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Microneedle template and preparation method and application thereof

A technology of microneedle and template, applied in the direction of microneedle, needle, and other medical devices, etc., can solve the problems of difficulty in ensuring the uniform tip of the pinhole, affecting the sharpness of the tip of the pinhole, and difficult to prepare the sharpness of the tip. , to achieve the effect of low performance shrinkage, no physiological side effects, and good uniformity

Inactive Publication Date: 2019-01-29
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, silicon microneedle molds are processed and prepared by microelectronic system processing method and chemical etching method. The former has a complicated operation process, and the latter is difficult to prepare microneedles with sharp tips; PDMS microneedle molds must first be prepared by chemical etching, Photolithography, laser cutting, etc., prepare solid microneedles with silicon or metal materials, and then prepare PDMS reverse molds with formed microneedle molds. This technology requires the cooperation of formed solid microneedle molds before preparation, which affects the pinholes. Sharpness of the tip and low preparation efficiency, complicated process, and high cost; the preparation of microneedle molds from hard materials such as gypsum and purple sand requires the use of hole-forming tools to pierce holes, and it is difficult to ensure the uniformity of the pinhole and the sharpness of the tip And it is not suitable for the preparation of soluble drug-loaded microneedles

Method used

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  • Microneedle template and preparation method and application thereof
  • Microneedle template and preparation method and application thereof
  • Microneedle template and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The microneedle template with a height of 300μm, a bottom diameter of 300μm, a pitch of 1700μm, and a 10×14 array is made as follows:

[0028] 1) Mix the low-molecular-weight bisphenol A epoxy resin adhesive (A) and the amine curing agent adhesive (B) at a mass ratio of 2.5:1, stir until the glue is completely transparent without wire drawing, and cure at 50°C for 90 minutes , Make it enter the maturation stage.

[0029] 2) Place the prepared metal microneedles on the epoxy resin film in the curing stage, press uniformly, and place them at room temperature for 5 hours to obtain a microneedle template with uniform thickness.

[0030] 3) Measure the thickness of the microneedle template obtained, place it in a package at room temperature for storage, and mark the size parameters of the microneedle template. The parameters of the aforementioned microneedle template are 300±10μm in height, 300±10μm in bottom diameter, 1700μm in pitch, and 10×14 microneedles in the array.

Embodiment 2

[0032] The height is 500μm, the bottom diameter is 500μm, the spacing is 1800μm, and the 10×14 array microneedle template is made. Proceed as follows:

[0033] 1) Mix the low molecular weight bisphenol A epoxy resin adhesive (A) with the amine curing agent adhesive (B) at a mass ratio of 3:1, stir until the glue is completely transparent without drawing inside, and cure at 70℃ for 1h , Make it enter the maturation stage.

[0034] 2) Place the prepared metal microneedles on the epoxy resin film in the curing stage, press uniformly, and place them at room temperature for 3 hours to obtain a microneedle template with uniform thickness.

[0035] 3) Measure the thickness of the microneedle template obtained, place it in a package at room temperature for storage, and mark the size parameters of the microneedle template. The parameters of the aforementioned microneedle template are 500±10μm in height, 500±10μm in base diameter, 1800μm in pitch, and 10×14 microneedles in the array.

[0036]...

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Abstract

The invention relates to a microneedle template and a preparation method and application thereof and belongs to the technical field of dosage form equipment. The microneedle template is made from epoxy resin film. Micropore arrays are perpendicularly formed in the surface of the epoxy resin film. Micropores are in the shapes of inverted cones, and the tips of the cones face towards the inner sideof the film. Microneedle bodies are formed in the micropores in the preparation process of microneedles. Compared with the prior art, the microneedle template is good in micropore uniformity, tenacious, durable, and capable of being used for preparation of biologically-soluble microneedles in the medicine and beauty fields, and in addition, the prepared microneedles can be used for transdermal drug delivery or transdermal treatment; the microneedle template is simplex in manufacturing material, simple in technology and convenient to solidify, automatic defoaming can be achieved when the microneedle template is used in cooperation with a curing agent, demoulding is easy, the preparation efficiency is high, and production automation is easy to achieve; and the template is low in performanceshrinkage and stable in chemical property, and the cost is much lower compared with the prior art in the market.

Description

Technical field [0001] The invention relates to a microneedle template and a preparation method and application thereof, belonging to the technical field of dosage form equipment. Background technique [0002] Transdermal administration is a new type of administration method, which can avoid the first pass effect of the liver and the degradation of the drug by the gastrointestinal tract caused by oral administration, and avoid the pain caused by injection administration. Therefore, it has been rapidly developed . However, due to the barrier function of the stratum corneum of the skin, the penetration rate of most transdermal preparations is low, far from reaching the effective therapeutic concentration. In order to solve this problem, people have adopted a variety of physical and chemical methods to promote the transdermal absorption of drugs. Among them, microneedle as a new type of transdermal drug delivery technology has attracted more and more attention. [0003] At present,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/38A61M37/00
CPCA61M37/0015B29C33/3842A61M2037/0061A61M2037/0023A61M2037/0053
Inventor 于海宁王梦可
Owner DALIAN UNIV OF TECH
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