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New method for preparing hydrophilic polyurethane silver ion dressing

A hydrophilic polyurethane, silver ion technology, applied in medical science, bandages, etc., can solve the problems of poor slow release effect of antibacterial ingredients, complicated production of polyurethane silver ion dressings, low processing efficiency, etc. Effectiveness, facilitates sufficient exposure to bacteria, and prevents wound infection

Active Publication Date: 2019-02-01
GUANGDONG TIDAKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention proposes a new method for preparing hydrophilic polyurethane silver ion dressing, which solves the problems of complex production of polyurethane silver ion dressing, low processing efficiency and poor slow-release effect of antibacterial components, etc.

Method used

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  • New method for preparing hydrophilic polyurethane silver ion dressing
  • New method for preparing hydrophilic polyurethane silver ion dressing
  • New method for preparing hydrophilic polyurethane silver ion dressing

Examples

Experimental program
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Embodiment 1

[0028] like figure 1 Shown, a kind of new method that the present invention proposes to prepare hydrophilic polyurethane silver ion dressing comprises the following steps,

[0029] S1, preparation of silver ion aqueous solution: mix and stir in 0.0145g silver sulfate, 100g water;

[0030] S2, preparation of silver ion encapsulating agent aqueous solution: 0.1002g tannic acid is dissolved in 66.66g deionized water, then mix and stir with 20.04g concentration be the polyvinyl alcohol solution of 3.0%;

[0031] S3. Ultrasonic impregnation and drying: impregnate the polyurethane foam in the aqueous solution of silver ion coating agent for 30 minutes, take it out and freeze-dry it at -50°C for 24 hours in the dark, and then perform a second ultrasonic impregnation of the polyurethane foam in the aqueous solution of silver ions. 150W, ultrasonic impregnation time is 30min, take out after impregnation and freeze-dry at -50℃ for 24h in the dark;

[0032] S4, high-energy ray radiation ...

Embodiment 2

[0035] S1, preparation of silver ion aqueous solution: mix and stir in 0.0868g silver sulfate, 100g water;

[0036] S2, preparation of silver ion encapsulating agent aqueous solution: 0.1002g of tannic acid is dissolved in 66.66g of deionized water, and then mixed with 33.34g of polyvinyl alcohol solution with a concentration of 3.0% and stirred evenly;

[0037] S3. Ultrasonic impregnation Ultrasonic impregnation and drying: impregnate the polyurethane foam in the aqueous solution of silver ion coating agent for 30 minutes, take it out and freeze-dry it at -50°C for 24 hours in the dark, and then perform a second ultrasonic impregnation of the polyurethane foam in the aqueous solution of silver ions, wherein The ultrasonic power is 150W, and the ultrasonic impregnation time is 30min. After impregnation, take it out and freeze-dry it at -50°C for 24h in the dark;

[0038] S4, high-energy ray radiation sterilization: the dry polyurethane foam dressing prepared in step S3 with 6...

Embodiment 3

[0041] S1, preparation of silver ion aqueous solution: mix and stir in 0.145g silver sulfate, 100g water;

[0042] S2, preparation of silver ion encapsulating agent aqueous solution: 0.1002g of tannic acid is dissolved in 66.66g of deionized water, then mixes and stirs evenly with 40.08g concentration of polyvinyl alcohol solution of 3.0%;

[0043] S3. Ultrasonic impregnation: Immerse the polyurethane foam in the aqueous solution of silver ion coating agent for 30 minutes, take it out and freeze-dry it at -50°C for 24 hours in the dark, and then ultrasonically impregnate the polyurethane foam in the aqueous solution of silver ions. The ultrasonic power is 150W. The immersion time is 30min. After immersion, take it out and freeze-dry it at -50℃ for 24h in the dark;

[0044] S4, high-energy ray radiation sterilization: the dry polyurethane foam dressing prepared in step S3 with 60 Co is the γ-ray radiation source, and the radiation dose is 30kGy for radiation sterilization.

...

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Abstract

The invention belongs to the technical field of medical materials, and relates to a new method for preparing a hydrophilic polyurethane silver ion dressing. The method comprises: preparing a silver ion aqueous solution with a silver ion concentration of 0.1-1.0 mg / mL by respectively using silver sulfate and deionized water as raw materials; preparing a silver ion encapsulation agent aqueous solution by using polyvinyl alcohol, tannic acid and deionized water as raw materials, wherein a mass ratio of polyvinyl alcohol to tannic acid is 6:1-12:1; and immersing polyurethane foam in the silver ionencapsulation agent aqueous solution for 30 min, taking out, carrying out freeze-drying, carrying out secondary ultrasonic immersing on the polyurethane foam in the silver ion aqueous solution, drying, and carrying out high energy radiation sterilization on the dried polyurethane foam. With the new method of the present invention, the problems of complex production process, low processing efficiency, poor antibacterial component slow-release effect and the like of the existing polyurethane silver ion dressing are solved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and relates to a new method for preparing a hydrophilic polyurethane silver ion dressing. Background technique [0002] The slow-release silver ion gel material is generally composed of silver source and carrier dressing. The commonly used silver source is nano-silver and silver salt, namely Ag 0 and Ag Ⅰ , the carrier dressing is usually a polymer material with good biocompatibility and good hygroscopicity. There are three main methods of adding silver to dressings: mixing method, chemical method and physical method. The difference between these three methods lies in whether the carrier dressing has been formed before adding silver particles. The mixing method is to add the silver source to the dressing raw material liquid before the carrier dressing is formed, and mix evenly so that the silver particles can be evenly distributed in the dressing. The chemical method is to contact th...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0019A61L26/0066A61L26/008A61L2300/104A61L2300/404C08L75/04C08L29/04
Inventor 刘静亮
Owner GUANGDONG TIDAKANG MEDICAL TECH CO LTD
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