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Modified rice bran alcohol and its preparation method and application

A rice bran and modified technology, which is applied in the directions of pharmaceutical formulations, organic active ingredients, medical preparations of non-active ingredients, etc., can solve the problems of easy agglomeration and inconvenience in use.

Active Publication Date: 2021-05-28
SINO NUTRACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the injection is used, it needs to be injected deep into the muscle, which is inconvenient to use. At the same time, the intramuscular injection is easy to agglomerate, which brings great pain to the patient.

Method used

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  • Modified rice bran alcohol and its preparation method and application
  • Modified rice bran alcohol and its preparation method and application
  • Modified rice bran alcohol and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weight percent:

[0027]

[0028]

[0029] Preparation:

[0030] (1) rice bran alcohol, hydroxypropyl methylcellulose and copovidone are mixed;

[0031] (2) The hydrogenated castor oil that melts is added in the mixture of step 1 by wet granulation;

[0032] (3) Add silicon dioxide to the mixture in step 2 through a 40-mesh sieve;

[0033] (4) Put the mixture of step (3) into an extruder, melt and extrude at 120° C., and pulverize after cooling to obtain the modified rice bran alcohol;

[0034] Visual inspection: Appearance of cooled solid dispersion: transparent, bright and no obvious lumps;

[0035] Dissolution test: Take 5g and dissolve it in 100ml of water. After shaking gently, it will become a uniform cloudy liquid, while the copovidone solution is colorless;

[0036] Glass transition temperature (Tg) detection: through TA Q2000 differential scanning calorimeter (mDSC) analysis and detection, the glass transition temperature of VA64 is 98.73 ° C, and the...

Embodiment 2

[0038]

[0039] Preparation:

[0040] (1) rice bran alcohol, hydroxypropyl methylcellulose and copovidone are mixed;

[0041] (2) The hydrogenated castor oil that melts is added in the mixture of step 1 by wet granulation;

[0042] (3) Add silicon dioxide to the mixture in step 2 through a 40-mesh sieve;

[0043] (4) Put the mixture of step (3) into an extruder, melt and extrude at 110° C., and pulverize after cooling to obtain the modified rice bran alcohol;

[0044] Visual inspection: Appearance of cooled solid dispersion: transparent, bright and no obvious lumps;

[0045] Dissolution test: Take 5g and dissolve it in 100ml of water. After shaking gently, it will become a uniform cloudy liquid, while the copovidone solution is colorless;

Embodiment 1、 Embodiment 2

[0047] Solubility determination of rice furfuryl alcohol in embodiment 1, embodiment 2 solid dispersion

[0048] Sample preparation: take the physical mixture of excessive solid dispersion powder and carrier material of embodiment 1 and embodiment 2 respectively (weigh rice bran alcohol and carrier adjuvant according to the prescription amount, and obtain after simple mixing) and put it into an appropriate container, respectively After adding the pH6.8 phosphate buffer which is equivalent to 2 / 3 of the container price increase, shake it in a shaker at 37°C for 10 minutes, filter the resulting solution with a 0.45μm filter membrane, collect the filtrate, and rinse with an appropriate amount of water After further dilution and vortex mixing, the sample was injected and analyzed by gas chromatography. The results are shown in Table 1

[0049] Chromatographic column: glass chromatographic column (2.1m*3mm)

[0050] Carrier: chromosrob W (Aw) 60-80 mesh

[0051] Stationary phase...

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Abstract

The invention discloses a modified rice bran alcohol and its preparation method and application. The modified rice bran alcohol is a mixture containing rice bran alcohol, copovidone, hydroxypropyl methylcellulose and hydrogenated castor oil. In the present invention, the bioavailability of rice bran alcohol is improved by making a solid dispersion, and the insoluble rice bran alcohol is made into a solid dispersion. In the solid dispersion, the insoluble drug molecules are distributed in the high molecular weight carrier material in an amorphous form. , high bioavailability.

Description

technical field [0001] The present invention relates to a composition containing rice bran alcohol. Background technique [0002] Rice bran alcohol is a 28-carbon fatty alkanol, which is a safe and effective functional factor. Its LD50 is more than 18000mg / kg, and its safety is higher than that of table salt (LD50=3000mg / kg). At the same time, it was negative in the mouse sperm aberration test, mouse bone marrow micronucleus test and Ames test. Cuban Natural Products Center C.L.Aleman The arguments of other scholars also confirmed this point. It has the functions of: improving endurance and energy; improving responsiveness; improving stress ability; reducing muscle pain; improving myocardial function; Effect, this improvement has no dependence, and the mechanism of melatonin is different. [0003] The rice bran alcohol is poorly soluble in water, and its oral availability is very low, which leads to the need for a large amount of drugs when actually taken by patients, whi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/341A61K47/44A61K47/38A61K47/32A61K47/02A61P25/20
CPCA61K31/341A61K47/02A61K47/32A61K47/38A61K47/44A61P25/20
Inventor 顾茂健苏健梅
Owner SINO NUTRACEUTICAL CO LTD