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Integrated composite multilayer anti-adhesion hemostatic sponge and preparation method thereof

A hemostatic sponge and anti-adhesion technology, which is applied in the fields of pharmaceutical formulations, surgical adhesives, applications, etc., can solve the problems of sponge anti-adhesion dependence, unfavorable sponge biocompatibility, and insufficient hemostatic effect, so as to avoid secondary Infection, good anti-adhesion effect, hemostasis, sterilization and anti-infection effect, long-lasting effect

Inactive Publication Date: 2019-01-18
SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as the existing hemostatic sponge is concerned, the hemostatic effect is slow to take effect, the hemostatic effect is not long enough, and the anti-adhesion effect of the sponge depends on the use of additives such as vaseline and paraffin oil, which is not conducive to the biocompatibility of the sponge itself

Method used

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  • Integrated composite multilayer anti-adhesion hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Such as figure 1 As shown, the integrated composite multi-layer anti-adhesion hemostatic sponge includes an upper surface woven protective layer 1 with a thickness of 0.5 mm, a middle porous hemostatic gel layer 2 with a thickness of 0.2 mm, and a porous lower surface with a thickness of 0.1 mm. Gel woven composite layer 3; the upper surface woven protective layer 1, the middle porous hemostatic gel layer 2 and the lower surface porous hemostatic gel woven composite layer 3 are laminated sequentially from top to bottom, and the two adjacent layers An integrated composite multilayer structure formed by cross-linking of hemostatic gel.

[0042] The upper surface woven protective layer 1 is a mesh fabric with a density of 90% woven from chitosan fibers and / or Bletilla striata polysaccharide fibers.

[0043] The middle porous hemostatic gel layer 2 is a chitosan-polyethylene glycol modified porous gel layer with a solid content of 89% and a porosity of 8%.

[0044] The lo...

Embodiment 2

[0052] Such as figure 1 As shown, the integrated composite multi-layer anti-adhesion hemostatic sponge includes an upper surface woven protective layer 1 with a thickness of 3 mm, a middle porous hemostatic gel layer 2 with a thickness of 5 mm, and a lower porous hemostatic gel layer with a thickness of 2.5 mm. The woven fabric composite layer 3; the upper surface woven fabric protective layer 1, the middle porous hemostatic gel layer 2 and the lower surface porous hemostatic gel woven fabric composite layer 3 are laminated sequentially from top to bottom, and pass through between adjacent two layers. An integrated composite multilayer structure formed by cross-linking of hemostatic gel.

[0053] The upper surface woven protective layer 1 is a mesh fabric with a density of 90% woven from chitosan fibers and / or Bletilla striata polysaccharide fibers.

[0054] The middle porous hemostatic gel layer 2 is a chitosan-polyethylene glycol modified porous gel layer with a solid conte...

Embodiment 3

[0063] Such as figure 1 As shown, the integrated composite multi-layer anti-adhesion hemostatic sponge includes an upper surface woven protective layer 1 with a thickness of 2 mm, a middle porous hemostatic gel layer 2 with a thickness of 4 mm, and a porous hemostatic gel layer with a thickness of 1.5 mm on the lower surface. The woven fabric composite layer 3; the upper surface woven fabric protective layer 1, the middle porous hemostatic gel layer 2 and the lower surface porous hemostatic gel woven fabric composite layer 3 are laminated sequentially from top to bottom, and pass through between adjacent two layers. An integrated composite multilayer structure formed by cross-linking of hemostatic gel.

[0064] The upper surface woven protective layer 1 is a mesh fabric with a density of 90% woven from chitosan fibers and / or Bletilla striata polysaccharide fibers.

[0065] The middle porous hemostatic gel layer 2 is a chitosan-polyethylene glycol modified porous gel layer wit...

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Abstract

The invention discloses an integrated composite multilayer anti-adhesion hemostatic sponge. The sponge specifically comprises an upper surface weaving protective layer, a middle porous hemostatic gellayer and a lower surface porous hemostatic gel weaving composite layer which are sequentially bonded and crosslinked to form an integrated composite multi-layer structure. The upper surface weaving protective layer comprises a middle porous hemostatic gel layer and a lower surface porous hemostatic gel composite layer, wherein the upper surface weaving protective layer is a mesh fabric woven by chitosan fiber and / or bletilla striata polysaccharide fiber. The intermediate porous hemostatic gel layer is chitosan. Polyethylene glycol modified porous gel layer. A low surface porous hemostatic gelwoven composite lay is composed of bletilla striata polysaccharide modified fiber woven cloth and chitosan, wherein that lower surface porou hemostatic gel woven composite layer is composed of bletilla striata polysaccharide modified fiber and chitosan. Polyethylene glycol modified porous gel composite. The whole sponge product has the advantages of high molding degree, quick blood suction and hemostasis, good air permeability, persistent hemostasis and bactericidal resistance to infection, good anti-adhesive effect without additional additives, high biocompatibility, and effectively avoidingthe negative influence of the use and release of other additives in the sponge product on the secondary infection of the wound and the like.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an anti-adhesion and hemostatic sponge with multiple layers that has good blood-sucking and hemostasis functions, disinfection and anti-inflammation, good skin adhesion, high use comfort and good adhesion resistance . Background technique [0002] Hemostasis is the most basic method in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. Anesthesia refers to a state that allows patients to undergo surgery or invasive procedures without pain and discomfort. Generally speaking, anesthesia is a kind of reversible functional inhibition of the central nervous system and / or peripheral nervous system produced by drugs or other methods, which is mainly characterized by loss of sensation, especially pain sensation. Usually, arterial or intravenous injection, puncture catheter placement, extubat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00A61L24/00A61L24/04A61L24/08
CPCA61L24/0031A61L24/0036A61L24/046A61L24/08A61F13/00A61F13/00063A61F2013/00906A61F2013/0091A61F2013/00463A61F2013/00676A61F2013/00187A61L2300/418A61L2300/232A61L2400/04A61F13/05C08L5/08C08L5/00C08L71/02
Inventor 舒春柳洪艳
Owner SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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