open the stirring paddle, stir for 10 minutes, add dilute sulfuric acid in the reaction kettle through the rotameter, the flow rate of dilute sulfuric acid is 13L / min, the concentration of dilute sulfuric acid is 2mol / L, drop dilute sulfuric acid to The pH of the reaction system is 6.4-6.8, the time for adding dilute sulfuric acid is 60 minutes, and then standing and a...

Embodiment 2

[0031] A preparation method of high bulk density silicon dioxide, comprising the following steps:

[0032] S1. Put sodium silicate sodium silicate with a modulus of 2.4 and purified water into the autoclave for dissolution, and prepare Na 2 O calculation, concentration is the sodium silicate aqueous solution A of 2.15mol / L;

[0033] S2. In the synthesis reaction kettle, mix 700L of sodium silicate aqueous solution A and 10000L of purified water in step S1 to obtain sodium silicate aqueous solution B with a concentration of 0.14mol / L, control the reaction temperature at 38°C, and add surfactant 10 Dialkyl sodium sulfate 4.82kg, open the stirring paddle, stir for 10 minutes, add dilute sulfuric acid in the reaction kettle through the rotameter, the flow rate of dilute sulfuric acid is 13L / min, the concentration of dilute sulfuric acid is 2mol / L, drop dilute sulfuric acid to The pH of the reaction system is 6.4-6.8, the time for adding dilute sulfuric acid is 60 minutes, and the...

Embodiment 3

[0037] A preparation method of high bulk density silicon dioxide, comprising the following steps:

[0038] S1. Put sodium silicate with a modulus of 2.6 and purified water into the autoclave for dissolution, and prepare Na 2 O calculation, concentration is the sodium silicate aqueous solution A of 2.29mol / L;

[0039] S2. In the synthesis reaction kettle, mix 700L of sodium silicate aqueous solution A and 10000L of purified water in step S1 to obtain sodium silicate aqueous solution B with a concentration of 0.15mol / L, control the reaction temperature at 42°C, and add surfactant 10 Dialkyl sodium sulfate 5.35kg, open the stirring paddle, stir for 10 minutes, add dilute sulfuric acid in the reactor through the rotameter, the flow rate of dilute sulfuric acid is 13L / min, the concentration of dilute sulfuric acid is 2mol / L, drop dilute sulfuric acid to The pH of the reaction system is 6.4-6.8, the time for adding dilute sulfuric acid is 60 minutes, and then standing and aging for 3...

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Abstract

The invention provides a preparation method of silicon dioxide with high bulk density, wherein the preparation method includes the following steps: preparing a uniform sodium silicate aqueous solutionby a high temperature and high pressure method, then preparing a silicon dioxide crystal seed by a diluted sodium silicate aqueous solution, a surfactant and dilute sulfuric acid, and then preparingthe silicon dioxide with high bulk density further by using the sodium silicate aqueous solution and dilute sulfuric acid on the basis of the obtained crystal seed. The bulk density of the silicon dioxide prepared by the method is in a range of 0.4 g / mL-0.6 g / mL, the fluidity of the silicon dioxide is better and the particle size is larger; the silicon dioxide can be mixed more evenly with other raw and auxiliary materials with high bulk density in medicines, especially suspensions and capsules, the uniformity and fluidity of the product can be greatly improved, product filling is facilitatedand the product quality is increased.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical excipients, and in particular relates to a preparation method of high bulk density silicon dioxide. Background technique [0002] In the manufacture of pharmaceuticals, silicon dioxide is mainly used as a disintegrant, anti-sticking agent, and glidant, and has been widely used in the production of solid preparations. It can greatly improve the fluidity of granules, increase the bulk density, increase the hardness of the prepared tablet, shorten the disintegration time limit, and increase the dissolution rate of the drug. It can be used as an internal desiccant in the manufacture of granules to enhance the stability of the drug. It can be used as a suspending agent and thickening agent in liquid preparations, and has similar uses in the food industry. There are many manufacturers of this product in China, but the control of the bulk density index of the product is not fine e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/193
CPCC01B33/193C01P2006/10
Inventor 赵志柱邵云鹤毕勇许宁
Owner ANHUI SUNHERE PHARMA EXCIPIENTS
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