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Gel plaster for treating dysmenorrhea and preparation method of gel plaster

A technology for gel and dysmenorrhea, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of insufficient extraction of active ingredients, large randomness, etc., and achieve peeling strength. High, good initial viscosity, easy to use

Inactive Publication Date: 2019-02-15
谈宗华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above Shaofu Zhuyu Decoction and Wenjing Decoction are generally decocted in water, and the resulting decoction contains water-soluble components. Due to the randomness of the decoction process, volatile oils, organic acids, alkaloids, flavonoids and other medicinal components often Insufficient extraction

Method used

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  • Gel plaster for treating dysmenorrhea and preparation method of gel plaster
  • Gel plaster for treating dysmenorrhea and preparation method of gel plaster
  • Gel plaster for treating dysmenorrhea and preparation method of gel plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Extract, its concrete preparation steps are:

[0043] A. Add 57.69g angelica, 38.46g Chuanxiong, 19.23g Guangui, 0.385g fennel, 38.46g myrrh and 3.846g dried ginger to 10 times the total mass of water, soak for 30min, and extract by steam distillation for 6h to obtain volatile oil , medicinal residues and extract A;

[0044] B. 38.46g Radix Paeoniae Rubra, 19.23g Yuanhu, 57.69g Puhuang, 38.64g Wulingzhi and the medicinal residue obtained in step A are added to 70% ethanol solution with a volume fraction of 9 times of its total mass, and extract 2 times, each After 1.5 hours, recover the ethanol in the extract until there is no alcohol smell, and obtain extract B, combine and concentrate extract B and extract A to a relative density of 1.08-1.09 at 50°C to obtain primary extract, and then add volatile oil Mix well and serve.

[0045] Active ingredient testing

[0046] (1) Preparation of reference substance solution

[0047] Accurately weigh the appropriate amount of ...

Embodiment 2

[0070] The gel patch for treating dysmenorrhea is prepared by using the following raw materials and processes:

[0071] A. Add 15g of purified water to 2.6g of Carbomer 940, and let it stand overnight to fully swell, as phase A;

[0072] B. Disperse 2.42g sodium polyacrylate 700, 0.96g kaolin and 0.25g aluminum glyoxate evenly with 16g glycerin as phase B, and dissolve 0.16g tartaric acid with 1g water as phase C;

[0073] C. Add phase A to phase B, stir evenly, add phase C and 8g of the extract prepared in Example 1, stir evenly in a water bath (60°C), then immediately spread it on the non-woven fabric, and put it in an oven at 30°C Place it for 12h, and you get it.

Embodiment 3

[0075] Performance Testing

[0076] The gel plaster prepared in Example 2 was tested for appearance properties, initial adhesion, holding power and peel strength. At the same time, comprehensive evaluation according to the formula = appearance property score × 0.4 + initial adhesion score × 0.2 + holding power Score * 0.2+peel strength * 0.2 measures the comprehensive evaluation of the gel plaster that embodiment 2 makes, and the results are as shown in table 2;

[0077] Wherein, the appearance properties are evaluated according to the standards shown in Table 1;

[0078] The detection method of initial adhesion is: take the gel paste, remove the anti-adhesive layer, fix it on the initial adhesion tester, and adjust the inclination angle to 30°. Roll a steel ball of a certain weight specification (No. 10) from the top of the slope freely, measure the rolling distance of the steel ball when it is stuck by the paste, record the reading, repeat the measurement 3 times, and take ...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations containing radix angelicae sinensis and particularly relates to gel plaster for treating dysmenorrhea. The gel plaster is prepared from the following components: carbomer, sodium polyacrylate, dihydroxyaluminium aminoacetate, kaolin, glycerol, tartaric acid and an extract; a preparation method of the extract comprises thefollowing steps: adding radix angelicae sinensis, rhizoma chuanxiong, cortex cinnamomi, fructus foeniculi, myrrh and rhizoma zingiberis into water, soaking and carrying out steam distillation and extraction to obtain volatile oil, herb residues and an extracting solution A; adding radix paeoniae rubra, rhizoma corydalis, pollen typhae, trogopterus dung, cortex cinnamomi and the herb residues intoan ethanol solution for extracting, recovering the ethanol in the extracting solution until no alcohol taste is produced to obtain an extracting solution B; combining and concentrating the extractingsolution A and the extracting solution B to obtain an initial extract; then adding the volatile oil and uniformly mixing, thus obtaining a finished product.

Description

technical field [0001] The invention belongs to the technical field of medicinal preparations containing angelica, and in particular relates to a gel plaster for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to the occurrence of abdominal pain, backache, lower abdominal swelling, etc. during the menstrual cycle. Some patients may experience nausea, vomiting, or even syncope when the pain is severe. In severe cases, it may even affect work and life. Pain, pale tongue, thready pulse, first belonged to the category of "abdominal pain during menstruation" ("Observation on the Curative Effect of Integrative Traditional Chinese and Western Medicine on Primary Dysmenorrhea", Yang Haiping, Modern Medicine and Health, Volume 31, Issue 17, 2015, No. 2653 -2655 pages, published on September 30, 2015). Dysmenorrhea can be divided into two categories: primary dysmenorrhea and secondary dysmenorrhea. Primary dysmenorrhea refers ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/70A61P15/00A61K35/24
CPCA61K9/7023A61K35/24A61K36/232A61K36/235A61K36/236A61K36/328A61K36/54A61K36/65A61K36/66A61K36/71A61K36/88A61K36/9068A61K47/32A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P15/00A61K2300/00
Inventor 谈宗华
Owner 谈宗华
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