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A Type I/Type III Collagen Composite Scaffold Loaded with Mildew Spatholobus

A composite scaffold and the technology of Millipede spathifolia, applied in the field of biomedicine, can solve the problems of inability to fully restore the healthy shape and physiological functions of damaged cartilage tissue, secondary lesions at the donor site, and limited donor sources.

Active Publication Date: 2021-04-27
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, surgical treatment cannot fully restore the original healthy shape and physiological function of damaged cartilage tissue, and there are shortcomings such as limited donor sources, secondary lesions at the donor site, and immune rejection.

Method used

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  • A Type I/Type III Collagen Composite Scaffold Loaded with Mildew Spatholobus
  • A Type I/Type III Collagen Composite Scaffold Loaded with Mildew Spatholobus
  • A Type I/Type III Collagen Composite Scaffold Loaded with Mildew Spatholobus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) ① Accurately weigh 0.06 g PLGA (molecular weight: 50,000, ratio: 75:25), dissolve in 1.2 mL of dichloromethane, and store in a refrigerator at 4°C for later use; ② Accurately weigh 0.5 mg of Spatholobus Spatholobus Place in 10 mL of ultrapure water, and dissolve it completely at 37°C; ③accurately weigh 0.09 g of PVA, place it in 9 mL of ultrapure water, and dissolve it completely in a water bath at 60°C; Take 600 uL of the Caulis Spatholobus solution described in step ② and slowly inject it into the PLGA solution described in step ①; will step The mixed liquid was emulsified in an ice-water bath for 2 minutes with a cell disruptor with a probe amplitude of 35% and a 3 mm conical probe (power of 200 W) to form colostrum; will step The colostrum formed in the step is immediately poured into the PVA solution, then use the steps Emulsify in an ice-water bath for 2 min in the cell disruptor to form a double emulsion; will step The double emulsion is fully ...

Embodiment 2

[0038] Change 0.8% beef tendon in step 4) Type collagen solution, 0.8% recombinant human source The mass ratio of type collagen solution was 1:2, and other steps were the same as in Example 1 to prepare composite material B. Its porosity and swelling rate can be as high as 83.9% and 40.1%, respectively.

Embodiment 3

[0040] Change 0.8% beef tendon in step 4) Type collagen solution, 0.8% recombinant human source The mass ratio of type collagen solution was 1:3, and other steps were the same as in Example 1 to prepare composite material C. Its porosity and swelling rate can be as high as 84.1 % and 40.2 %, respectively.

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Abstract

The invention discloses a type I / type III collagen composite scaffold loaded with spaghetti spaghetti. The scaffold is made of bovine-derived collagen, recombinant human-derived collagen, Caulis Spatholobus and PLGA. The preparation process includes the preparation of PLGA microspheres loaded with Caulis Spatholobus, the preparation of type I / III collagen composite scaffold and Steps such as loading of Mildew PLGA microspheres are included. The composite scaffold prepared by the present invention combines the characteristics of type I collagen ribbon fiber structure and type III collagen network fiber structure, and the prepared composite scaffold has a suitable three-dimensional network structure, good biocompatibility, non-toxicity, degradability and The characteristics of low immunogenicity, combined with the therapeutic effect of Spatholobus Spatholobus on osteoarthritis, is a better medical material suitable for the repair and treatment of cartilage defects in osteoarthritis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a type I / type III collagen composite scaffold loaded with spaghetti spaghetti and a preparation method thereof. Background technique [0002] In recent years, the incidence of joint diseases in my country has been increasing. Articular cartilage is a very complex hyaline-like cartilage connective tissue with a smooth and shiny surface, which mainly plays the role of weight-bearing and movement in joint activities. When the cartilage is damaged, its nutrient absorption is limited and the tissue lacks blood supply, which will lead to the gradual deterioration of the condition of the injured part, and eventually develop into knee osteoarthritis (Knee osteoarthritis, KOA). Sexual pain, swelling, mobility impairment, severe knee joint deformity and even disability seriously affect the life and health of patients. Although there are many causes of KOA, the defects and degenerat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61L27/56A61L27/58A61L27/50A61L27/54A61L27/36
CPCA61L27/24A61L27/36A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/30A61L2300/41A61L2300/602A61L2300/622
Inventor 王建华王营营黄晨光孙晓敏张其清
Owner FUZHOU UNIV
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