Water soluble fullerene clathrate for chemicals for daily use and preparation method thereof

A fullerene and water-soluble technology, applied in chemical instruments and methods, cosmetic preparations, surface active detergent compositions, etc., can solve problems such as high cost, complicated reaction process, and complicated process conditions, and achieve good results. Effects of antioxidant activity, excellent physiological activity, and good stability

Pending Publication Date: 2019-02-26
苏州大德碳纳米科技有限公司
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the large use of organic solvents, the residual problem of halogenated aliphatic hydrocarbon solvents or the pressure on the environment, these technologies are worrying, and the process conditions adopted are extremely complicated, involv

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example one:

[0031] 100mg fullerene C 60 The powder and 1.5 mg of sodium lauroyl sarcosinate are placed in an agate mortar and mixed uniformly, 10 mL of ethanol is added, and the mixture is wet-ground for 15 minutes and dried in vacuum. Then add the dried powder mixture together with 200 mg of γ-cyclodextrin to a ball mill for ball milling. The temperature of the ball mill is kept at 15-20°C, the rotating speed is 35 Hz, and the milling time is 24 hours. Dissolve the well-mixed brown powder after ball milling in 250 mL of deionized water, sonicate, and fully stir for 2 hours. The stirred aqueous solution was filtered under reduced pressure with a filter membrane with a filter pore of 1 μm. Rotate the obtained aqueous solution to half of its original volume, place it in a freeze dryer to remove water, and obtain water-soluble fullerene / γ-cyclodextrin inclusion compound solid powder after pulverization, weighing about 150mg, yield About 50%, the scavenging capacity of su...

Example Embodiment

[0032] Embodiment two:

[0033] Put 100 mg of fullerene powder and 1.5 mg of sodium lauroyl sarcosinate in an agate mortar and mix well, add 10 mL of ethanol, wet ground for 15 minutes, and vacuum dry. Then add the dried powder mixture together with 1 g of γ-cyclodextrin to a ball mill for ball milling. The temperature of the ball mill is maintained at 15-20°C, the rotation speed is 35 Hz, and the milling time is 24 hours. Dissolve the well-mixed brown powder after ball milling in 250 mL of deionized water, sonicate, and fully stir for 2 hours. The stirred aqueous solution was filtered under reduced pressure with a filter membrane with a filter pore of 1 μm. Rotate the obtained aqueous solution to half of its original volume, place it in a freeze dryer to remove water, and obtain water-soluble fullerene / γ-cyclodextrin inclusion compound solid powder after pulverization, weighing about 880mg, yield About 80%, the scavenging capacity of superoxide anion is measured.

Example Embodiment

[0034] Embodiment three:

[0035] Put 100 mg of fullerene powder and 1.5 mg of sodium lauroyl sarcosinate in an agate mortar and mix well, add 10 mL of ethanol, wet ground for 15 minutes, and vacuum dry. Then add the dried powder mixture together with 3 g of γ-cyclodextrin into a ball mill for ball milling. The temperature of the ball mill is kept at 15-20°C, the rotating speed is 25 Hz, and the milling time is 20 hours. Dissolve the well-mixed brown powder after ball milling in 250 mL of deionized water, sonicate, and fully stir for 1 h. The stirred aqueous solution was filtered under reduced pressure with a filter membrane with a filter pore of 1 μm. Rotate the obtained aqueous solution to half of its original volume, place it in a freeze dryer to remove water, and obtain water-soluble fullerene / γ-cyclodextrin inclusion compound solid powder after pulverization, weighing about 2.9g, yield The rate is about 94%. , To determine the scavenging ability of superoxide anion.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a water soluble fullerene clathrate for chemicals for daily use and a preparation method thereof, and relates to the field of chemicals for daily use. According to the preparation method, fullerene powder and an anionic surfactant are grinded in ethanol and then dried in vacuum, then the mixture is ball-milled with a water soluble inclusion material, the powder is dissolvedin water, then vacuum suction filtration is performed to remove undissolved substances, and finally rotary evaporation and freeze drying are carried out to obtain the water soluble fullerene clathrate solid powder. Through physical wrapping, the water soluble fullerene clathrate is prepared, the molecular structure of fullerene is not changed, the fullerene still has good anti-oxidation activity,excellent physiological activity is guaranteed, and the fullerene also has good stability. The preparation method does not use any organic solvent that is harmful to organisms and environment, is green and safe, and can be industrialized.

Description

technical field [0001] The invention relates to the field of daily chemicals, in particular to a water-soluble fullerene inclusion compound for daily chemicals and a preparation method thereof, and also to increasing fullerene C 60 Water-soluble technical field. Background technique [0002] Since their discovery in 1985, fullerenes have attracted much attention due to their special physical and chemical properties. Among them, the most abundant C 60 、C 70 Two kinds of fullerene molecules and their derivatives, complexes, and clathrates have been found to have excellent physiological activities such as antioxidant activity, antibacterial activity, and anticancer activity. In 1992, Charles N. McEwen of DuPont Company discovered that fullerenes have super-strong properties of eliminating free radicals, and thus first proposed the concept that fullerenes can be used as "free radical sponges". Since then, research on the application of fullerenes to remove free radicals has ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K8/73A61K8/19A61K8/44A61Q19/10C11D10/02
CPCA61Q19/10A61K8/19A61K8/44A61K8/738C11D1/10C11D3/0084C11D3/12C11D3/222A61K2800/56
Inventor 刘娟钟留彪徐云飞王巢垒朱马捷婕孙永青张永春
Owner 苏州大德碳纳米科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap