Nano-particle for improving tumor tissue penetrability, preparation method of nano-particle and application of nano-particle

A nanoparticle, tumor tissue technology, applied in biochemical equipment and methods, nanotechnology, nanotechnology, etc., can solve problems such as accelerating tumor deterioration and difficulty
CN109364253AInactive Publication Date: 2019-02-22NANKAI UNIV
3 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANKAI UNIV
Publication Date
2019-02-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of medicines for treating tumors, and provides a nano-particle for improving tumor tissue penetrability. The nano-particle comprises hollow mesoporous Prussian blue nano-particles, phase-change materials, tumor matrix degradation materials and anti-tumor medicines, the phase-change materials are loaded in the hollow portions of the hollow mesoporous Prussian blue nano-particles, the tumor matrix degradation materials and the anti-tumor medicines are embedded into the phase-change materials, and the phase-change materials comprise lauric acid, 9-heptadecanone and decanoic acid or 1-tetradecyl alcohol. According to the nano-particle for improving the tumor tissue penetrability, the anti-tumor medicines can enter tumor tissues, and the anti-tumor rate of the nano-particle can reach 81.3%.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of medicine for treating tumors, in particular to a nanoparticle for improving the permeability of tumor tissue, its preparation method and application. Background technique

[0002] Cancer is the primary chronic disease that threatens human health, and chemotherapy is the basic method for clinical treatment of tumors. Due to the advantages of long blood circulation, selective tumor enrichment, long residence time in tumor sites, and low toxicity, nanomedicine is expected to overcome the shortcomings of small molecule chemotherapy drugs and improve its antitumor effect. However, the average amount of nanoparticles reaching the tumor site is only 0.7% of the injected dose, and most of the nanoparticles can only stay around the blood vessels and cannot enter the center of the tumor, which greatly limits the therapeutic effect of nanomedicine. For example, Professor Liang Xingjie studied the penetration perfor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More