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Novel fish oil soft capsule and preparation method thereof

A soft capsule, fish oil technology, applied in the field of medicine, to achieve the effects of reducing irritation, good stability and portability, and improving bioavailability

Inactive Publication Date: 2019-02-26
陆文捷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research is limited to the replacement of ordinary soft capsules with plant-based capsules, and the research on fish oil soft capsules is limited to chewable soft capsules

Method used

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  • Novel fish oil soft capsule and preparation method thereof
  • Novel fish oil soft capsule and preparation method thereof
  • Novel fish oil soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Contents (self-microemulsion) prescription:

[0030]

[0031] Capsule shell prescription:

[0032] Gelatin: Plasticizer: Water = 1:0.5:1

[0033] Preparation Process:

[0034] (1) Prepared from microemulsion:

[0035] A. Add fish oil to the prescribed amount of castor oil to completely dissolve it

[0036] B. Then add the prescription amount of RH40, 1,2-propanediol, propyl gallate, and vitamin E to the above A solution in turn, stir until it is clear and transparent, and prepare a fish oil self-microemulsion preparation

[0037] C. Take an appropriate amount of fish oil self-microemulsion solution prepared by B, dilute with 100 times of water, and emulsify

[0038] D. Take an appropriate amount of C microemulsion and measure the average particle size of its particle size distribution with a particle size potentiometer to 20nm.

[0039] (2) Preparation of soft capsules:

[0040] A. Preparation of contents: Weigh the stabilizer and fish oil in proportion, mix them evenly and reserve;

...

Embodiment 2

[0046] Contents (self-microemulsion) prescription:

[0047]

[0048] Capsule shell prescription:

[0049] Cellulose acetate 8%, triethyl citrate 2% polyethylene glycol 6000 5%, acetone 85%.

[0050] Preparation Process:

[0051] (1) Preparation of self-microemulsion: same as Example 1, the particle size distribution was measured with a particle size potentiometer, and the average particle size was 50 nm.

[0052] (2) Preparation of soft capsules: first dissolve cellulose acetate, then add triethyl citrate and polyethylene glycol into the acetone solution to make the shell material, which is obtained by pressing, shaping, and drying.

Embodiment 3

[0054] Contents (self-microemulsion) prescription:

[0055]

[0056] Capsule shell prescription:

[0057] Bletilla gum 10%, calcium gluconate 2%, mannitol 2%, glycerol 6%, stabilizer 2%, distilled water 78%.

[0058] Preparation Process:

[0059] (1) Preparation of self-microemulsion: same as Example 1, the particle size distribution was measured with a particle size potentiometer, and the average particle size was 100 nm.

[0060] (2) Preparation of soft capsules: first dissolve Bletilla striata gum, then add plasticizers and stabilizers to the above-mentioned solution to make capsule shell materials, which are then obtained by pressing, shaping, and drying.

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Abstract

The invention relates to a novel fish oil soft capsule and a preparation method thereof. The soft capsule is simple in preparation technology and wide in selection range of fish oil species, and can enhance the bioavailability of drugs. The soft capsule consists of a capsule shell and contents; the capsule shell can be made of gelatin and non-gelatin materials; and the contents are formed by self-microemulsion with different particle sizes and prepared by fish oil, and can increase the stability and dissolvability of the drugs and enhance dissolution rate, so that the curative effects of the drugs can be improved. The soft capsule has characteristics of being easy in storage and keeping, simple in preparation technology and high in bioavailability.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of a pharmaceutical preparation, in particular to a fish oil self-microemulsion preparation and a method for preparing self-microemulsion of different particle sizes by adjusting the prescription ratio. Background technique [0002] Fish oil is a general term for all oils in fish. It includes body oil, liver oil and brain oil. The main fish oil is an oil extracted from fatty fish, rich in omega-3 polyunsaturated fatty acids (DHA and EPA) ), has health benefits such as anti-inflammatory and regulating blood lipids. The main functional component of fish oil is the omega-3 series of polyunsaturated fatty acids. The best ratio of omega-6 fatty acids and omega-3 fatty acids is 1:1 or 4:1 at most. This ratio can promote the normal operation of the brain. Now in life, omega-6 fatty acids: 15-20:1 of omega-3 fatty acids will make the brain Malfunction. Fish oil is rich ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/107A61K35/60
CPCA61K9/1075A61K9/4808A61K9/4825A61K35/60
Inventor 陆文捷胡容峰
Owner 陆文捷
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