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A kind of cefdinir capsule and preparation method thereof

A technology of dinir capsule and cefdinir, which is applied in the field of medicine, can solve the problems of poor water solubility, easy generation of static electricity, poor fluidity, etc., and achieves the effects of not easy to fill capsules, large difference in filling amount, and improved fluidity.

Active Publication Date: 2021-02-26
SHIJIAZHUANG NO 4 PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cefdinir raw material is light yellow powder, poor water solubility, easy to generate static electricity, poor fluidity
The solubility of cefdinir is extremely poor, and the dissolution rate is the bottleneck test item that limits cefdinir capsules
At present, carboxymethylcellulose calcium is often used as a disintegrant in the process of preparing solid pharmaceutical preparations, but carboxymethylcellulose calcium relies on imports, and there is no legal source and quality standard in China, which has certain risks
In addition, in China, sodium lauryl sulfate is often used as a solubilizer, but its solubilizing effect is not good

Method used

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  • A kind of cefdinir capsule and preparation method thereof
  • A kind of cefdinir capsule and preparation method thereof
  • A kind of cefdinir capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] prescription:

[0026]

[0027] Preparation Process:

[0028] (1) Cefdinir raw material is pulverized for subsequent use;

[0029] (2) Dissolving poloxamer 188 in 50% ethanol solution to make 10% poloxamer 188 solution for later use;

[0030] (3) Mix cefdinir, low-substituted hydroxypropyl cellulose and magnesium stearate evenly, add the above-mentioned poloxamer 188 solution, wet granulate, dry, and granulate;

[0031] (4) Fill capsules.

Embodiment 2

[0033] prescription:

[0034]

[0035] Preparation Process:

[0036] (1) Cefdinir raw material is pulverized for subsequent use;

[0037] (2) Dissolving poloxamer 188 in 95% ethanol solution to make 10% poloxamer 188 solution for later use;

[0038] (3) Mix cefdinir, low-substituted hydroxypropyl cellulose and magnesium stearate evenly, add the above-mentioned poloxamer 188 solution, wet granulate, dry, and granulate;

[0039] (4) Fill capsules.

Embodiment 3

[0041] prescription:

[0042]

[0043] Preparation Process:

[0044] (1) Cefdinir raw material is pulverized for subsequent use;

[0045] (2) Mix cefdinir, low-substituted hydroxypropyl cellulose, poloxamer 188 and magnesium stearate evenly, add 50% ethanol solution, wet granulate, dry, and granulate;

[0046] (3) Fill capsules.

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Abstract

The invention provides a cefdinir capsule and a preparation method thereof. The contents of the capsule are prepared from the following raw and auxiliary materials in parts by weight: 90-120 parts of cefdinir, 10-40 parts of low-substituted hydroxypropyl cellulose 1-6 parts of poloxamer 188, 1-7 parts of magnesium stearate. The present invention not only can make cefdinir capsule intermediate material It has good fluidity, low static electricity, reduces material sticking to the wall, is easy to fill capsules, and can increase the dissolution of cefdinir capsules to achieve the same dissolution curve as the reference preparation.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a cefdinir capsule and a preparation method thereof. Background technique [0002] Cefdinir is developed by Fujisawa Pharmaceutical Co., Ltd., Japan, and belongs to the third generation of cephalosporins. Cefdinir improves the poor effect of cefixime and other third-generation cephalosporins on Gram-positive bacteria. C 7 Position is the side chain of demethylaminothioxime, C 3 The position is vinyl, which maintains a high stability to β-lactamase, improves the effect on Gram-positive bacteria, and makes cefdinir have a broad-spectrum antibacterial activity. Simultaneously, the pharmacokinetic properties are also improved, so that cefdinir has better oral absorption. Currently, the formulations of cefdinir on the market include dispersible tablets, capsules, and granules. [0003] Cefdinir crude drug is light yellow powder, poor water solubility, easy to generate static el...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/546A61K47/10A61K47/12A61K47/38A61P31/04
CPCA61K9/1617A61K9/1641A61K9/1652A61K31/546A61P31/04
Inventor 殷殿书刘芳菊闫永娜李彪曹柳赵晓雷杨帆
Owner SHIJIAZHUANG NO 4 PHARMA
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