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Water soluble fullerene clathrate for chemicals for daily use and preparation method thereof

A fullerene and water-soluble technology, applied in chemical instruments and methods, cosmetic preparations, surface active detergent compositions, etc., can solve problems such as high cost, complicated reaction process, and complicated process conditions, and achieve good results. Effects of antioxidant activity, excellent physiological activity, and good stability

Pending Publication Date: 2019-02-26
苏州大德碳纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the large use of organic solvents, the residual problem of halogenated aliphatic hydrocarbon solvents or the pressure on the environment, these technologies are worrying, and the process conditions adopted are extremely complicated, involving the use of a large amount of organic or even harmful reagents to organisms.
Therefore, there are environmental and human hazards
In addition, due to the complex reaction process and high cost, it has not been widely used in the field of daily chemicals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 100mg fullerene C 60 The powder and 1.5 mg of sodium lauroyl sarcosinate were placed in an agate mortar and mixed evenly, 10 mL of ethanol was added, wet ground for 15 min, and dried in vacuum. Then add the dried powder mixture and 200 mg of γ-cyclodextrin into a ball mill for ball milling. The ball milling temperature is kept at 15-20° C., the rotating speed is 35 Hz, and the ball milling time is 24 hours. After ball milling, the brownish-yellow powder that was well mixed and homogeneous was dissolved in 250mL deionized water, ultrasonicated, and fully stirred for 2h. The stirred aqueous solution was suction-filtered under reduced pressure with a filter membrane having a filter hole of 1 μm. The obtained aqueous solution was rotary evaporated to half of its original volume, placed in a freeze dryer to remove water, and pulverized to obtain a water-soluble fullerene / γ-cyclodextrin inclusion compound solid powder, weighing about 150mg, the yield About 50%, the superoxi...

Embodiment 2

[0033] Put 100mg of fullerene powder and 1.5mg of sodium lauroyl sarcosinate in an agate mortar and mix evenly, add 10mL of ethanol, wet grind for 15min, and vacuum dry. Then add the dried powder mixture and 1g of γ-cyclodextrin into a ball mill for ball milling. The ball milling temperature is kept at 15-20° C., the rotating speed is 35 Hz, and the ball milling time is 24 hours. After ball milling, the brownish-yellow powder that was well mixed and homogeneous was dissolved in 250mL deionized water, ultrasonicated, and fully stirred for 2h. The stirred aqueous solution was suction-filtered under reduced pressure with a filter membrane having a filter hole of 1 μm. The obtained aqueous solution was rotary-evaporated to half of its original volume, placed in a freeze dryer to remove water, and pulverized to obtain a water-soluble fullerene / γ-cyclodextrin inclusion compound solid powder, weighing about 880mg, the yield About 80%, the superoxide anion scavenging capacity was det...

Embodiment 3

[0035] Put 100mg of fullerene powder and 1.5mg of sodium lauroyl sarcosinate in an agate mortar and mix evenly, add 10mL of ethanol, wet grind for 15min, and vacuum dry. Then add the dried powder mixture and 3g of γ-cyclodextrin into a ball mill for ball milling. The ball milling temperature is kept at 15-20° C., the rotating speed is 25 Hz, and the ball milling time is 20 hours. After ball milling, the brownish-yellow powder that was well mixed and homogeneous was dissolved in 250mL of deionized water, ultrasonicated, and fully stirred for 1h. The stirred aqueous solution was suction-filtered under reduced pressure with a filter membrane having a filter hole of 1 μm. The obtained aqueous solution was rotary-evaporated to half of its original volume, placed in a freeze dryer to remove water, and pulverized to obtain a water-soluble fullerene / γ-cyclodextrin inclusion compound solid powder, weighing about 2.9g, yielding The rate is about 94%. , to measure the superoxide anion ...

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Abstract

The invention discloses a water soluble fullerene clathrate for chemicals for daily use and a preparation method thereof, and relates to the field of chemicals for daily use. According to the preparation method, fullerene powder and an anionic surfactant are grinded in ethanol and then dried in vacuum, then the mixture is ball-milled with a water soluble inclusion material, the powder is dissolvedin water, then vacuum suction filtration is performed to remove undissolved substances, and finally rotary evaporation and freeze drying are carried out to obtain the water soluble fullerene clathrate solid powder. Through physical wrapping, the water soluble fullerene clathrate is prepared, the molecular structure of fullerene is not changed, the fullerene still has good anti-oxidation activity,excellent physiological activity is guaranteed, and the fullerene also has good stability. The preparation method does not use any organic solvent that is harmful to organisms and environment, is green and safe, and can be industrialized.

Description

technical field [0001] The invention relates to the field of daily chemicals, in particular to a water-soluble fullerene inclusion compound for daily chemicals and a preparation method thereof, and also to increasing fullerene C 60 Water-soluble technical field. Background technique [0002] Since their discovery in 1985, fullerenes have attracted much attention due to their special physical and chemical properties. Among them, the most abundant C 60 、C 70 Two kinds of fullerene molecules and their derivatives, complexes, and clathrates have been found to have excellent physiological activities such as antioxidant activity, antibacterial activity, and anticancer activity. In 1992, Charles N. McEwen of DuPont Company discovered that fullerenes have super-strong properties of eliminating free radicals, and thus first proposed the concept that fullerenes can be used as "free radical sponges". Since then, research on the application of fullerenes to remove free radicals has ...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/19A61K8/44A61Q19/10C11D10/02
CPCA61Q19/10A61K8/19A61K8/44A61K8/738C11D1/10C11D3/0084C11D3/12C11D3/222A61K2800/56
Inventor 刘娟钟留彪徐云飞王巢垒朱马捷婕孙永青张永春
Owner 苏州大德碳纳米科技有限公司
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