Toothpaste containing polygonum cuspidatum and preparation method of toothpaste

A technology for toothpaste and knotweed, which is applied in the field of daily chemical products, can solve the problems of high polarity of solvents, reduced activity, and reduced bacteriostatic effect of antibacterial components, and achieves the conditions of mild preparation method, maintenance of bacteriostatic activity, and good bactericidal effect Effect

Inactive Publication Date: 2019-02-26
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN106619156 has the following deficiencies: (1) the used anhydrous calcium hydrogen phosphate, hydroxyapatite, sodium lauroyl sarcosinate, sodium alginate, and polyphosphate are all alkaline auxiliary materials, resulting in the final Toothpaste is alkaline, which will reduce the antibacterial effect of antibacterial ingredients; (2) the pH of human saliva is 6.6-7.1, alkaline toothpaste will destroy the pH environment of the oral cavity, change the structure of oral flora and reduce the bactericidal lysozyme activity; (

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The components and weight percentages of the toothpaste containing Polygonum cuspidatum are: 0.5% of Polygonum cuspidatum extract, 18% of frictional silica, 3% of thickened silica, 13% of glycerin, 52% of sorbitol liquid, carboxymethyl cellulose Sodium 1%, Sodium Lauryl Sulfate 1.5%, Sodium Saccharin 0.1%, Sodium Benzoate 0.2%, Menthol 0.3%, Citric Acid 0.2%, Deionized Water 10.2%. The weight of Polygonum cuspidatum extract is calculated as the medicinal material.

[0042] Preparation:

[0043] (1) get 0.5 parts by weight of Polygonum cuspidatum and make powder after drying at 60 DEG C, then use 5 parts by weight of 70wt% ethanol to percolate and extract, the percolation speed is 3ml / kg / min, and the extract is dried to an extract sample, that is, the extract of Polygonum cuspidatum is obtained. thing;

[0044] (2) Add 0.5 parts by weight of deionized water to the Polygonum cuspidatum extract to dissolve, and centrifuge at 1500 r / min for 15 min to obtain a clear aqueous ...

Embodiment 2

[0050] The components and weight percentages of the toothpaste containing Polygonum cuspidatum are: 1% Polygonum cuspidatum extract, 18% frictional silica, 7% thickening silica, 15% glycerin, 46% sorbitol liquid, carboxymethyl cellulose Sodium 2%, Sodium Lauryl Sulfate 3%, Sodium Saccharin 0.3%, Sodium Benzoate 0.4%, Menthol 0.4%, Citric Acid 0.3%, Deionized Water 6.6%. The weight of Polygonum cuspidatum extract is calculated as the medicinal material.

[0051] Preparation:

[0052] (1) take 1 part by weight of Polygonum cuspidatum and make powder after drying at 55 DEG C, then extract with 12 parts by weight of 70wt% ethanol, reflux at 80 DEG C for 45min, and dry the extract to an extract sample to obtain the Polygonum cuspidatum extract;

[0053] (2) Polygonum cuspidatum extract is dissolved in 3 parts by weight of deionized water, and filtered to obtain a clear aqueous solution of Polygonum cuspidatum extract;

[0054] (3) add 0.4 parts by weight of sodium benzoate, 0.3 p...

Embodiment 3

[0059] The components and weight percentages of the toothpaste containing Polygonum cuspidatum are: 4% of Polygonum cuspidatum extract, 25% of frictional silica, 6% of thickened silica, 10% of glycerin, 40% of sorbitol liquid, carboxymethyl cellulose Sodium 2.5%, Sodium Lauryl Sulfate 2.2%, Sodium Saccharin 0.5%, Sodium Benzoate 0.2%, Menthol 0.5%, Citric Acid 0.3%, Arginine 0.1%, Deionized Water 8.7%. The weight of Polygonum cuspidatum extract is calculated as the medicinal material.

[0060] Preparation:

[0061] (1) get 4 parts by weight of Polygonum cuspidatum and make powder after drying at 50 DEG C, then use 60 parts by weight of 80wt% ethanol to ultrasonically extract, ultrasonically 30min, and the extract is dried to an extract sample to obtain Polygonum cuspidatum extract;

[0062] (2) Polygonum cuspidatum extract is dissolved in 6 parts by weight of deionized water, and filtered with multi-layer gauze to obtain a clear aqueous solution of Polygonum cuspidatum extrac...

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Abstract

The invention belongs to the field of daily chemical products, in particular to toothpaste containing polygonum cuspidatum and a preparation method of the toothpaste. The toothpaste containing the polygonum cuspidatum comprises the following ingredients by weight percentage: 0.5-8% of polygonum cuspidatum extract, 15-25% of friction silicon oxide, 3-10% of thickening silicon oxide, 10-18% of glycerol, 40-52% of sorbitol solution, 1-3% of sodium carboxymethylcellulose, 1.5-3% of lauryl sodium sulfate, 0.1-0.5% of saccharin sodium, 0.2-0.4% of sodium benzoate, 0.3-0.5% of menthol, 0.2-0.4% of citric acid and the balance of deionized water. The prepared toothpaste containing the polygonum cuspidatum is uniform and transparent in character, has a pH (potential of hydrogen) close to that of human saliva, and can prevent anthraquinone and tannin active ingredients from being oxidized, keep a better antibacterial and anti-caries effect, whiten teeth, refresh breath and the brain and regain consciousness.

Description

technical field [0001] The invention belongs to the field of daily chemical products, in particular to a toothpaste containing Polygonum cuspidatum and a preparation method thereof. Background technique [0002] Dental caries, commonly known as cavities and tooth decay, is an infectious disease of common oral diseases. Streptococcus mutans and Streptococcus sobrinus are the main pathogenic bacteria. Pathogenic bacteria produce glucose invertases (GTFs) and synthesize water-insoluble glucose from sucrose, which enables bacteria to adhere firmly to the surface of teeth and promotes the formation of dental plaque. Dental caries can be secondary to pulpitis and apical periodontitis, and can even cause inflammation of the alveolar and jaw bones. If caries are not treated in time, the lesions will continue to develop, forming cavities, and eventually the crown will be completely destroyed, eventually leading to tooth loss. [0003] Many anti-cavity and antibacterial toothpastes ...

Claims

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Application Information

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IPC IPC(8): A61K8/25A61K8/365A61K8/44A61K8/9789A61Q11/00
CPCA61K8/25A61K8/365A61K8/44A61K2800/28A61Q11/00A61K8/9789
Inventor 杨艳芳熊羿屹尤朋涛吴和珍陆毅熊唯琛刘博谢周涛姚云峰余国军
Owner HUBEI UNIV OF CHINESE MEDICINE
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