Multifunctional temperature-sensitive chitosan hydrogel, and preparation method and application thereof
A water-sensitive and multi-functional technology of chitosan, applied in the field of multi-functional temperature-sensitive chitosan hydrogel and its preparation, can solve problems such as complex process, reduce damage, increase accumulation of photothermal substances, and improve utilization rate Effect
Inactive Publication Date: 2019-01-25
UNIV OF SHANGHAI FOR SCI & TECH
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[0005] However, the process of preparing traditional hydrogels is complicated, including the use of harsh conditions such as pH adjustment, oxidizing agents, organic solvents, cross-linking catalysts, or ultraviolet light.
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[0047] The honeysuckle refined product of the present invention and its preparation method and application will be described in more detail below in conjunction with the schematic diagram, wherein a preferred embodiment of the present invention is shown, it should be understood that those skilled in the art can modify the present invention described here, and still realize Advantageous effects of the present invention. Therefore, the following description should be understood as the broad knowledge of those skilled in the art, but not as a limitation of the present invention.
[0048] In the interest of clarity, not all features of an actual implementation are described. In the following description, well-known functions and constructions are not described in detail since they would obscure the invention with unnecessary detail. It should be appreciated that in the development of any actual embodiment, numerous implementation details must be worked out to achieve the develope...
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Abstract
The invention discloses a multifunctional temperature-sensitive chitosan hydrogel, and a preparation method and application thereof. The preparation method comprises the following steps: A, dissolvingCS powder and chemotherapeutic drugs in a solvent, and uniformly stirring to obtain CS mixed solution; B, dissolving the beta-GP powder and the photothermal conversion material in water and evenly stirred to obtain beta-GP mixed solution; and C, dripping the beta-GP mixed solution into CS mixed solution drop by drop, stirring while dripping, and then the obtained mixed liquid is heated to 37 DEGC to obtain composite hydrogel. As a carrier for supporting anti-tumor drug or photothermal conversion materials, in the present application, the thermosensitive CS and the photothermal conversion material are utilized to automatically gel the mixed liquid after heating, thereby realizing targeted drug delivery and increasing the accumulation of photothermal substances at a tumor site. Hydrogels have the efficacy of photothermic photothermic materials and chemotherapy chemotherapy of chemotherapeutic drugs to treat tumor. Photothermal materials and chemotherapeutic drugs are trapped in the hydrogel material and do not enter the blood circulation in large quantities.
Description
technical field [0001] The invention relates to the field of biological nanomaterials, in particular to a multifunctional temperature-sensitive chitosan hydrogel and its preparation method and application. Background technique [0002] As an effective alternative to traditional tumor treatment methods, photothermal therapy of tumors has received extensive attention this year. Photothermal therapy for tumors has the characteristics of low cost, strong targeting (especially for some organs that are difficult to perform surgery), and few side effects. By gathering a material with high photothermal conversion efficiency near the tumor, the infrared laser can be converted into a large amount of heat under the irradiation of a certain wavelength of laser light to kill cancer cells. However, photothermal materials are not easy to accumulate in the tumor site for a long time or to be cleared quickly, and the heat generated is not enough to completely destroy cancer cells, so the tr...
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Login to View More IPC IPC(8): A61K41/00A61K9/06A61K31/4745A61K31/704A61K47/36A61K47/24A61P35/00A61L24/08A61L24/00
CPCA61K9/0024A61K9/06A61K31/4745A61K31/704A61K41/0052A61K47/24A61K47/36A61L24/0031A61L24/08A61L2400/06A61P35/00A61K2300/00C08L5/08
Inventor 王世革郑雨婷
Owner UNIV OF SHANGHAI FOR SCI & TECH