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A strain of Pediococcus lactis and its application in anti-atherosclerosis
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A technology of atherosclerosis and Pediococcus lactis, applied in the direction of application, medical preparations containing active ingredients, bacteria, etc., can solve problems such as localized adverse reactions
Active Publication Date: 2021-09-03
JILIN ACAD OF AGRI SCI
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Problems solved by technology
At present, lipid-lowering therapy is a routine method to prevent and treat atherosclerosis, but the commonly used lipid-lowering drugs have certain limitations and adverse reactions because they are chemically synthesized drugs.
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Embodiment 1
[0101] Embodiment 1, isolation, identification and preservation of bacterial strains
[0102] 1. Isolation of strains
[0103] In May 2017, samples were taken from the West Market in Yanji City, Jilin Province, and the samples taken were traditional farmhouse miso.
[0104] The samples were streaked repeatedly on the solid M17 medium plate, and the single colony that produced the yellow circle was picked and inoculated on the solid M17 medium plate to continue the culture, and then repeatedly streaked and purified on the solid M17 medium plate to obtain multiple pure culture strains .
[0105] The purely cultured strains were inoculated into liquid M17 medium for culture, then added with 20% glycerol, and stored in a -80°C refrigerator.
[0106] Select strains that meet all of the following conditions from purely cultured strains: Gramstain positive, catalase test negative, indole test negative, hydrogensulfide production test negative, gelatinliquefaction test negative, ...
Embodiment 2
[0116] Example 2, the improving effect of Pediococcus lactis AS185 on atherosclerotic rats
[0117] 1. Preparation of bacterial suspension
[0118] The preparation method of the bacterial suspension: suspend the tested bacteria with PBS buffer, so that the bacterial concentration is 1.0×10 9 CFU / ml.
[0119] The tested bacteria were Pediococcus lactis AS185, Pediococcus lactis AS187 or Pediococcus lactis AS189.
[0120] When the test bacteria is Pediococcus lactis AS185, the obtained bacterial suspension is named AS185 bacterial suspension.
[0121] When the test bacteria is Pediococcus lactis AS187, the obtained bacterial suspension is named AS187 bacterial suspension.
[0122] When the test bacteria is Pediococcus lactis AS189, the obtained bacterial suspension is named AS189 bacterial suspension.
[0124] 50 male SD rats were randomly divided into 5 groups, 10 in each group, and the grouping was handled as follows:
[0125]Blank group: f...
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Abstract
The invention discloses a strain of Pediococcus lactis and its application in anti-atherosclerosis. The Pediococcus lactis AS185 provided by the present invention has a deposit registration number of CCTCC NO: M 2018114. The invention also protects the application of Pediococcus lactis AS185 in the preparation of anti-atherosclerotic products. The invention also protects an anti-atherosclerosis product, the active ingredient of which is Pediococcus lactis AS185. The Pediococcus lactis AS185 provided by the present invention prevents and treats atherosclerosis by regulating blood lipids, inhibiting the levels of adhesion molecules and inflammatory factors, and is a new probiotic strain with potential application prospects in the field of cardiovascular disease prevention and treatment.
Description
technical field [0001] The invention relates to a strain of Pediococcus lactis and its application in anti-atherosclerosis. Background technique [0002] Atherosclerosis (AS) is the most common and most important of a group of arteriosclerotic vascular diseases, and is the main cause of coronary heart disease, myocardial infarction, cerebral infarction, and peripheralvascular disease. Dyslipidemia is the most important risk factor for atherosclerosis. At present, lipid-lowering therapy is a routine method to prevent and treat atherosclerosis, but commonly used lipid-lowering drugs have certain limitations and adverse reactions because they are chemically synthesized drugs. Therefore, it is of great significance to screen out safe and reliable active ingredients with lipid-lowering / cholesterol-lowering effects from natural food resources for the prevention and treatment of atherosclerosis. [0003] Pediococcus acidilactici (Pediococcus acidilactici) is a facultative anaero...
Claims
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